Effect of intraoperative dexmedetomidine on postoperative cognitive functions of elderly patients undergoing total laryngectomy
Abstract Background Postoperative cognitive dysfunction is commonly encountered after major surgical operations. This study was conducted to evaluate the effect of dexmedetomidine on neurocognitive dysfunction and postoperative recovery after total laryngectomy in the elderly population. Results Pre...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2022-06-01
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| Series: | Ain Shams Journal of Anesthesiology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s42077-022-00245-y |
| _version_ | 1818469618710216704 |
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| author | Ahmed Mohamed El-Shamy Amgad Abdel Mageed Zaghlol Mai Mahmoud Abdel Ghafar Shimaa Rabea Abdel Qader Hendawy Gehan Abd Allah Tarabeah |
| author_facet | Ahmed Mohamed El-Shamy Amgad Abdel Mageed Zaghlol Mai Mahmoud Abdel Ghafar Shimaa Rabea Abdel Qader Hendawy Gehan Abd Allah Tarabeah |
| author_sort | Ahmed Mohamed El-Shamy |
| collection | DOAJ |
| description | Abstract Background Postoperative cognitive dysfunction is commonly encountered after major surgical operations. This study was conducted to evaluate the effect of dexmedetomidine on neurocognitive dysfunction and postoperative recovery after total laryngectomy in the elderly population. Results Preoperative characteristics were comparable between the two groups. However, both sevoflurane consumption and recovery time were significantly decreased in the Dex group. Also, the time to first analgesic request and sedation level showed a significant improvement in the same group. The Dex group showed its superiority regarding most of the used cognitive tests. Although there was no significant difference between the two study groups regarding basal S100B, postoperative levels significantly decreased in the Dex group. Conclusions Dexmedetomidine administration is associated with a significant improvement of cognitive function after surgery in the elderly population. It is associated with a better analgesic and sedative profile along with decreased neurological inflammatory markers. However, the patient must be closely monitored for side effects like bradycardia and hypotension. |
| first_indexed | 2024-04-13T21:27:09Z |
| format | Article |
| id | doaj.art-7eef790f0525488c8dc970240c9a02a9 |
| institution | Directory Open Access Journal |
| issn | 2090-925X |
| language | English |
| last_indexed | 2024-04-13T21:27:09Z |
| publishDate | 2022-06-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Ain Shams Journal of Anesthesiology |
| spelling | doaj.art-7eef790f0525488c8dc970240c9a02a92022-12-22T02:29:18ZengSpringerOpenAin Shams Journal of Anesthesiology2090-925X2022-06-0114111010.1186/s42077-022-00245-yEffect of intraoperative dexmedetomidine on postoperative cognitive functions of elderly patients undergoing total laryngectomyAhmed Mohamed El-Shamy0Amgad Abdel Mageed Zaghlol1Mai Mahmoud Abdel Ghafar2Shimaa Rabea Abdel Qader Hendawy3Gehan Abd Allah Tarabeah4Anesthesia and Surgical Intensive Care, Faculty of Medicine, Mansoura UniversityAnesthesia and Surgical Intensive Care, Faculty of Medicine, Mansoura UniversityAnesthesia and Surgical Intensive Care, Faculty of Medicine, Mansoura UniversityClinical Pathology, Faculty of Medicine, Mansoura UniversityAnesthesia and Surgical Intensive Care, Faculty of Medicine, Mansoura UniversityAbstract Background Postoperative cognitive dysfunction is commonly encountered after major surgical operations. This study was conducted to evaluate the effect of dexmedetomidine on neurocognitive dysfunction and postoperative recovery after total laryngectomy in the elderly population. Results Preoperative characteristics were comparable between the two groups. However, both sevoflurane consumption and recovery time were significantly decreased in the Dex group. Also, the time to first analgesic request and sedation level showed a significant improvement in the same group. The Dex group showed its superiority regarding most of the used cognitive tests. Although there was no significant difference between the two study groups regarding basal S100B, postoperative levels significantly decreased in the Dex group. Conclusions Dexmedetomidine administration is associated with a significant improvement of cognitive function after surgery in the elderly population. It is associated with a better analgesic and sedative profile along with decreased neurological inflammatory markers. However, the patient must be closely monitored for side effects like bradycardia and hypotension.https://doi.org/10.1186/s42077-022-00245-yDexmedetomidinePost-operative cognitive dysfunctionSedationPain |
| spellingShingle | Ahmed Mohamed El-Shamy Amgad Abdel Mageed Zaghlol Mai Mahmoud Abdel Ghafar Shimaa Rabea Abdel Qader Hendawy Gehan Abd Allah Tarabeah Effect of intraoperative dexmedetomidine on postoperative cognitive functions of elderly patients undergoing total laryngectomy Ain Shams Journal of Anesthesiology Dexmedetomidine Post-operative cognitive dysfunction Sedation Pain |
| title | Effect of intraoperative dexmedetomidine on postoperative cognitive functions of elderly patients undergoing total laryngectomy |
| title_full | Effect of intraoperative dexmedetomidine on postoperative cognitive functions of elderly patients undergoing total laryngectomy |
| title_fullStr | Effect of intraoperative dexmedetomidine on postoperative cognitive functions of elderly patients undergoing total laryngectomy |
| title_full_unstemmed | Effect of intraoperative dexmedetomidine on postoperative cognitive functions of elderly patients undergoing total laryngectomy |
| title_short | Effect of intraoperative dexmedetomidine on postoperative cognitive functions of elderly patients undergoing total laryngectomy |
| title_sort | effect of intraoperative dexmedetomidine on postoperative cognitive functions of elderly patients undergoing total laryngectomy |
| topic | Dexmedetomidine Post-operative cognitive dysfunction Sedation Pain |
| url | https://doi.org/10.1186/s42077-022-00245-y |
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