Validity and diagnostics of the Reading the Mind in the Eyes Test (RMET) in non-demented amyotrophic lateral sclerosis (ALS) patients
BackgroundThe aim of this study was to explore the construct validity and diagnostic properties of the Reading the Mind in the Eyes Test (RMET) in non-demented patients with amyotrophic lateral sclerosis (ALS).MaterialsA total of 61 consecutive patients and 50 healthy controls (HCs) were administere...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-11-01
|
| Series: | Frontiers in Psychology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyg.2022.1031841/full |
| _version_ | 1811255295562743808 |
|---|---|
| author | Edoardo Nicolò Aiello Edoardo Nicolò Aiello Laura Carelli Federica Solca Silvia Torre Roberta Ferrucci Roberta Ferrucci Roberta Ferrucci Alberto Priori Alberto Priori Federico Verde Federico Verde Vincenzo Silani Vincenzo Silani Nicola Ticozzi Nicola Ticozzi Barbara Poletti |
| author_facet | Edoardo Nicolò Aiello Edoardo Nicolò Aiello Laura Carelli Federica Solca Silvia Torre Roberta Ferrucci Roberta Ferrucci Roberta Ferrucci Alberto Priori Alberto Priori Federico Verde Federico Verde Vincenzo Silani Vincenzo Silani Nicola Ticozzi Nicola Ticozzi Barbara Poletti |
| author_sort | Edoardo Nicolò Aiello |
| collection | DOAJ |
| description | BackgroundThe aim of this study was to explore the construct validity and diagnostic properties of the Reading the Mind in the Eyes Test (RMET) in non-demented patients with amyotrophic lateral sclerosis (ALS).MaterialsA total of 61 consecutive patients and 50 healthy controls (HCs) were administered the 36-item RMET. Additionally, patients underwent a comprehensive assessment of social cognition via the Story-Based Empathy Task (SET), which encompasses three subtests targeting Causal Inference, Emotion Attribution (SET-EA), and Intention Attribution (SET-IA), as well as global cognitive [the Edinburgh Cognitive and Behavioral ALS Screen (ECAS)] and behavioral screening [the Frontal Behavioral Inventory (FBI); the Dimensional Apathy Scale (DAS); the Beck Depression Inventory (BDI); and the State and Trait Anxiety Inventory-Y]. The construct validity of the RMET was tested by regressing it within a stepwise model that encompassed as predictors the abovementioned cognitive and behavioral measures, covarying for demographic and motor confounders. Receiver-operating characteristics (ROC) analyses allowed exploring intrinsic and post-test properties of the RMET both in discriminating patients from HCs and in identifying patients with a defective SET-EA performance.ResultsThe RMET was solely predicted by the SET-EA (p = 0.003) and SET-IA (p = 0.005). RMET scores showed high accuracy both in discriminating patients from HCs (AUC = 0.81) and in identifying patients with a defective SET-EA score (AUC = 0.82), with adequate-to-optimal both intrinsic and post-test properties.DiscussionThe RMET is a convergently and divergently valid measure of affective social cognition in non-demented ALS patients, also featuring optimal intrinsic and post-test diagnostic properties in both case-control and case-finding scenarios. |
| first_indexed | 2024-04-12T17:21:47Z |
| format | Article |
| id | doaj.art-7ee03e85b0a74642991b9ce1a3f9b5bc |
| institution | Directory Open Access Journal |
| issn | 1664-1078 |
| language | English |
| last_indexed | 2024-04-12T17:21:47Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychology |
