L-Arginine abrogates maternal and pre-pubertal codeine exposure-induced impaired spermatogenesis and sperm quality by modulating the levels of mRNA encoding spermatogenic genes

L-Arginine abrogates maternal and pre-pubertal codeine exposure-induced impaired spermatogenesis and sperm quality by modulating the levels of mRNA encoding spermatogenic genes

IntroductionAlthough, codeine has been demonstrated to lower sperm quality; the effects of maternal and prepubertal codeine exposure on male offspring is yet to be reported. In addition, the effect of arginine on codeine-induced decline in sperm quality has not been explored. This study investigated...

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Bibliographic Details
Main Authors: Roland Eghoghosoa Akhigbe, Oladele A. Afolabi, Ayodeji Folorusho Ajayi
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-07-01
Series:Frontiers in Endocrinology
Subjects:
arginine
codeine
developmental programming
endocrine disrupting chemicals
infertility
opioid
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2023.1180085/full

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