The Influence of Antibiotic Resistance on Innate Immune Responses to <i>Staphylococcus aureus</i> Infection
<i>Staphylococcus aureus</i> (<i>S. aureus</i>) causes a broad range of infections and is associated with significant morbidity and mortality. <i>S. aureus</i> produces a diverse range of cellular and extracellular factors responsible for its invasiveness and abil...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-04-01
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| Series: | Antibiotics |
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| Online Access: | https://www.mdpi.com/2079-6382/11/5/542 |
| _version_ | 1827670817039712256 |
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| author | Nazneen Jahan Timothy Patton Meredith O’Keeffe |
| author_facet | Nazneen Jahan Timothy Patton Meredith O’Keeffe |
| author_sort | Nazneen Jahan |
| collection | DOAJ |
| description | <i>Staphylococcus aureus</i> (<i>S. aureus</i>) causes a broad range of infections and is associated with significant morbidity and mortality. <i>S. aureus</i> produces a diverse range of cellular and extracellular factors responsible for its invasiveness and ability to resist immune attack. In recent years, increasing resistance to last-line anti-staphylococcal antibiotics daptomycin and vancomycin has been observed. Resistant strains of <i>S. aureus</i> are highly efficient in invading a variety of professional and nonprofessional phagocytes and are able to survive inside host cells. Eliciting immune protection against antibiotic-resistant <i>S. aureus</i> infection is a global challenge, requiring both innate and adaptive immune effector mechanisms. Dendritic cells (DC), which sit at the interface between innate and adaptive immune responses, are central to the induction of immune protection against <i>S. aureus</i>. However, it has been observed that <i>S. aureus</i> has the capacity to develop further antibiotic resistance and acquire increased resistance to immunological recognition by the innate immune system. In this article, we review the strategies utilised by <i>S. aureus</i> to circumvent antibiotic and innate immune responses, especially the interaction between <i>S. aureus</i> and DC, focusing on how this relationship is perturbed with the development of antibiotic resistance. |
| first_indexed | 2024-03-10T03:28:22Z |
| format | Article |
| id | doaj.art-7eee7247aa57436e834e8d811d5b5538 |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-10T03:28:22Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-7eee7247aa57436e834e8d811d5b55382023-11-23T09:47:30ZengMDPI AGAntibiotics2079-63822022-04-0111554210.3390/antibiotics11050542The Influence of Antibiotic Resistance on Innate Immune Responses to <i>Staphylococcus aureus</i> InfectionNazneen Jahan0Timothy Patton1Meredith O’Keeffe2Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, AustraliaDepartment of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, VIC 3000, AustraliaDepartment of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia<i>Staphylococcus aureus</i> (<i>S. aureus</i>) causes a broad range of infections and is associated with significant morbidity and mortality. <i>S. aureus</i> produces a diverse range of cellular and extracellular factors responsible for its invasiveness and ability to resist immune attack. In recent years, increasing resistance to last-line anti-staphylococcal antibiotics daptomycin and vancomycin has been observed. Resistant strains of <i>S. aureus</i> are highly efficient in invading a variety of professional and nonprofessional phagocytes and are able to survive inside host cells. Eliciting immune protection against antibiotic-resistant <i>S. aureus</i> infection is a global challenge, requiring both innate and adaptive immune effector mechanisms. Dendritic cells (DC), which sit at the interface between innate and adaptive immune responses, are central to the induction of immune protection against <i>S. aureus</i>. However, it has been observed that <i>S. aureus</i> has the capacity to develop further antibiotic resistance and acquire increased resistance to immunological recognition by the innate immune system. In this article, we review the strategies utilised by <i>S. aureus</i> to circumvent antibiotic and innate immune responses, especially the interaction between <i>S. aureus</i> and DC, focusing on how this relationship is perturbed with the development of antibiotic resistance.https://www.mdpi.com/2079-6382/11/5/542<i>Staphylococcus aureus</i>antibiotic resistanceinnate immunity |
| spellingShingle | Nazneen Jahan Timothy Patton Meredith O’Keeffe The Influence of Antibiotic Resistance on Innate Immune Responses to <i>Staphylococcus aureus</i> Infection Antibiotics <i>Staphylococcus aureus</i> antibiotic resistance innate immunity |
| title | The Influence of Antibiotic Resistance on Innate Immune Responses to <i>Staphylococcus aureus</i> Infection |
| title_full | The Influence of Antibiotic Resistance on Innate Immune Responses to <i>Staphylococcus aureus</i> Infection |
| title_fullStr | The Influence of Antibiotic Resistance on Innate Immune Responses to <i>Staphylococcus aureus</i> Infection |
| title_full_unstemmed | The Influence of Antibiotic Resistance on Innate Immune Responses to <i>Staphylococcus aureus</i> Infection |
| title_short | The Influence of Antibiotic Resistance on Innate Immune Responses to <i>Staphylococcus aureus</i> Infection |
| title_sort | influence of antibiotic resistance on innate immune responses to i staphylococcus aureus i infection |
| topic | <i>Staphylococcus aureus</i> antibiotic resistance innate immunity |
| url | https://www.mdpi.com/2079-6382/11/5/542 |
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