The Role of Dyslipidemia in Periodontitis
Studies have suggested an important role of dyslipidemia, a condition with alterations in blood lipid levels, in promoting an additional effect on periodontal breakdown. Thus, this study aimed to explore the theoretical pathways associated with dyslipidemia and periodontitis. We used data from 11,91...
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| Format: | Article |
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MDPI AG
2023-01-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/15/2/300 |
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| author | Fernando Valentim Bitencourt Gustavo G. Nascimento Susilena Arouche Costa Silvana Regina Perez Orrico Cecilia Claudia Costa Ribeiro Fábio Renato Manzolli Leite |
| author_facet | Fernando Valentim Bitencourt Gustavo G. Nascimento Susilena Arouche Costa Silvana Regina Perez Orrico Cecilia Claudia Costa Ribeiro Fábio Renato Manzolli Leite |
| author_sort | Fernando Valentim Bitencourt |
| collection | DOAJ |
| description | Studies have suggested an important role of dyslipidemia, a condition with alterations in blood lipid levels, in promoting an additional effect on periodontal breakdown. Thus, this study aimed to explore the theoretical pathways associated with dyslipidemia and periodontitis. We used data from 11,917 US adults with complete periodontal examinations participating in the Third National Health and Nutrition Examination Survey (NHANES III). Our hypothesis was tested using structural equation modelling (SEM). Dyslipidemia was defined according to the National Cholesterol Education Program (NCEP-ATP III) and periodontitis as a latent variable reflecting the shared variance of the number of surfaces with periodontal pocket depth [PPD] = 4 mm, PPD = 5 mm, PPD ≥ 6 mm, clinical attachment level [CAL] = 4 mm, CAL = 5mm, CAL ≥ 6 mm, and furcation involvement. The model also considered distal determinants (age, sex, and socioeconomic status) and proximal determinants (HbA1c, smoking and alcohol consumption, and obesity). The model showed sufficient global fit (Root Mean Squared Error of Approximation = 0.04, 90%CI = 0.04–0.05, Tucker–Lewis Index = 0.93, Comparative Fit Index = 0.95). Age, sex, socioeconomic status, obesity, and smoking were directly associated with periodontitis (<i>p</i> < 0.01). Dyslipidemia revealed a significant direct effect on periodontitis (standardized coefficient [SC] = 0.086, SE 0.027; <i>p</i> < 0.01), also mediated via an indirect pathway through HbA1c (SC = 0.021; SE 0.010; <i>p</i> = 0.02) and obesity (SC = 0.036; SE 0.012; <i>p</i> < 0.01) and resulted in a total effect on periodontitis. Dyslipidemia was associated with periodontitis through a direct pathway and indirectly through HbA1c and obesity in the US population. These results support the need for a multi-professional approach to tackling oral and noncommunicable diseases (NCDs), directed at their common risk factors. |
| first_indexed | 2024-03-09T11:31:43Z |
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| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-09T11:31:43Z |
| publishDate | 2023-01-01 |
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| spelling | doaj.art-7ee84024181c452d94ca833c09f428f52023-11-30T23:49:40ZengMDPI AGNutrients2072-66432023-01-0115230010.3390/nu15020300The Role of Dyslipidemia in PeriodontitisFernando Valentim Bitencourt0Gustavo G. Nascimento1Susilena Arouche Costa2Silvana Regina Perez Orrico3Cecilia Claudia Costa Ribeiro4Fábio Renato Manzolli Leite5Department of Dentistry and Oral Health, Section for Periodontology, Aarhus University, 8000 Aarhus, DenmarkDepartment of Dentistry and Oral Health, Section for Periodontology, Aarhus University, 8000 Aarhus, DenmarkDepartment of Dentistry and Oral Health, Section for Periodontology, Aarhus University, 8000 Aarhus, DenmarkDepartment of Diagnosis and Surgery, School of Dentistry at Araraquara, São Paulo State University (UNESP), Araraquara 14801385, BrazilGraduate Dentistry Program, Federal University of Maranhão, São Luís 65080805, BrazilDepartment of Dentistry and Oral Health, Section for Periodontology, Aarhus University, 8000 Aarhus, DenmarkStudies have suggested an important role of dyslipidemia, a condition with alterations in blood lipid levels, in promoting an additional effect on periodontal breakdown. Thus, this study aimed to explore the theoretical pathways associated with dyslipidemia and periodontitis. We used data from 11,917 US adults with complete periodontal examinations participating in the Third National Health and Nutrition Examination Survey (NHANES III). Our hypothesis was tested using structural equation modelling (SEM). Dyslipidemia was defined according to the National Cholesterol Education Program (NCEP-ATP III) and periodontitis as a latent variable reflecting the shared variance of the number of surfaces with periodontal pocket depth [PPD] = 4 mm, PPD = 5 mm, PPD ≥ 6 mm, clinical attachment level [CAL] = 4 mm, CAL = 5mm, CAL ≥ 6 mm, and furcation involvement. The model also considered distal determinants (age, sex, and socioeconomic status) and proximal determinants (HbA1c, smoking and alcohol consumption, and obesity). The model showed sufficient global fit (Root Mean Squared Error of Approximation = 0.04, 90%CI = 0.04–0.05, Tucker–Lewis Index = 0.93, Comparative Fit Index = 0.95). Age, sex, socioeconomic status, obesity, and smoking were directly associated with periodontitis (<i>p</i> < 0.01). Dyslipidemia revealed a significant direct effect on periodontitis (standardized coefficient [SC] = 0.086, SE 0.027; <i>p</i> < 0.01), also mediated via an indirect pathway through HbA1c (SC = 0.021; SE 0.010; <i>p</i> = 0.02) and obesity (SC = 0.036; SE 0.012; <i>p</i> < 0.01) and resulted in a total effect on periodontitis. Dyslipidemia was associated with periodontitis through a direct pathway and indirectly through HbA1c and obesity in the US population. These results support the need for a multi-professional approach to tackling oral and noncommunicable diseases (NCDs), directed at their common risk factors.https://www.mdpi.com/2072-6643/15/2/300diabetes mellitusdyslipidemiasnon-communicable diseasesperiodontal diseasespublic health dentistrysystemic disease |
| spellingShingle | Fernando Valentim Bitencourt Gustavo G. Nascimento Susilena Arouche Costa Silvana Regina Perez Orrico Cecilia Claudia Costa Ribeiro Fábio Renato Manzolli Leite The Role of Dyslipidemia in Periodontitis Nutrients diabetes mellitus dyslipidemias non-communicable diseases periodontal diseases public health dentistry systemic disease |
| title | The Role of Dyslipidemia in Periodontitis |
| title_full | The Role of Dyslipidemia in Periodontitis |
| title_fullStr | The Role of Dyslipidemia in Periodontitis |
| title_full_unstemmed | The Role of Dyslipidemia in Periodontitis |
| title_short | The Role of Dyslipidemia in Periodontitis |
| title_sort | role of dyslipidemia in periodontitis |
| topic | diabetes mellitus dyslipidemias non-communicable diseases periodontal diseases public health dentistry systemic disease |
| url | https://www.mdpi.com/2072-6643/15/2/300 |
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