Prognostic Value of BRCA1 and BRCA2 Gene Mutations in Prostate Cancer: a Literature Review
Prostate malignancies aggressively grow worldwide frequently occurring inoperable at diagnosis. A proper choice of treatment strategy is currently a challenge. Metastatic castration-resistant prostate cancer remains fatal and poor-prognosis, albeit the list of chemotherapeutic agents and androgen re...
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| Format: | Article |
| Language: | English |
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Bashkir State Medical University
2021-05-01
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| Series: | Креативная хирургия и онкология |
| Subjects: | |
| Online Access: | https://www.surgonco.ru/jour/article/view/589 |
| _version_ | 1797872353604009984 |
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| author | M. V. Loginova V. N. Pavlov I. R. Gilyazova |
| author_facet | M. V. Loginova V. N. Pavlov I. R. Gilyazova |
| author_sort | M. V. Loginova |
| collection | DOAJ |
| description | Prostate malignancies aggressively grow worldwide frequently occurring inoperable at diagnosis. A proper choice of treatment strategy is currently a challenge. Metastatic castration-resistant prostate cancer remains fatal and poor-prognosis, albeit the list of chemotherapeutic agents and androgen receptor signalling inhibitors has recently been extending towards a certain therapeutic success. Numerous studies suggest a frequent association of the unfavourable prognosis with germline or somatic damage of DNA repair genes. Such are mutations in the BRCA1 and BRCA2 genes bearing important clinical implications for the patient outcome through an adverse clinical manifest of primary tumours and poor treatment in metastatic castration-resistant prostate cancer. This review attempts to describe the BRCA1/2 mutations in prostate cancer with a focus on their prognostic value. |
| first_indexed | 2024-04-10T00:58:30Z |
| format | Article |
| id | doaj.art-7eddab9131b3441fae480bcf0de40e1b |
| institution | Directory Open Access Journal |
| issn | 2307-0501 2076-3093 |
| language | English |
| last_indexed | 2024-04-10T00:58:30Z |
| publishDate | 2021-05-01 |
| publisher | Bashkir State Medical University |
| record_format | Article |
| series | Креативная хирургия и онкология |
| spelling | doaj.art-7eddab9131b3441fae480bcf0de40e1b2023-03-13T10:01:10ZengBashkir State Medical UniversityКреативная хирургия и онкология2307-05012076-30932021-05-0111218318710.24060/2076-3093-2021-11-2-183-187434Prognostic Value of BRCA1 and BRCA2 Gene Mutations in Prostate Cancer: a Literature ReviewM. V. Loginova0V. N. Pavlov1I. R. Gilyazova2Республиканский клинический онкологический диспансер; Башкирский государственный медицинский университетБашкирский государственный медицинский университетИнститут биохимии и генетики Уфимского федерального исследовательского центра РАНProstate malignancies aggressively grow worldwide frequently occurring inoperable at diagnosis. A proper choice of treatment strategy is currently a challenge. Metastatic castration-resistant prostate cancer remains fatal and poor-prognosis, albeit the list of chemotherapeutic agents and androgen receptor signalling inhibitors has recently been extending towards a certain therapeutic success. Numerous studies suggest a frequent association of the unfavourable prognosis with germline or somatic damage of DNA repair genes. Such are mutations in the BRCA1 and BRCA2 genes bearing important clinical implications for the patient outcome through an adverse clinical manifest of primary tumours and poor treatment in metastatic castration-resistant prostate cancer. This review attempts to describe the BRCA1/2 mutations in prostate cancer with a focus on their prognostic value.https://www.surgonco.ru/jour/article/view/589рак предстательной железыгены brca1гены brca2метастатический кастрационно-резистентный ракднк репарациямутациязародышевой линии мутация |
| spellingShingle | M. V. Loginova V. N. Pavlov I. R. Gilyazova Prognostic Value of BRCA1 and BRCA2 Gene Mutations in Prostate Cancer: a Literature Review Креативная хирургия и онкология рак предстательной железы гены brca1 гены brca2 метастатический кастрационно-резистентный рак днк репарация мутация зародышевой линии мутация |
| title | Prognostic Value of BRCA1 and BRCA2 Gene Mutations in Prostate Cancer: a Literature Review |
| title_full | Prognostic Value of BRCA1 and BRCA2 Gene Mutations in Prostate Cancer: a Literature Review |
| title_fullStr | Prognostic Value of BRCA1 and BRCA2 Gene Mutations in Prostate Cancer: a Literature Review |
| title_full_unstemmed | Prognostic Value of BRCA1 and BRCA2 Gene Mutations in Prostate Cancer: a Literature Review |
| title_short | Prognostic Value of BRCA1 and BRCA2 Gene Mutations in Prostate Cancer: a Literature Review |
| title_sort | prognostic value of brca1 and brca2 gene mutations in prostate cancer a literature review |
| topic | рак предстательной железы гены brca1 гены brca2 метастатический кастрационно-резистентный рак днк репарация мутация зародышевой линии мутация |
| url | https://www.surgonco.ru/jour/article/view/589 |
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