Phloretin Prevents Diabetic Cardiomyopathy by Dissociating Keap1/Nrf2 Complex and Inhibiting Oxidative Stress

Phloretin Prevents Diabetic Cardiomyopathy by Dissociating Keap1/Nrf2 Complex and Inhibiting Oxidative Stress

Hyperglycemia induces chronic inflammation and oxidative stress in cardiomyocyte, which are the main pathological changes of diabetic cardiomyopathy (DCM). Treatment aimed at these processes may be beneficial in DCM. Phloretin (PHL), a promising natural product, has many pharmacological activities,...

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Bibliographic Details
Main Authors: Yin Ying, Jiye Jin, Li Ye, Pingping Sun, Hui Wang, Xiaodong Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Endocrinology
Subjects:
phloretin
Nrf2
Keap1
diabetic cardiomyopathy
oxidative stress
Online Access:https://www.frontiersin.org/article/10.3389/fendo.2018.00774/full

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