Distinct Local and Systemic Molecular Signatures in the Esophageal and Gastric Cancers: Possible Therapy Targets and Biomarkers for Gastric Cancer

Distinct Local and Systemic Molecular Signatures in the Esophageal and Gastric Cancers: Possible Therapy Targets and Biomarkers for Gastric Cancer

Gastric (GC) and esophageal (EC) cancers are highly lethal. Better understanding of molecular abnormalities is needed for new therapeutic targets and biomarkers to be found. Expression of 18 cancer-related genes in 31 paired normal-tumor samples was quantified by reversely-transcribed quantitative p...

Full description

Bibliographic Details
Main Authors:	Iwona Bednarz-Misa, Paulina Fortuna, Dorota Diakowska, Natalia Jamrozik, Małgorzata Krzystek-Korpacka
Format:	Article
Language:	English
Published:	MDPI AG 2020-06-01
Series:	International Journal of Molecular Sciences
Subjects:	cardia cancer esophageal cancer epithelial-mesenchymal transition tight junction proteins claudin-2 differential biomarkers
Online Access:	https://www.mdpi.com/1422-0067/21/12/4509

Similar Items

Local and Systemic Interleukin-32 in Esophageal, Gastric, and Colorectal Cancers: Clinical and Diagnostic Significance
by: Dorota Diakowska, et al.
Published: (2020-10-01)

Claudin-4: A New Molecular Target for Epithelial Cancer Therapy
by: Rina Fujiwara-Tani, et al.
Published: (2023-03-01)

Local and Systemic IL-7 Concentration in Gastrointestinal-Tract Cancers
by: Iwona Bednarz-Misa, et al.
Published: (2019-06-01)

Claudins: New Players in Human Fertility and Reproductive System Cancers
by: Marta Justyna Kozieł, et al.
Published: (2020-03-01)

Functional Analysis of Gastric Tight Junction Proteins in <i>Xenopus laevis</i> Oocytes
by: Laura Stein, et al.
Published: (2022-07-01)

Interleukins 4 and 13 and Their Receptors Are Differently Expressed in Gastrointestinal Tract Cancers, Depending on the Anatomical Site and Disease Advancement, and Improve Colon Cancer Cell Viability and Motility
by: Iwona Bednarz-Misa, et al.
Published: (2020-06-01)

Reconstitution of functional tight junctions with individual claudin subtypes in epithelial cells
by: Mikio Furuse, et al.
Published: (2022-12-01)

Hypomethylation of <i>CLDN4</i> Gene Promoter Is Associated with Malignant Phenotype in Urinary Bladder Cancer
by: Fumisato Maesaka, et al.
Published: (2022-06-01)

Barriers and channels formed by tight junction proteins II /
by: Fromm, Michael, et al.
Published: (2012)

Role of tight junction proteins in gastroesophageal reflux disease
by: Mönkemüller Klaus, et al.
Published: (2012-09-01)

Cannabidiol Strengthening of Gastric Tight Junction Complexes Analyzed in an Improved <i>Xenopus</i> Oocyte Assay
by: Laura Stein, et al.
Published: (2024-01-01)

The tight junction protein claudin 6 is a potential target for patient-individualized treatment in esophageal and gastric adenocarcinoma and is associated with poor prognosis
by: Adrian Georg Simon, et al.
Published: (2023-08-01)

Prognostic Significance of Aberrant Claudin-6 Expression in Endometrial Cancer
by: Manabu Kojima, et al.
Published: (2020-09-01)

Emerging clinical significance of claudin-7 in colorectal cancer: a review
by: Wang K, et al.
Published: (2018-09-01)

Cinnamic Acid and Caffeic Acid Effects on Gastric Tight Junction Proteins Analyzed in <i>Xenopus laevis</i> Oocytes
by: Marie-Luise Vollstädt, et al.
Published: (2024-02-01)

Racial and ethnic disparities in mortality from gastric and esophageal adenocarcinoma
by: Monika Laszkowska, et al.
Published: (2020-08-01)

Beyond Chemotherapy, PD-1, and HER-2: Novel Targets for Gastric and Esophageal Cancer
by: Ali Zubair Siddiqui, et al.
Published: (2021-08-01)

