Evolutionary trajectory of pattern recognition receptors in plants
Abstract Cell-surface receptors play pivotal roles in many biological processes, including immunity, development, and reproduction, across diverse organisms. How cell-surface receptors evolve to become specialised in different biological processes remains elusive. To shed light on the immune-specifi...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-02-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-023-44408-3 |
| _version_ | 1827326868064305152 |
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| author | Bruno Pok Man Ngou Michele Wyler Marc W. Schmid Yasuhiro Kadota Ken Shirasu |
| author_facet | Bruno Pok Man Ngou Michele Wyler Marc W. Schmid Yasuhiro Kadota Ken Shirasu |
| author_sort | Bruno Pok Man Ngou |
| collection | DOAJ |
| description | Abstract Cell-surface receptors play pivotal roles in many biological processes, including immunity, development, and reproduction, across diverse organisms. How cell-surface receptors evolve to become specialised in different biological processes remains elusive. To shed light on the immune-specificity of cell-surface receptors, we analyzed more than 200,000 genes encoding cell-surface receptors from 350 genomes and traced the evolutionary origin of immune-specific leucine-rich repeat receptor-like proteins (LRR-RLPs) in plants. Surprisingly, we discovered that the motifs crucial for co-receptor interaction in LRR-RLPs are closely related to those of the LRR-receptor-like kinase (RLK) subgroup Xb, which perceives phytohormones and primarily governs growth and development. Functional characterisation further reveals that LRR-RLPs initiate immune responses through their juxtamembrane and transmembrane regions, while LRR-RLK-Xb members regulate development through their cytosolic kinase domains. Our data suggest that the cell-surface receptors involved in immunity and development share a common origin. After diversification, their ectodomains, juxtamembrane, transmembrane, and cytosolic regions have either diversified or stabilised to recognise diverse ligands and activate differential downstream responses. Our work reveals a mechanism by which plants evolve to perceive diverse signals to activate the appropriate responses in a rapidly changing environment. |
| first_indexed | 2024-03-07T14:52:38Z |
| format | Article |
| id | doaj.art-7ee44b2afe7f46ca978802cd509e0042 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-03-07T14:52:38Z |
| publishDate | 2024-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-7ee44b2afe7f46ca978802cd509e00422024-03-05T19:38:13ZengNature PortfolioNature Communications2041-17232024-02-0115112210.1038/s41467-023-44408-3Evolutionary trajectory of pattern recognition receptors in plantsBruno Pok Man Ngou0Michele Wyler1Marc W. Schmid2Yasuhiro Kadota3Ken Shirasu4RIKEN Center for Sustainable Resource ScienceMWSchmid GmbHMWSchmid GmbHRIKEN Center for Sustainable Resource ScienceRIKEN Center for Sustainable Resource ScienceAbstract Cell-surface receptors play pivotal roles in many biological processes, including immunity, development, and reproduction, across diverse organisms. How cell-surface receptors evolve to become specialised in different biological processes remains elusive. To shed light on the immune-specificity of cell-surface receptors, we analyzed more than 200,000 genes encoding cell-surface receptors from 350 genomes and traced the evolutionary origin of immune-specific leucine-rich repeat receptor-like proteins (LRR-RLPs) in plants. Surprisingly, we discovered that the motifs crucial for co-receptor interaction in LRR-RLPs are closely related to those of the LRR-receptor-like kinase (RLK) subgroup Xb, which perceives phytohormones and primarily governs growth and development. Functional characterisation further reveals that LRR-RLPs initiate immune responses through their juxtamembrane and transmembrane regions, while LRR-RLK-Xb members regulate development through their cytosolic kinase domains. Our data suggest that the cell-surface receptors involved in immunity and development share a common origin. After diversification, their ectodomains, juxtamembrane, transmembrane, and cytosolic regions have either diversified or stabilised to recognise diverse ligands and activate differential downstream responses. Our work reveals a mechanism by which plants evolve to perceive diverse signals to activate the appropriate responses in a rapidly changing environment.https://doi.org/10.1038/s41467-023-44408-3 |
| spellingShingle | Bruno Pok Man Ngou Michele Wyler Marc W. Schmid Yasuhiro Kadota Ken Shirasu Evolutionary trajectory of pattern recognition receptors in plants Nature Communications |
| title | Evolutionary trajectory of pattern recognition receptors in plants |
| title_full | Evolutionary trajectory of pattern recognition receptors in plants |
| title_fullStr | Evolutionary trajectory of pattern recognition receptors in plants |
| title_full_unstemmed | Evolutionary trajectory of pattern recognition receptors in plants |
| title_short | Evolutionary trajectory of pattern recognition receptors in plants |
| title_sort | evolutionary trajectory of pattern recognition receptors in plants |
| url | https://doi.org/10.1038/s41467-023-44408-3 |
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