Advantages and Disadvantages of Methadone among Children and Adults: A Systematic Review and Meta-Analysis
<br /> <span style="font-size: x-small;">Background: Today, an increasing trend to methadone as an alternative maintenance treatment for opiate dependence in adults is observed; children for both intentional and accidental reasons are exposed to serious and fetal effects of met...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Mashhad University of Medical Sciences
2019-09-01
|
| Series: | International Journal of Pediatrics |
| Subjects: | |
| Online Access: | http://ijp.mums.ac.ir/article_13507_47fbd3cc2ba625f13f42a38aabe1d471.pdf |
| _version_ | 1811187268959862784 |
|---|---|
| author | Masoudeh Babakhanian Kaveh Mousavi Kani Hoda Shojaei Robabeh Mousavi nezhad Farideh Daneshvar Kourosh Sayehmiri Shahrzad Khosravifar Shaghayegh Khosravifar Abolfazl Fattah Masumeh Ghazanfarpour Firoozeh Mirzaee |
| author_facet | Masoudeh Babakhanian Kaveh Mousavi Kani Hoda Shojaei Robabeh Mousavi nezhad Farideh Daneshvar Kourosh Sayehmiri Shahrzad Khosravifar Shaghayegh Khosravifar Abolfazl Fattah Masumeh Ghazanfarpour Firoozeh Mirzaee |
| author_sort | Masoudeh Babakhanian |
| collection | DOAJ |
| description | <br /> <span style="font-size: x-small;">Background: Today, an increasing trend to methadone as an alternative maintenance treatment for opiate dependence in adults is observed; children for both intentional and accidental reasons are exposed to serious and fetal effects of methadone. We aimed to investigate effects of methadone on children and sexual functioning among adults in Iranian population.</span><br /> <span style="font-size: x-small;">Materials and Methods: An extensive search was done in databases of Medline, EMBASE, Scopus, Cochrane, and Web of Science until August 2018. Two independent researchers screened articles, and categorized them based on the evaluated outcomes and overall effect size was presented. After excluding the duplicated, irrelevant and low-quality articles, eligible ones were enrolled in the meta-analysis. Finally, pooled effect size was presented as standardized mean difference (SMD) or pooled prevalence with 95% confidence interval (95% CI). </span><br /> <span style="font-size: x-small;">Results: Methadone was found to be more effective than morphine on neonatal abstinence syndrome. The first four most common symptoms of methadone poisoning were loss of consciousness (81%), sleepiness (72%), meiotic pupils (76%), vomiting (56%), and Apnea (48%). The overall prevalence rate of sexual disorders and erectile dysfunction was 66.3% and 77.5%, respectively. The subjects in methadone group were over 2.5-fold more likely to use condom during intercourse (p<0.001). The methadone therapy could lead to a significant reduction in orgasm functioning (p<0.001), and a significant improvement in libido (p=0.001). The methadone maintenance treatment (MMT) significantly resulted in decreased orgasm function and improved libido in males.</span><br /> <span style="font-size: x-small;">Conclusion: Evidence suggests a positive impact of methadone maintenance treatment on risky sexual behaviors. Regarding the methadone poisoning effect on children, people should be informed by health care providers about serious and fetal effects on children.</span> |
| first_indexed | 2024-04-11T14:00:36Z |
| format | Article |
| id | doaj.art-7ee78cbf2dfa459b97eceae8ded813e7 |
| institution | Directory Open Access Journal |
| issn | 2345-5047 2345-5055 |
| language | English |
| last_indexed | 2024-04-11T14:00:36Z |
| publishDate | 2019-09-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | International Journal of Pediatrics |
| spelling | doaj.art-7ee78cbf2dfa459b97eceae8ded813e72022-12-22T04:20:09ZengMashhad University of Medical SciencesInternational Journal of Pediatrics2345-50472345-50552019-09-0179101251013710.22038/ijp.2019.41697.351113507Advantages and Disadvantages of Methadone among Children and Adults: A Systematic Review and Meta-AnalysisMasoudeh Babakhanian0Kaveh Mousavi Kani1Hoda Shojaei2Robabeh Mousavi nezhad3Farideh Daneshvar4Kourosh Sayehmiri5Shahrzad Khosravifar6Shaghayegh Khosravifar7Abolfazl Fattah8Masumeh Ghazanfarpour9Firoozeh Mirzaee10Social Determinants of Health Research Center, Semnan University of Medical Sciences, Semnan, Iran.Head and Neck Research Center, Facial plastic surgery division, Tehran University of Medical Science, Tehran, Iran.Pediatrician, Department of Pediatrics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.Pediatrician, Department of Pediatrics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.Department of Anesthesiology, Mashhad University of Medical Sciences, Mashhad, Iran.Psychosocial Injouries Research Center, Ilam University of Medical Sciences, Ilam, Iran.Psychiatrist, Fellowship of Sleep Medicine, Rasool Akram Hospital, Iran University of Medical Science, Tehran, Iran.Resident of Psychiatry, Isfahan University of medical science. Isfahan, Iran.Semnan University of Medical Science, Semnan, Iran.Nursing Research Center, Kerman University of Medical Sciences, Kerman, Iran.Nursing Research Center, Kerman University of Medical Sciences, Kerman, Iran.