| spelling | doaj.art-7ee03e85b0a74642991b9ce1a3f9b5bc2022-12-22T03:23:27ZengFrontiers Media S.A.Frontiers in Psychology1664-10782022-11-011310.3389/fpsyg.2022.10318411031841Validity and diagnostics of the Reading the Mind in the Eyes Test (RMET) in non-demented amyotrophic lateral sclerosis (ALS) patientsEdoardo Nicolò Aiello0Edoardo Nicolò Aiello1Laura Carelli2Federica Solca3Silvia Torre4Roberta Ferrucci5Roberta Ferrucci6Roberta Ferrucci7Alberto Priori8Alberto Priori9Federico Verde10Federico Verde11Vincenzo Silani12Vincenzo Silani13Nicola Ticozzi14Nicola Ticozzi15Barbara Poletti16IRCCS Istituto Auxologico Italiano, Department of Neurology and Laboratory of Neuroscience, Milan, ItalyPh.D. Program in Neuroscience, School of Medicine and Surgery, University of Milano-Bicocca, Monza, ItalyIRCCS Istituto Auxologico Italiano, Department of Neurology and Laboratory of Neuroscience, Milan, ItalyIRCCS Istituto Auxologico Italiano, Department of Neurology and Laboratory of Neuroscience, Milan, ItalyIRCCS Istituto Auxologico Italiano, Department of Neurology and Laboratory of Neuroscience, Milan, ItalyAldo Ravelli Center for Neurotechnology and Experimental Brain Therapeutics, Department of Health Sciences, International Medical School, University of Milan, Milan, ItalyASST Santi Paolo e Carlo, San Paolo University Hospital, Milan, ItalyIRCCS Ca’ Granda Foundation Maggiore Policlinico Hospital, Milan, ItalyAldo Ravelli Center for Neurotechnology and Experimental Brain Therapeutics, Department of Health Sciences, International Medical School, University of Milan, Milan, ItalyASST Santi Paolo e Carlo, San Paolo University Hospital, Milan, ItalyIRCCS Istituto Auxologico Italiano, Department of Neurology and Laboratory of Neuroscience, Milan, Italy“Dino Ferrari” Center, Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Milan, ItalyIRCCS Istituto Auxologico Italiano, Department of Neurology and Laboratory of Neuroscience, Milan, Italy“Dino Ferrari” Center, Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Milan, ItalyIRCCS Istituto Auxologico Italiano, Department of Neurology and Laboratory of Neuroscience, Milan, Italy“Dino Ferrari” Center, Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Milan, ItalyIRCCS Istituto Auxologico Italiano, Department of Neurology and Laboratory of Neuroscience, Milan, ItalyBackgroundThe aim of this study was to explore the construct validity and diagnostic properties of the Reading the Mind in the Eyes Test (RMET) in non-demented patients with amyotrophic lateral sclerosis (ALS).MaterialsA total of 61 consecutive patients and 50 healthy controls (HCs) were administered the 36-item RMET. Additionally, patients underwent a comprehensive assessment of social cognition via the Story-Based Empathy Task (SET), which encompasses three subtests targeting Causal Inference, Emotion Attribution (SET-EA), and Intention Attribution (SET-IA), as well as global cognitive [the Edinburgh Cognitive and Behavioral ALS Screen (ECAS)] and behavioral screening [the Frontal Behavioral Inventory (FBI); the Dimensional Apathy Scale (DAS); the Beck Depression Inventory (BDI); and the State and Trait Anxiety Inventory-Y]. The construct validity of the RMET was tested by regressing it within a stepwise model that encompassed as predictors the abovementioned cognitive and behavioral measures, covarying for demographic and motor confounders. Receiver-operating characteristics (ROC) analyses allowed exploring intrinsic and post-test properties of the RMET both in discriminating patients from HCs and in identifying patients with a defective SET-EA performance.ResultsThe RMET was solely predicted by the SET-EA (p = 0.003) and SET-IA (p = 0.005). RMET scores showed high accuracy both in discriminating patients from HCs (AUC = 0.81) and in identifying patients with a defective SET-EA score (AUC = 0.82), with adequate-to-optimal both intrinsic and post-test properties.DiscussionThe RMET is a convergently and divergently valid measure of affective social cognition in non-demented ALS patients, also featuring optimal intrinsic and post-test diagnostic properties in both case-control and case-finding scenarios.https://www.frontiersin.org/articles/10.3389/fpsyg.2022.1031841/fullReading the Mind in the Eyes Testamyotrophic lateral sclerosisexecutivediagnosticspsychometric |
