骨关节炎与2型糖尿病的风险:一项双样本孟德尔随机化分析
Abstract Background Physical inactivity is an independent risk factor for type 2 diabetes (T2D). Osteoarthritis (OA) is a common joint disease that limits patients' physical activity, which may increase risk of other chronic diseases including T2D. However, studies evaluating the effect of OA o...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-11-01
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| Series: | Journal of Diabetes |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/1753-0407.13451 |
| _version_ | 1797465782537420800 |
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| author | Xing Xing Yining Wang Faming Pan Guoqi Cai |
| author_facet | Xing Xing Yining Wang Faming Pan Guoqi Cai |
| author_sort | Xing Xing |
| collection | DOAJ |
| description | Abstract Background Physical inactivity is an independent risk factor for type 2 diabetes (T2D). Osteoarthritis (OA) is a common joint disease that limits patients' physical activity, which may increase risk of other chronic diseases including T2D. However, studies evaluating the effect of OA on T2D are scarce. This study aimed to investigate the causal effect of knee and hip OA on risk of T2D from a genetic perspective. Methods We performed two‐sample Mendelian randomization (MR) analyses to obtain nonconfounding estimates of the effect of OA on T2D risk. Single nucleotide polymorphisms (SNPs) from genome‐wide association studies were selected as genetic instruments for radiographic knee and hip OA (ie, Kellgren–Lawrence grade ≥2). The associations of these SNPs with T2D were evaluated in participants from the UK Biobank. Sensitivity analyses were conducted to test the robustness of the MR results. Results Genetic predisposition of knee but not hip OA was significantly associated with an increased risk of T2D (knee OA: odds ratio [OR] 1.18, 95% confidence interval (CI) 1.09–1.27, p <.001; hip OA: OR 1.04, 95% CI 0.94–1.16, p = .425). Sensitivity analyses showed that the main findings are robust. Conclusion The current study provides genetic evidence supporting that knee OA is a potential risk factor for T2D. |
| first_indexed | 2024-03-09T18:27:29Z |
| format | Article |
| id | doaj.art-7ee56401e1394a5f81eed446c70c1587 |
| institution | Directory Open Access Journal |
| issn | 1753-0393 1753-0407 |
| language | English |
| last_indexed | 2024-03-09T18:27:29Z |
| publishDate | 2023-11-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes |
| spelling | doaj.art-7ee56401e1394a5f81eed446c70c15872023-11-24T07:49:57ZengWileyJournal of Diabetes1753-03931753-04072023-11-01151198799310.1111/1753-0407.13451骨关节炎与2型糖尿病的风险:一项双样本孟德尔随机化分析Xing Xing0Yining Wang1Faming Pan2Guoqi Cai3Department of Epidemiology and Biostatistics, School of Public Health Anhui Medical University Hefei ChinaDepartment of Epidemiology and Biostatistics, School of Public Health Anhui Medical University Hefei ChinaDepartment of Epidemiology and Biostatistics, School of Public Health Anhui Medical University Hefei ChinaDepartment of Epidemiology and Biostatistics, School of Public Health Anhui Medical University Hefei ChinaAbstract Background Physical inactivity is an independent risk factor for type 2 diabetes (T2D). Osteoarthritis (OA) is a common joint disease that limits patients' physical activity, which may increase risk of other chronic diseases including T2D. However, studies evaluating the effect of OA on T2D are scarce. This study aimed to investigate the causal effect of knee and hip OA on risk of T2D from a genetic perspective. Methods We performed two‐sample Mendelian randomization (MR) analyses to obtain nonconfounding estimates of the effect of OA on T2D risk. Single nucleotide polymorphisms (SNPs) from genome‐wide association studies were selected as genetic instruments for radiographic knee and hip OA (ie, Kellgren–Lawrence grade ≥2). The associations of these SNPs with T2D were evaluated in participants from the UK Biobank. Sensitivity analyses were conducted to test the robustness of the MR results. Results Genetic predisposition of knee but not hip OA was significantly associated with an increased risk of T2D (knee OA: odds ratio [OR] 1.18, 95% confidence interval (CI) 1.09–1.27, p <.001; hip OA: OR 1.04, 95% CI 0.94–1.16, p = .425). Sensitivity analyses showed that the main findings are robust. Conclusion The current study provides genetic evidence supporting that knee OA is a potential risk factor for T2D.https://doi.org/10.1111/1753-0407.13451骨关节炎2型糖尿病代谢物孟德尔随机化 |
| spellingShingle | Xing Xing Yining Wang Faming Pan Guoqi Cai 骨关节炎与2型糖尿病的风险:一项双样本孟德尔随机化分析 Journal of Diabetes 骨关节炎 2型糖尿病 代谢物 孟德尔随机化 |
| title | 骨关节炎与2型糖尿病的风险:一项双样本孟德尔随机化分析 |
| title_full | 骨关节炎与2型糖尿病的风险:一项双样本孟德尔随机化分析 |
| title_fullStr | 骨关节炎与2型糖尿病的风险:一项双样本孟德尔随机化分析 |
| title_full_unstemmed | 骨关节炎与2型糖尿病的风险:一项双样本孟德尔随机化分析 |
| title_short | 骨关节炎与2型糖尿病的风险:一项双样本孟德尔随机化分析 |
| title_sort | 骨关节炎与2型糖尿病的风险 一项双样本孟德尔随机化分析 |
| topic | 骨关节炎 2型糖尿病 代谢物 孟德尔随机化 |
| url | https://doi.org/10.1111/1753-0407.13451 |
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