<br /> <span style="font-size: x-small;">Background: Today, an increasing trend to methadone as an alternative maintenance treatment for opiate dependence in adults is observed; children for both intentional and accidental reasons are exposed to serious and fetal effects of methadone. We aimed to investigate effects of methadone on children and sexual functioning among adults in Iranian population.</span><br /> <span style="font-size: x-small;">Materials and Methods: An extensive search was done in databases of Medline, EMBASE, Scopus, Cochrane, and Web of Science until August 2018. Two independent researchers screened articles, and categorized them based on the evaluated outcomes and overall effect size was presented. After excluding the duplicated, irrelevant and low-quality articles, eligible ones were enrolled in the meta-analysis. Finally, pooled effect size was presented as standardized mean difference (SMD) or pooled prevalence with 95% confidence interval (95% CI). </span><br /> <span style="font-size: x-small;">Results: Methadone was found to be more effective than morphine on neonatal abstinence syndrome. The first four most common symptoms of methadone poisoning were loss of consciousness (81%), sleepiness (72%), meiotic pupils (76%), vomiting (56%), and Apnea (48%). The overall prevalence rate of sexual disorders and erectile dysfunction was 66.3% and 77.5%, respectively. The subjects in methadone group were over 2.5-fold more likely to use condom during intercourse (p<0.001). The methadone therapy could lead to a significant reduction in orgasm functioning (p<0.001), and a significant improvement in libido (p=0.001). The methadone maintenance treatment (MMT) significantly resulted in decreased orgasm function and improved libido in males.</span><br /> <span style="font-size: x-small;">Conclusion: Evidence suggests a positive impact of methadone maintenance treatment on risky sexual behaviors. Regarding the methadone poisoning effect on children, people should be informed by health care providers about serious and fetal effects on children.</span>http://ijp.mums.ac.ir/article_13507_47fbd3cc2ba625f13f42a38aabe1d471.pdfChildrenIranmethadoneMeta-analysisPoisoningSexual functioning |
| spellingShingle | Masoudeh Babakhanian Kaveh Mousavi Kani Hoda Shojaei Robabeh Mousavi nezhad Farideh Daneshvar Kourosh Sayehmiri Shahrzad Khosravifar Shaghayegh Khosravifar Abolfazl Fattah Masumeh Ghazanfarpour Firoozeh Mirzaee Advantages and Disadvantages of Methadone among Children and Adults: A Systematic Review and Meta-Analysis International Journal of Pediatrics Children Iran methadone Meta-analysis Poisoning Sexual functioning |
| title | Advantages and Disadvantages of Methadone among Children and Adults: A Systematic Review and Meta-Analysis |
| title_full | Advantages and Disadvantages of Methadone among Children and Adults: A Systematic Review and Meta-Analysis |
| title_fullStr | Advantages and Disadvantages of Methadone among Children and Adults: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | Advantages and Disadvantages of Methadone among Children and Adults: A Systematic Review and Meta-Analysis |
| title_short | Advantages and Disadvantages of Methadone among Children and Adults: A Systematic Review and Meta-Analysis |
| title_sort | advantages and disadvantages of methadone among children and adults a systematic review and meta analysis |
| topic | Children Iran methadone Meta-analysis Poisoning Sexual functioning |
| url | http://ijp.mums.ac.ir/article_13507_47fbd3cc2ba625f13f42a38aabe1d471.pdf |
| work_keys_str_mv | AT masoudehbabakhanian advantagesanddisadvantagesofmethadoneamongchildrenandadultsasystematicreviewandmetaanalysis AT kavehmousavikani advantagesanddisadvantagesofmethadoneamongchildrenandadultsasystematicreviewandmetaanalysis AT hodashojaei advantagesanddisadvantagesofmethadoneamongchildrenandadultsasystematicreviewandmetaanalysis AT robabehmousavinezhad advantagesanddisadvantagesofmethadoneamongchildrenandadultsasystematicreviewandmetaanalysis AT faridehdaneshvar advantagesanddisadvantagesofmethadoneamongchildrenandadultsasystematicreviewandmetaanalysis AT kouroshsayehmiri advantagesanddisadvantagesofmethadoneamongchildrenandadultsasystematicreviewandmetaanalysis AT shahrzadkhosravifar advantagesanddisadvantagesofmethadoneamongchildrenandadultsasystematicreviewandmetaanalysis AT shaghayeghkhosravifar advantagesanddisadvantagesofmethadoneamongchildrenandadultsasystematicreviewandmetaanalysis AT abolfazlfattah advantagesanddisadvantagesofmethadoneamongchildrenandadultsasystematicreviewandmetaanalysis AT masumehghazanfarpour advantagesanddisadvantagesofmethadoneamongchildrenandadultsasystematicreviewandmetaanalysis AT firoozehmirzaee advantagesanddisadvantagesofmethadoneamongchildrenandadultsasystematicreviewandmetaanalysis |