Systemic inflammation in 222.841 healthy employed smokers and nonsmokers: white blood cell count and relationship to spirometry
Background Smoking has been linked to low-grade systemic inflammation, a known risk factor for disease. This state is reflected in elevated white blood cell (WBC) count. Objective We analyzed the relationship between WBC count and smoking in healthy men and women across several age ranges who under...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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European Publishing
2012-05-01
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| Series: | Tobacco Induced Diseases |
| Subjects: | |
| Online Access: | http://www.journalssystem.com/tid/Systemic-inflammation-in-222-841-healthy-employed-smokers-and-nonsmokers-white-blood-cell-count-and-relationship-to-spirometry,66090,0,2.html |
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| author | José Antonio Fiz Fernández Josép Morera Prats José Vicente Monsonis Artero Alberto Calvo Mora Anna Vazquez Fariñas Anna Espinal José Antonio Gelpi Méndez |
| author_facet | José Antonio Fiz Fernández Josép Morera Prats José Vicente Monsonis Artero Alberto Calvo Mora Anna Vazquez Fariñas Anna Espinal José Antonio Gelpi Méndez |
| author_sort | José Antonio Fiz Fernández |
| collection | DOAJ |
| description | Background
Smoking has been linked to low-grade systemic inflammation, a known risk factor for disease. This
state is reflected in elevated white blood cell (WBC) count.
Objective
We analyzed the relationship between WBC count and smoking in healthy men and women across
several age ranges who underwent preventive medical check-ups in the workplace. We also analysed the
relationship between smoking and lung function
Methods
Cross-sectional descriptive study in 163 459 men and 59 382 women aged between 16 and 70 years.
Data analysed were smoking status, WBC count, and spirometry readings.
Results
Total WBC showed higher counts in both male and female smokers, around 1000 to 1300 cell/ml (t test,
P < 0.001). Forced expiratory volume in 1 second (FEV1%) was higher in nonsmokers for both sexes between 25 to
54 years (t test, P < 0.001). Analysis of covariance showed a multiple variable effect of age, sex, smoking status, body
mass index on WBC count. The relationship between WBC blood count and smoking status was confirmed after
the sample was stratified for these variables. Smokers with airway obstruction measured by FEV1% were found to
have higher WBC counts, in comparison to smokers with a normal FEV1% among similar age and BMI groups.
Conclusions
Smoking increases WBC count and affects lung function. The effects are evident across a wide age
range, underlining the importance of initiating preventive measures as soon as an individual begins to smoke. |
| first_indexed | 2024-04-13T16:23:03Z |
| format | Article |
| id | doaj.art-7eeed276bfa049a79eca2553ca3f16b7 |
| institution | Directory Open Access Journal |
| issn | 1617-9625 |
| language | English |
| last_indexed | 2024-04-13T16:23:03Z |
| publishDate | 2012-05-01 |
| publisher | European Publishing |
| record_format | Article |
| series | Tobacco Induced Diseases |
| spelling | doaj.art-7eeed276bfa049a79eca2553ca3f16b72022-12-22T02:39:51ZengEuropean PublishingTobacco Induced Diseases1617-96252012-05-0110May10.1186/1617-9625-10-766090Systemic inflammation in 222.841 healthy employed smokers and nonsmokers: white blood cell count and relationship to spirometryJosé Antonio Fiz Fernández0Josép Morera Prats1José Vicente Monsonis Artero2Alberto Calvo Mora3Anna Vazquez Fariñas4Anna Espinal5José Antonio Gelpi Méndez6Hospital Universitari Germans Trias i Pujol, Servicio de Neumología, Badalona, Barcelona, SpainHospital Universitari Germans Trias i Pujol, Servicio de Neumología, Badalona, Barcelona, SpainSociedad de Prevención de Ibermutuamur, Madrid, SpainSociedad de Prevención de Ibermutuamur, Madrid, SpainServei d’statística Aplicada, Universitat Autónoma de Barcelona, Barcelona, SpainServei d’statística Aplicada, Universitat Autónoma de Barcelona, Barcelona, SpainSociedad de Prevención de Ibermutuamur, Madrid, SpainBackground Smoking has been linked to low-grade systemic inflammation, a known risk factor for disease. This state is reflected in elevated white blood cell (WBC) count. Objective We analyzed the relationship between WBC count and smoking in healthy men and women across several age ranges who underwent preventive medical check-ups in the workplace. We also analysed the relationship between smoking and lung function Methods Cross-sectional descriptive study in 163 459 men and 59 382 women aged between 16 and 70 years. Data analysed were smoking status, WBC count, and spirometry readings. Results Total WBC showed higher counts in both male and female smokers, around 1000 to 1300 cell/ml (t test, P < 0.001). Forced expiratory volume in 1 second (FEV1%) was higher in nonsmokers for both sexes between 25 to 54 years (t test, P < 0.001). Analysis of covariance showed a multiple variable effect of age, sex, smoking status, body mass index on WBC count. The relationship between WBC blood count and smoking status was confirmed after the sample was stratified for these variables. Smokers with airway obstruction measured by FEV1% were found to have higher WBC counts, in comparison to smokers with a normal FEV1% among similar age and BMI groups. Conclusions Smoking increases WBC count and affects lung function. The effects are evident across a wide age range, underlining the importance of initiating preventive measures as soon as an individual begins to smoke.http://www.journalssystem.com/tid/Systemic-inflammation-in-222-841-healthy-employed-smokers-and-nonsmokers-white-blood-cell-count-and-relationship-to-spirometry,66090,0,2.htmlChronic Obstructive Pulmonary Diseasewhite blood cellwhite blood cell countairflow limitationmale smoker |
| spellingShingle | José Antonio Fiz Fernández Josép Morera Prats José Vicente Monsonis Artero Alberto Calvo Mora Anna Vazquez Fariñas Anna Espinal José Antonio Gelpi Méndez Systemic inflammation in 222.841 healthy employed smokers and nonsmokers: white blood cell count and relationship to spirometry Tobacco Induced Diseases Chronic Obstructive Pulmonary Disease white blood cell white blood cell count airflow limitation male smoker |
| title | Systemic inflammation in 222.841 healthy employed smokers and nonsmokers: white blood cell count and relationship to spirometry |
| title_full | Systemic inflammation in 222.841 healthy employed smokers and nonsmokers: white blood cell count and relationship to spirometry |
| title_fullStr | Systemic inflammation in 222.841 healthy employed smokers and nonsmokers: white blood cell count and relationship to spirometry |
| title_full_unstemmed | Systemic inflammation in 222.841 healthy employed smokers and nonsmokers: white blood cell count and relationship to spirometry |
| title_short | Systemic inflammation in 222.841 healthy employed smokers and nonsmokers: white blood cell count and relationship to spirometry |
| title_sort | systemic inflammation in 222 841 healthy employed smokers and nonsmokers white blood cell count and relationship to spirometry |
| topic | Chronic Obstructive Pulmonary Disease white blood cell white blood cell count airflow limitation male smoker |
| url | http://www.journalssystem.com/tid/Systemic-inflammation-in-222-841-healthy-employed-smokers-and-nonsmokers-white-blood-cell-count-and-relationship-to-spirometry,66090,0,2.html |
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