Blending Ethnomedicine with Modern Technology—From Conventional to Tailored Products: Modulating Biopharmaceutical Properties of <i>Berberis</i> Extract by Solid Lipid Nanoparticles for Wound Healing
Drug-delivery systems employing phytopharmaceuticals based on the leads in traditional knowledge offers not only an alternative but quicker and more economic strategy for drug development. Nanophytopharmaceuticals promise remarkable opportunities with the ability to overcome challenges associated wi...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-08-01
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| Series: | Journal of Functional Biomaterials |
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| Online Access: | https://www.mdpi.com/2079-4983/14/8/418 |
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| author | Neetika Sharma Karan Vasisht Jasmine Kaur Simarjot Kaur Sandhu Kaustav Dey Bakr Ahmed Hameed Rakesh Bajaj Indu Pal Kaur Maninder Karan |
| author_facet | Neetika Sharma Karan Vasisht Jasmine Kaur Simarjot Kaur Sandhu Kaustav Dey Bakr Ahmed Hameed Rakesh Bajaj Indu Pal Kaur Maninder Karan |
| author_sort | Neetika Sharma |
| collection | DOAJ |
| description | Drug-delivery systems employing phytopharmaceuticals based on the leads in traditional knowledge offers not only an alternative but quicker and more economic strategy for drug development. Nanophytopharmaceuticals promise remarkable opportunities with the ability to overcome challenges associated with herbal medicines, such as low solubility and bioavailability, poor target specificity, and shelf life. <i>Berberis</i> extracts documented as Ropana (wound healer) in <i>Sushruta Samhita</i> are a popular traditional remedy that is amiss in the modern system of medicine as it exhibits very poor biopharmaceutical properties. Poor solubility and bioavailability necessitate the administration of high doses to achieve the desired therapeutic effects. Exploiting the diversified type of compounds with pleiotropic properties present in <i>Berberis</i>, the biopharmaceutical properties were engineered using an optimized freeze-dried extract and developed solid lipid nanoparticles (SLNs) as an effective drug-delivery system. An industrially viable and environment-friendly hot high-pressure homogenization technique led to a stable formulation with an average particle size of 178.4 nm, as well as a 7-fold increase in loading and a significant entrapment of 91 ± 1.25%. The pharmacodynamic studies of developed nanosystems in excision-wound models showed faster and complete healing of wounds with no scars. |
| first_indexed | 2024-03-10T23:50:34Z |
| format | Article |
| id | doaj.art-7ef2abe3caf1496b964a641bb3112f23 |
| institution | Directory Open Access Journal |
| issn | 2079-4983 |
| language | English |
| last_indexed | 2024-03-10T23:50:34Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Functional Biomaterials |
| spelling | doaj.art-7ef2abe3caf1496b964a641bb3112f232023-11-19T01:43:14ZengMDPI AGJournal of Functional Biomaterials2079-49832023-08-0114841810.3390/jfb14080418Blending Ethnomedicine with Modern Technology—From Conventional to Tailored Products: Modulating Biopharmaceutical Properties of <i>Berberis</i> Extract by Solid Lipid Nanoparticles for Wound HealingNeetika Sharma0Karan Vasisht1Jasmine Kaur2Simarjot Kaur Sandhu3Kaustav Dey4Bakr Ahmed Hameed5Rakesh Bajaj6Indu Pal Kaur7Maninder Karan8University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh 160014, IndiaUniversity Institute of Pharmaceutical Sciences, Panjab University, Chandigarh 160014, IndiaUniversity Institute of Pharmaceutical Sciences, Panjab University, Chandigarh 160014, IndiaUniversity Institute of Pharmaceutical Sciences, Panjab University, Chandigarh 160014, IndiaUniversity Institute of Pharmaceutical Sciences, Panjab University, Chandigarh 160014, IndiaUniversity Institute of Pharmaceutical Sciences, Panjab University, Chandigarh 160014, IndiaNanz Med Science Pharma (P) Ltd., Paonta Sahib 173025, IndiaUniversity Institute of Pharmaceutical Sciences, Panjab University, Chandigarh 160014, IndiaUniversity Institute of Pharmaceutical Sciences, Panjab University, Chandigarh 160014, IndiaDrug-delivery systems employing phytopharmaceuticals based on the leads in traditional knowledge offers not only an alternative but quicker and more economic strategy for drug development. Nanophytopharmaceuticals promise remarkable opportunities with the ability to overcome challenges associated with herbal medicines, such as low solubility and bioavailability, poor target specificity, and shelf life. <i>Berberis</i> extracts documented as Ropana (wound healer) in <i>Sushruta Samhita</i> are a popular traditional remedy that is amiss in the modern system of medicine as it exhibits very poor biopharmaceutical properties. Poor solubility and bioavailability necessitate the administration of high doses to achieve the desired therapeutic effects. Exploiting the diversified type of compounds with pleiotropic properties present in <i>Berberis</i>, the biopharmaceutical properties were engineered using an optimized freeze-dried extract and developed solid lipid nanoparticles (SLNs) as an effective drug-delivery system. An industrially viable and environment-friendly hot high-pressure homogenization technique led to a stable formulation with an average particle size of 178.4 nm, as well as a 7-fold increase in loading and a significant entrapment of 91 ± 1.25%. The pharmacodynamic studies of developed nanosystems in excision-wound models showed faster and complete healing of wounds with no scars.https://www.mdpi.com/2079-4983/14/8/418herbalnatural extractdrug deliverysolubilitystabilityexcision wound |
| spellingShingle | Neetika Sharma Karan Vasisht Jasmine Kaur Simarjot Kaur Sandhu Kaustav Dey Bakr Ahmed Hameed Rakesh Bajaj Indu Pal Kaur Maninder Karan Blending Ethnomedicine with Modern Technology—From Conventional to Tailored Products: Modulating Biopharmaceutical Properties of <i>Berberis</i> Extract by Solid Lipid Nanoparticles for Wound Healing Journal of Functional Biomaterials herbal natural extract drug delivery solubility stability excision wound |
| title | Blending Ethnomedicine with Modern Technology—From Conventional to Tailored Products: Modulating Biopharmaceutical Properties of <i>Berberis</i> Extract by Solid Lipid Nanoparticles for Wound Healing |
| title_full | Blending Ethnomedicine with Modern Technology—From Conventional to Tailored Products: Modulating Biopharmaceutical Properties of <i>Berberis</i> Extract by Solid Lipid Nanoparticles for Wound Healing |
| title_fullStr | Blending Ethnomedicine with Modern Technology—From Conventional to Tailored Products: Modulating Biopharmaceutical Properties of <i>Berberis</i> Extract by Solid Lipid Nanoparticles for Wound Healing |
| title_full_unstemmed | Blending Ethnomedicine with Modern Technology—From Conventional to Tailored Products: Modulating Biopharmaceutical Properties of <i>Berberis</i> Extract by Solid Lipid Nanoparticles for Wound Healing |
| title_short | Blending Ethnomedicine with Modern Technology—From Conventional to Tailored Products: Modulating Biopharmaceutical Properties of <i>Berberis</i> Extract by Solid Lipid Nanoparticles for Wound Healing |
| title_sort | blending ethnomedicine with modern technology from conventional to tailored products modulating biopharmaceutical properties of i berberis i extract by solid lipid nanoparticles for wound healing |
| topic | herbal natural extract drug delivery solubility stability excision wound |
| url | https://www.mdpi.com/2079-4983/14/8/418 |
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