| spellingShingle | Edoardo Nicolò Aiello Edoardo Nicolò Aiello Laura Carelli Federica Solca Silvia Torre Roberta Ferrucci Roberta Ferrucci Roberta Ferrucci Alberto Priori Alberto Priori Federico Verde Federico Verde Vincenzo Silani Vincenzo Silani Nicola Ticozzi Nicola Ticozzi Barbara Poletti Validity and diagnostics of the Reading the Mind in the Eyes Test (RMET) in non-demented amyotrophic lateral sclerosis (ALS) patients Frontiers in Psychology Reading the Mind in the Eyes Test amyotrophic lateral sclerosis executive diagnostics psychometric |
| title | Validity and diagnostics of the Reading the Mind in the Eyes Test (RMET) in non-demented amyotrophic lateral sclerosis (ALS) patients |
| title_full | Validity and diagnostics of the Reading the Mind in the Eyes Test (RMET) in non-demented amyotrophic lateral sclerosis (ALS) patients |
| title_fullStr | Validity and diagnostics of the Reading the Mind in the Eyes Test (RMET) in non-demented amyotrophic lateral sclerosis (ALS) patients |
| title_full_unstemmed | Validity and diagnostics of the Reading the Mind in the Eyes Test (RMET) in non-demented amyotrophic lateral sclerosis (ALS) patients |
| title_short | Validity and diagnostics of the Reading the Mind in the Eyes Test (RMET) in non-demented amyotrophic lateral sclerosis (ALS) patients |
| title_sort | validity and diagnostics of the reading the mind in the eyes test rmet in non demented amyotrophic lateral sclerosis als patients |
| topic | Reading the Mind in the Eyes Test amyotrophic lateral sclerosis executive diagnostics psychometric |
| url | https://www.frontiersin.org/articles/10.3389/fpsyg.2022.1031841/full |
| work_keys_str_mv | AT edoardonicoloaiello validityanddiagnosticsofthereadingthemindintheeyestestrmetinnondementedamyotrophiclateralsclerosisalspatients AT edoardonicoloaiello validityanddiagnosticsofthereadingthemindintheeyestestrmetinnondementedamyotrophiclateralsclerosisalspatients AT lauracarelli validityanddiagnosticsofthereadingthemindintheeyestestrmetinnondementedamyotrophiclateralsclerosisalspatients AT federicasolca validityanddiagnosticsofthereadingthemindintheeyestestrmetinnondementedamyotrophiclateralsclerosisalspatients AT silviatorre validityanddiagnosticsofthereadingthemindintheeyestestrmetinnondementedamyotrophiclateralsclerosisalspatients AT robertaferrucci validityanddiagnosticsofthereadingthemindintheeyestestrmetinnondementedamyotrophiclateralsclerosisalspatients AT robertaferrucci validityanddiagnosticsofthereadingthemindintheeyestestrmetinnondementedamyotrophiclateralsclerosisalspatients AT robertaferrucci validityanddiagnosticsofthereadingthemindintheeyestestrmetinnondementedamyotrophiclateralsclerosisalspatients AT albertopriori validityanddiagnosticsofthereadingthemindintheeyestestrmetinnondementedamyotrophiclateralsclerosisalspatients AT albertopriori validityanddiagnosticsofthereadingthemindintheeyestestrmetinnondementedamyotrophiclateralsclerosisalspatients AT federicoverde validityanddiagnosticsofthereadingthemindintheeyestestrmetinnondementedamyotrophiclateralsclerosisalspatients AT federicoverde validityanddiagnosticsofthereadingthemindintheeyestestrmetinnondementedamyotrophiclateralsclerosisalspatients AT vincenzosilani validityanddiagnosticsofthereadingthemindintheeyestestrmetinnondementedamyotrophiclateralsclerosisalspatients AT vincenzosilani validityanddiagnosticsofthereadingthemindintheeyestestrmetinnondementedamyotrophiclateralsclerosisalspatients AT nicolaticozzi validityanddiagnosticsofthereadingthemindintheeyestestrmetinnondementedamyotrophiclateralsclerosisalspatients AT nicolaticozzi validityanddiagnosticsofthereadingthemindintheeyestestrmetinnondementedamyotrophiclateralsclerosisalspatients AT barbarapoletti validityanddiagnosticsofthereadingthemindintheeyestestrmetinnondementedamyotrophiclateralsclerosisalspatients |