Mesenchymal stem cells reverse thymus aging by reprogramming the DNA methylation of thymic epithelial cells

Mesenchymal stem cells reverse thymus aging by reprogramming the DNA methylation of thymic epithelial cells

Background: A decrease in the number and activity of thymic epithelial cells (TECs) is an important factor in thymic degeneration. Mesenchymal stem cells (MSCs) treating thymic ageing is a promising strategy, but the DNA methylation modification mechanism in TECs remains unclear. Methods: Aged rhesu...

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Bibliographic Details
Main Authors: Zailing Yang, Chuan Tian, Zhixu He, Xiangqing Zhu, Jie He, Hang Pan, Ye Li, Guangping Ruan, XiJun Wu, Xinghua Pan
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Regenerative Therapy
Subjects:
Thymus aging
MSCs
TECs
DNA methylation
Online Access:http://www.sciencedirect.com/science/article/pii/S2352320424000397

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