The Distinct Impact of TAM Infiltration on the Prognosis of Patients With Cardia and Non-Cardia Gastric Cancer and Its Association With H. pylori Infection
by: Min Liu, et al.
Published: (2021-12-01)

Barrier Perturbation in Porcine Peyer’s Patches by Tumor Necrosis Factor is Associated With a Dysregulation of Claudins
by: Linda Droessler, et al.
Published: (2022-05-01)

RETRACTED ARTICLE: Differences in the expression profiles of claudin proteins in human nasopharyngeal carcinoma compared with non-neoplastic mucosa
by: Xiaowei Zhang, et al.
Published: (2018-02-01)

Tight Junction Proteins and Signaling Pathways in Cancer and Inflammation: A Functional Crosstalk
by: Ajaz A. Bhat, et al.
Published: (2019-01-01)

The Distinctive Serum Metabolomes of Gastric, Esophageal and Colorectal Cancers
by: Zhenxing Ren, et al.
Published: (2021-02-01)

Non-tight junction-related function of claudin-7 in interacting with integrinβ1 to suppress colorectal cancer cell proliferation and migration
by: Li W, et al.
Published: (2019-02-01)

Altered L-Arginine Metabolic Pathways in Gastric Cancer: Potential Therapeutic Targets and Biomarkers
by: Iwona Bednarz-Misa, et al.
Published: (2021-07-01)

Quercetin Improves Barrier Properties in Porcine Small Intestine but Not in Peyer’s Patches
by: Valeria Cornelius, et al.
Published: (2024-01-01)

Cannabidiol attenuates inflammatory impairment of intestinal cells expanding biomaterial-based therapeutic approaches
by: Elisa Boehm, et al.
Published: (2023-12-01)

Reduced Claudin-12 Expression Predicts Poor Prognosis in Cervical Cancer
by: Abidur Rahman, et al.
Published: (2021-04-01)

miR-195-5p Regulates Tight Junctions Expression via Claudin-2 Downregulation in Ulcerative Colitis
by: Viviana Scalavino, et al.
Published: (2022-04-01)

Intestinal Barrier, Claudins and Mycotoxins
by: Marta Justyna Kozieł, et al.
Published: (2021-10-01)

Tight junction physiology of pleural mesothelium
by: Alexander G. Markov, et al.
Published: (2014-06-01)

Serological assessment of gastric mucosal atrophy in gastric cancer
by: Bornschein Jan, et al.
Published: (2012-01-01)

Current Role of Immunotherapy in Gastric, Esophageal and Gastro-Esophageal Junction Cancers—A Report from the Western Canadian Gastrointestinal Cancer Consensus Conference
by: Karen Mulder, et al.
Published: (2022-04-01)

High glucose levels increase influenza-associated damage to the pulmonary epithelial-endothelial barrier
by: Katina D Hulme, et al.
Published: (2020-07-01)

The ESCRT machinery regulates retromer-dependent transcytosis of septate junction components in Drosophila
by: Hendrik Pannen, et al.
Published: (2020-12-01)

Role of airway epithelial barrier dysfunction in pathogenesis of asthma
by: Yasuhiro Gon, et al.
Published: (2018-01-01)

Claudins and Gastric Cancer: An Overview
by: Itaru Hashimoto, et al.
Published: (2022-01-01)

Alterations of Gastric Microbiota in Gastric Cancer and Precancerous Stages
by: Xinmei Zhang, et al.
Published: (2021-03-01)

Site-Specific Variation in Familial Cancer as Suggested by Family History, Multiple Primary Cancer, Age at Onset, and Sex Ratio Associated With Upper, Middle, and Lower Third Esophageal and Gastric Cardia Carcinoma
by: Denggui Wen, et al.
Published: (2020-10-01)

Trends of gastric cancer burdens attributable to risk factors in China from 2000 to 2050Research in context
by: Feifan He, et al.
Published: (2024-03-01)

Trends in gastric cancer mortality 1990–2019 in 36 countries worldwide, with predictions to 2025, and incidence, overall and by subtype
by: Giulia Collatuzzo, et al.
Published: (2023-04-01)