Impact of Astrocytic Coverage of Synapses on the Short-Term Memory of a Computational Neuron-Astrocyte Network
Working memory refers to the capability of the nervous system to selectively retain short-term memories in an active state. The long-standing viewpoint is that neurons play an indispensable role and working memory is encoded by synaptic plasticity. Furthermore, some recent studies have shown that ca...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-09-01
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| Series: | Mathematics |
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| Online Access: | https://www.mdpi.com/2227-7390/10/18/3275 |
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| author | Zonglun Li Yuliya Tsybina Susanna Gordleeva Alexey Zaikin |
| author_facet | Zonglun Li Yuliya Tsybina Susanna Gordleeva Alexey Zaikin |
| author_sort | Zonglun Li |
| collection | DOAJ |
| description | Working memory refers to the capability of the nervous system to selectively retain short-term memories in an active state. The long-standing viewpoint is that neurons play an indispensable role and working memory is encoded by synaptic plasticity. Furthermore, some recent studies have shown that calcium signaling assists the memory processes and the working memory might be affected by the astrocyte density. Over the last few decades, growing evidence has also revealed that astrocytes exhibit diverse coverage of synapses which are considered to participate in neuronal activities. However, very little effort has yet been made to attempt to shed light on the potential correlations between these observations. Hence, in this article, we leverage a computational neuron–astrocyte model to study the short-term memory performance subject to various astrocytic coverage and we demonstrate that the short-term memory is susceptible to this factor. Our model may also provide plausible hypotheses for the various sizes of calcium events as they are reckoned to be correlated with the astrocytic coverage. |
| first_indexed | 2024-03-09T23:15:39Z |
| format | Article |
| id | doaj.art-7ee5dde1193e41dab2a2335c10d8bc34 |
| institution | Directory Open Access Journal |
| issn | 2227-7390 |
| language | English |
| last_indexed | 2024-03-09T23:15:39Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Mathematics |
| spelling | doaj.art-7ee5dde1193e41dab2a2335c10d8bc342023-11-23T17:35:45ZengMDPI AGMathematics2227-73902022-09-011018327510.3390/math10183275Impact of Astrocytic Coverage of Synapses on the Short-Term Memory of a Computational Neuron-Astrocyte NetworkZonglun Li0Yuliya Tsybina1Susanna Gordleeva2Alexey Zaikin3Department of Mathematics, University College London, London WC1E 6BT, UKDepartment of Neurotechnology, Lobachevsky State University of Nizhny Novgorod, 603022 Nizhny Novgorod, RussiaDepartment of Neurotechnology, Lobachevsky State University of Nizhny Novgorod, 603022 Nizhny Novgorod, RussiaDepartment of Mathematics, University College London, London WC1E 6BT, UKWorking memory refers to the capability of the nervous system to selectively retain short-term memories in an active state. The long-standing viewpoint is that neurons play an indispensable role and working memory is encoded by synaptic plasticity. Furthermore, some recent studies have shown that calcium signaling assists the memory processes and the working memory might be affected by the astrocyte density. Over the last few decades, growing evidence has also revealed that astrocytes exhibit diverse coverage of synapses which are considered to participate in neuronal activities. However, very little effort has yet been made to attempt to shed light on the potential correlations between these observations. Hence, in this article, we leverage a computational neuron–astrocyte model to study the short-term memory performance subject to various astrocytic coverage and we demonstrate that the short-term memory is susceptible to this factor. Our model may also provide plausible hypotheses for the various sizes of calcium events as they are reckoned to be correlated with the astrocytic coverage.https://www.mdpi.com/2227-7390/10/18/3275neuronastrocytenetworkshort-term memoryspatial frequencycomputational biology |
| spellingShingle | Zonglun Li Yuliya Tsybina Susanna Gordleeva Alexey Zaikin Impact of Astrocytic Coverage of Synapses on the Short-Term Memory of a Computational Neuron-Astrocyte Network Mathematics neuron astrocyte network short-term memory spatial frequency computational biology |
| title | Impact of Astrocytic Coverage of Synapses on the Short-Term Memory of a Computational Neuron-Astrocyte Network |
| title_full | Impact of Astrocytic Coverage of Synapses on the Short-Term Memory of a Computational Neuron-Astrocyte Network |
| title_fullStr | Impact of Astrocytic Coverage of Synapses on the Short-Term Memory of a Computational Neuron-Astrocyte Network |
| title_full_unstemmed | Impact of Astrocytic Coverage of Synapses on the Short-Term Memory of a Computational Neuron-Astrocyte Network |
| title_short | Impact of Astrocytic Coverage of Synapses on the Short-Term Memory of a Computational Neuron-Astrocyte Network |
| title_sort | impact of astrocytic coverage of synapses on the short term memory of a computational neuron astrocyte network |
| topic | neuron astrocyte network short-term memory spatial frequency computational biology |
| url | https://www.mdpi.com/2227-7390/10/18/3275 |
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