Trimethyl-Chitosan Coated Gold Nanoparticles Enhance Delivery, Cellular Uptake and Gene Silencing Effect of EGFR-siRNA in Breast Cancer Cells

Trimethyl-Chitosan Coated Gold Nanoparticles Enhance Delivery, Cellular Uptake and Gene Silencing Effect of EGFR-siRNA in Breast Cancer Cells

Purpose: Despite the promising therapeutic effects of gene silencing with small interfering RNAs (siRNAs), the challenges associated with delivery of siRNAs to the tumor cells in vivo, has greatly limited its clinical application. To overcome these challenges, we employed gold nanoparticles modified...

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Bibliographic Details
Main Authors: Leila Baghani, Niloofar Noroozi Heris, Fatemeh Khonsari, Sajad Dinarvand, Meshkat Dinarvand, Fatemeh Atyabi
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Molecular Biosciences
Subjects:
gold nanoparticles (AuNPs)
trimethyl chitosan (TMC)
EGFR-siRNA
siRNA delivery
breast cancer
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2022.871541/full

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