An aggregon in conductin/axin2 regulates Wnt/β-catenin signaling and holds potential for cancer therapy
Polymerization of axin proteins is essential to suppress Wnt/β-catenin signaling. Here, the authors identify an aggregation site in the conductin/axin2 RGS domain that prevents its polymerization and show that a short peptide masking this aggregon promotes polymerization of conductin/axin2, downregu...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2019-09-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-12203-8 |
| _version_ | 1819040483659218944 |
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| author | Dominic B. Bernkopf Martina Brückner Michel V. Hadjihannas Jürgen Behrens |
| author_facet | Dominic B. Bernkopf Martina Brückner Michel V. Hadjihannas Jürgen Behrens |
| author_sort | Dominic B. Bernkopf |
| collection | DOAJ |
| description | Polymerization of axin proteins is essential to suppress Wnt/β-catenin signaling. Here, the authors identify an aggregation site in the conductin/axin2 RGS domain that prevents its polymerization and show that a short peptide masking this aggregon promotes polymerization of conductin/axin2, downregulation of Wnt pathway activity and growth inhibition of colorectal cancer cells. |
| first_indexed | 2024-12-21T09:09:49Z |
| format | Article |
| id | doaj.art-7ee0b10cbec64fbaa950ca92c1c59c9c |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-21T09:09:49Z |
| publishDate | 2019-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-7ee0b10cbec64fbaa950ca92c1c59c9c2022-12-21T19:09:15ZengNature PortfolioNature Communications2041-17232019-09-0110111410.1038/s41467-019-12203-8An aggregon in conductin/axin2 regulates Wnt/β-catenin signaling and holds potential for cancer therapyDominic B. Bernkopf0Martina Brückner1Michel V. Hadjihannas2Jürgen Behrens3Experimental Medicine II, Nikolaus-Fiebiger-Center, Friedrich-Alexander University Erlangen-NürnbergExperimental Medicine II, Nikolaus-Fiebiger-Center, Friedrich-Alexander University Erlangen-NürnbergExperimental Medicine II, Nikolaus-Fiebiger-Center, Friedrich-Alexander University Erlangen-NürnbergExperimental Medicine II, Nikolaus-Fiebiger-Center, Friedrich-Alexander University Erlangen-NürnbergPolymerization of axin proteins is essential to suppress Wnt/β-catenin signaling. Here, the authors identify an aggregation site in the conductin/axin2 RGS domain that prevents its polymerization and show that a short peptide masking this aggregon promotes polymerization of conductin/axin2, downregulation of Wnt pathway activity and growth inhibition of colorectal cancer cells.https://doi.org/10.1038/s41467-019-12203-8 |
| spellingShingle | Dominic B. Bernkopf Martina Brückner Michel V. Hadjihannas Jürgen Behrens An aggregon in conductin/axin2 regulates Wnt/β-catenin signaling and holds potential for cancer therapy Nature Communications |
| title | An aggregon in conductin/axin2 regulates Wnt/β-catenin signaling and holds potential for cancer therapy |
| title_full | An aggregon in conductin/axin2 regulates Wnt/β-catenin signaling and holds potential for cancer therapy |
| title_fullStr | An aggregon in conductin/axin2 regulates Wnt/β-catenin signaling and holds potential for cancer therapy |
| title_full_unstemmed | An aggregon in conductin/axin2 regulates Wnt/β-catenin signaling and holds potential for cancer therapy |
| title_short | An aggregon in conductin/axin2 regulates Wnt/β-catenin signaling and holds potential for cancer therapy |
| title_sort | aggregon in conductin axin2 regulates wnt β catenin signaling and holds potential for cancer therapy |
| url | https://doi.org/10.1038/s41467-019-12203-8 |
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