Anticancer effect of Moringa oleifera leaves extract against lung cancer cell line via induction of apoptosis
Since ancient times, Moringa oleifera has been a common vegetable in many nations. It has a large number of phenolic compounds with a diverse range of biological activity. It has anticancer properties that can be exploited to create novel medications for the treatment of various malignancies. The cu...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-12-01
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| Series: | Advances in Cancer Biology - Metastasis |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667394022000466 |
| _version_ | 1828168470509912064 |
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| author | Kinjal Bhadresha Vaidehi Thakore Jpan Brahmbhatt Vinal Upadhyay Nayan Jain Rakesh Rawal |
| author_facet | Kinjal Bhadresha Vaidehi Thakore Jpan Brahmbhatt Vinal Upadhyay Nayan Jain Rakesh Rawal |
| author_sort | Kinjal Bhadresha |
| collection | DOAJ |
| description | Since ancient times, Moringa oleifera has been a common vegetable in many nations. It has a large number of phenolic compounds with a diverse range of biological activity. It has anticancer properties that can be exploited to create novel medications for the treatment of various malignancies. The current study was conducted to evaluate the in vitro anticancer activities of M. oleifera leaves extracts. The M. oleifera leaves extracts significantly inhibited cell proliferation in the human cancer cell line A549 in a dose-dependent manner. Morphological studies indicated that the extract of moringa leaves stimulated apoptosis as demonstrated by cell shrinkage, blebbing, chromatin condensation, and nuclear fragmentation. Quantitative RT-PCR analyses of Bax and Bcl-2 showed abnormal expression profiles of these genes under various treatment conditions. This study demonstrates that M. oleifera leaves may have the ability to suppress the growth of cancer cells while also enhancing human health and developing new food ingredients. The phytochemicals from M. oleifera leaves can be employed as the primary medications to cure cancer, according to in vitro studies. |
| first_indexed | 2024-04-12T02:34:13Z |
| format | Article |
| id | doaj.art-7ee44d5b994d4957adc2365b7c203ce9 |
| institution | Directory Open Access Journal |
| issn | 2667-3940 |
| language | English |
| last_indexed | 2024-04-12T02:34:13Z |
| publishDate | 2022-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Advances in Cancer Biology - Metastasis |
| spelling | doaj.art-7ee44d5b994d4957adc2365b7c203ce92022-12-22T03:51:37ZengElsevierAdvances in Cancer Biology - Metastasis2667-39402022-12-016100072Anticancer effect of Moringa oleifera leaves extract against lung cancer cell line via induction of apoptosisKinjal Bhadresha0Vaidehi Thakore1Jpan Brahmbhatt2Vinal Upadhyay3Nayan Jain4Rakesh Rawal5Department of Life Sciences, School of Sciences, Gujarat University, Ahmedabad, 380009, India; Hematology/Oncology Division, School of Medicine, Indiana University, Indianapolis, IN, USADepartment of Life Sciences, School of Sciences, Gujarat University, Ahmedabad, 380009, IndiaDepartment of Life Sciences, School of Sciences, Gujarat University, Ahmedabad, 380009, IndiaDepartment of Life Sciences, School of Sciences, Gujarat University, Ahmedabad, 380009, IndiaDepartment of Life Sciences, School of Sciences, Gujarat University, Ahmedabad, 380009, IndiaDepartment of Life Sciences, School of Sciences, Gujarat University, Ahmedabad, 380009, India; Corresponding author.Since ancient times, Moringa oleifera has been a common vegetable in many nations. It has a large number of phenolic compounds with a diverse range of biological activity. It has anticancer properties that can be exploited to create novel medications for the treatment of various malignancies. The current study was conducted to evaluate the in vitro anticancer activities of M. oleifera leaves extracts. The M. oleifera leaves extracts significantly inhibited cell proliferation in the human cancer cell line A549 in a dose-dependent manner. Morphological studies indicated that the extract of moringa leaves stimulated apoptosis as demonstrated by cell shrinkage, blebbing, chromatin condensation, and nuclear fragmentation. Quantitative RT-PCR analyses of Bax and Bcl-2 showed abnormal expression profiles of these genes under various treatment conditions. This study demonstrates that M. oleifera leaves may have the ability to suppress the growth of cancer cells while also enhancing human health and developing new food ingredients. The phytochemicals from M. oleifera leaves can be employed as the primary medications to cure cancer, according to in vitro studies.http://www.sciencedirect.com/science/article/pii/S2667394022000466Moringa oleiferaAnticancer drugApoptosisLung cancer |
| spellingShingle | Kinjal Bhadresha Vaidehi Thakore Jpan Brahmbhatt Vinal Upadhyay Nayan Jain Rakesh Rawal Anticancer effect of Moringa oleifera leaves extract against lung cancer cell line via induction of apoptosis Advances in Cancer Biology - Metastasis Moringa oleifera Anticancer drug Apoptosis Lung cancer |
| title | Anticancer effect of Moringa oleifera leaves extract against lung cancer cell line via induction of apoptosis |
| title_full | Anticancer effect of Moringa oleifera leaves extract against lung cancer cell line via induction of apoptosis |
| title_fullStr | Anticancer effect of Moringa oleifera leaves extract against lung cancer cell line via induction of apoptosis |
| title_full_unstemmed | Anticancer effect of Moringa oleifera leaves extract against lung cancer cell line via induction of apoptosis |
| title_short | Anticancer effect of Moringa oleifera leaves extract against lung cancer cell line via induction of apoptosis |
| title_sort | anticancer effect of moringa oleifera leaves extract against lung cancer cell line via induction of apoptosis |
| topic | Moringa oleifera Anticancer drug Apoptosis Lung cancer |
| url | http://www.sciencedirect.com/science/article/pii/S2667394022000466 |
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