Marine biomaterials in biomedical nano/micro-systems
Abstract Marine resources in unique marine environments provide abundant, cost-effective natural biomaterials with distinct structures, compositions, and biological activities compared to terrestrial species. These marine-derived raw materials, including polysaccharides, natural protein components,...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-11-01
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| Series: | Journal of Nanobiotechnology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12951-023-02112-w |
| _version_ | 1797629960874098688 |
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| author | Yanan Wang Long Chen Yuanzheng Wang Xinyuan Wang Deyao Qian Jiahui Yan Zeyu Sun Pengfei Cui Liangmin Yu Jun Wu Zhiyu He |
| author_facet | Yanan Wang Long Chen Yuanzheng Wang Xinyuan Wang Deyao Qian Jiahui Yan Zeyu Sun Pengfei Cui Liangmin Yu Jun Wu Zhiyu He |
| author_sort | Yanan Wang |
| collection | DOAJ |
| description | Abstract Marine resources in unique marine environments provide abundant, cost-effective natural biomaterials with distinct structures, compositions, and biological activities compared to terrestrial species. These marine-derived raw materials, including polysaccharides, natural protein components, fatty acids, and marine minerals, etc., have shown great potential in preparing, stabilizing, or modifying multifunctional nano-/micro-systems and are widely applied in drug delivery, theragnostic, tissue engineering, etc. This review provides a comprehensive summary of the most current marine biomaterial-based nano-/micro-systems developed over the past three years, primarily focusing on therapeutic delivery studies and highlighting their potential to cure a variety of diseases. Specifically, we first provided a detailed introduction to the physicochemical characteristics and biological activities of natural marine biocomponents in their raw state. Furthermore, the assembly processes, potential functionalities of each building block, and a thorough evaluation of the pharmacokinetics and pharmacodynamics of advanced marine biomaterial-based systems and their effects on molecular pathophysiological processes were fully elucidated. Finally, a list of unresolved issues and pivotal challenges of marine-derived biomaterials applications, such as standardized distinction of raw materials, long-term biosafety in vivo, the feasibility of scale-up, etc., was presented. This review is expected to serve as a roadmap for fundamental research and facilitate the rational design of marine biomaterials for diverse emerging applications. Graphical Abstract |
| first_indexed | 2024-03-11T11:01:12Z |
| format | Article |
| id | doaj.art-7ee93bf742fc4ce28893dee953c5749e |
| institution | Directory Open Access Journal |
| issn | 1477-3155 |
| language | English |
| last_indexed | 2024-03-11T11:01:12Z |
| publishDate | 2023-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Nanobiotechnology |
| spelling | doaj.art-7ee93bf742fc4ce28893dee953c5749e2023-11-12T12:29:13ZengBMCJournal of Nanobiotechnology1477-31552023-11-0121114810.1186/s12951-023-02112-wMarine biomaterials in biomedical nano/micro-systemsYanan Wang0Long Chen1Yuanzheng Wang2Xinyuan Wang3Deyao Qian4Jiahui Yan5Zeyu Sun6Pengfei Cui7Liangmin Yu8Jun Wu9Zhiyu He10Frontiers Science Center for Deep Ocean Multispheres and Earth Systems, Key Laboratory of Marine Chemistry Theory and Technology, Ministry of Education/Sanya Oceanographic Institution, Ocean University of ChinaDepartment of Orthopedics, Guizhou Provincial People’s HospitalDepartment of Orthopedics, Guizhou Provincial People’s HospitalFrontiers Science Center for Deep Ocean Multispheres and Earth Systems, Key Laboratory of Marine Chemistry Theory and Technology, Ministry of Education/Sanya Oceanographic Institution, Ocean University of ChinaFrontiers Science Center for Deep Ocean Multispheres and Earth Systems, Key Laboratory of Marine Chemistry Theory and Technology, Ministry of Education/Sanya Oceanographic Institution, Ocean University of ChinaFrontiers Science Center for Deep Ocean Multispheres and Earth Systems, Key Laboratory of Marine Chemistry Theory and Technology, Ministry of Education/Sanya Oceanographic Institution, Ocean University of ChinaDepartment of Orthopedics, Guizhou Provincial People’s HospitalCollege of Marine Life Sciences, Ocean University of ChinaFrontiers Science Center for Deep Ocean Multispheres and Earth Systems, Key Laboratory of Marine Chemistry Theory and Technology, Ministry of Education/Sanya Oceanographic Institution, Ocean University of ChinaDivision of Life Science, The Hong Kong University of Science and TechnologyFrontiers Science Center for Deep Ocean Multispheres and Earth Systems, Key Laboratory of Marine Chemistry Theory and Technology, Ministry of Education/Sanya Oceanographic Institution, Ocean University of ChinaAbstract Marine resources in unique marine environments provide abundant, cost-effective natural biomaterials with distinct structures, compositions, and biological activities compared to terrestrial species. These marine-derived raw materials, including polysaccharides, natural protein components, fatty acids, and marine minerals, etc., have shown great potential in preparing, stabilizing, or modifying multifunctional nano-/micro-systems and are widely applied in drug delivery, theragnostic, tissue engineering, etc. This review provides a comprehensive summary of the most current marine biomaterial-based nano-/micro-systems developed over the past three years, primarily focusing on therapeutic delivery studies and highlighting their potential to cure a variety of diseases. Specifically, we first provided a detailed introduction to the physicochemical characteristics and biological activities of natural marine biocomponents in their raw state. Furthermore, the assembly processes, potential functionalities of each building block, and a thorough evaluation of the pharmacokinetics and pharmacodynamics of advanced marine biomaterial-based systems and their effects on molecular pathophysiological processes were fully elucidated. Finally, a list of unresolved issues and pivotal challenges of marine-derived biomaterials applications, such as standardized distinction of raw materials, long-term biosafety in vivo, the feasibility of scale-up, etc., was presented. This review is expected to serve as a roadmap for fundamental research and facilitate the rational design of marine biomaterials for diverse emerging applications. Graphical Abstracthttps://doi.org/10.1186/s12951-023-02112-wChitosan-based nanoparticlesAlginate hydrogelsCollagen-based nanocomposites, marine fatty acid-based nanomaterialsMarine biomineralized nanocomposites |
| spellingShingle | Yanan Wang Long Chen Yuanzheng Wang Xinyuan Wang Deyao Qian Jiahui Yan Zeyu Sun Pengfei Cui Liangmin Yu Jun Wu Zhiyu He Marine biomaterials in biomedical nano/micro-systems Journal of Nanobiotechnology Chitosan-based nanoparticles Alginate hydrogels Collagen-based nanocomposites, marine fatty acid-based nanomaterials Marine biomineralized nanocomposites |
| title | Marine biomaterials in biomedical nano/micro-systems |
| title_full | Marine biomaterials in biomedical nano/micro-systems |
| title_fullStr | Marine biomaterials in biomedical nano/micro-systems |
| title_full_unstemmed | Marine biomaterials in biomedical nano/micro-systems |
| title_short | Marine biomaterials in biomedical nano/micro-systems |
| title_sort | marine biomaterials in biomedical nano micro systems |
| topic | Chitosan-based nanoparticles Alginate hydrogels Collagen-based nanocomposites, marine fatty acid-based nanomaterials Marine biomineralized nanocomposites |
| url | https://doi.org/10.1186/s12951-023-02112-w |
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