A Novel NIR Fluorescent Nanoprobe Targeting HER2-Positive Breast Cancer: Tra-TTR-A

TTRE, a photosensitizer molecule, has excellent biofluorescence imaging performance and effective antitumor properties for breast cancer. However, its application in breast cancer treatment is limited due to poor tumor selectivity and lack of targeting ability. In this study, TTRE and trastuzumab we...

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Main Authors: Meijuan Chen, Zhousheng Lin, Guangyu Yao, Xi Hong, Xiaolei Xue, Lujia Chen
Format: Article
Language:English
Published: Hindawi Limited 2021-01-01
Series:Bioinorganic Chemistry and Applications
Online Access:http://dx.doi.org/10.1155/2021/2495958
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author Meijuan Chen
Zhousheng Lin
Guangyu Yao
Xi Hong
Xiaolei Xue
Lujia Chen
author_facet Meijuan Chen
Zhousheng Lin
Guangyu Yao
Xi Hong
Xiaolei Xue
Lujia Chen
author_sort Meijuan Chen
collection DOAJ
description TTRE, a photosensitizer molecule, has excellent biofluorescence imaging performance and effective antitumor properties for breast cancer. However, its application in breast cancer treatment is limited due to poor tumor selectivity and lack of targeting ability. In this study, TTRE and trastuzumab were combined to synthesize Tra-TTR-A, a novel near-infrared fluorescent nanoprobe for HER2 positive breast cancer. The targeting and antitumor abilities of Tra-TTR-A in breast cancer were also investigated. Like TTRE, Tra-TTR-A has a stable structure with remarkable optical properties and in vivo imaging capacity. However, Tra-TTR-A not only inhibits tumor growth by generating reactive oxygen species but also kills tumor cells by trastuzumab. In this study, Tra-TTR-A, a new type of near-infrared fluorescent nanoprobe that targets HER2-positive breast cancer, was successfully synthesized. Tra-TTR-A could be used in in vivo imaging, targeted photodynamic therapy, and diagnosis and treatment for breast cancer.
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spelling doaj.art-7ef2f4947bdc4b13b4a765ef21be72b42022-12-22T04:04:11ZengHindawi LimitedBioinorganic Chemistry and Applications1687-479X2021-01-01202110.1155/2021/2495958A Novel NIR Fluorescent Nanoprobe Targeting HER2-Positive Breast Cancer: Tra-TTR-AMeijuan Chen0Zhousheng Lin1Guangyu Yao2Xi Hong3Xiaolei Xue4Lujia Chen5State Key Laboratory of Organ Failure ResearchBreast CenterBreast CenterBreast CenterDepartment of PathologyBreast CenterTTRE, a photosensitizer molecule, has excellent biofluorescence imaging performance and effective antitumor properties for breast cancer. However, its application in breast cancer treatment is limited due to poor tumor selectivity and lack of targeting ability. In this study, TTRE and trastuzumab were combined to synthesize Tra-TTR-A, a novel near-infrared fluorescent nanoprobe for HER2 positive breast cancer. The targeting and antitumor abilities of Tra-TTR-A in breast cancer were also investigated. Like TTRE, Tra-TTR-A has a stable structure with remarkable optical properties and in vivo imaging capacity. However, Tra-TTR-A not only inhibits tumor growth by generating reactive oxygen species but also kills tumor cells by trastuzumab. In this study, Tra-TTR-A, a new type of near-infrared fluorescent nanoprobe that targets HER2-positive breast cancer, was successfully synthesized. Tra-TTR-A could be used in in vivo imaging, targeted photodynamic therapy, and diagnosis and treatment for breast cancer.http://dx.doi.org/10.1155/2021/2495958
spellingShingle Meijuan Chen
Zhousheng Lin
Guangyu Yao
Xi Hong
Xiaolei Xue
Lujia Chen
A Novel NIR Fluorescent Nanoprobe Targeting HER2-Positive Breast Cancer: Tra-TTR-A
Bioinorganic Chemistry and Applications
title A Novel NIR Fluorescent Nanoprobe Targeting HER2-Positive Breast Cancer: Tra-TTR-A
title_full A Novel NIR Fluorescent Nanoprobe Targeting HER2-Positive Breast Cancer: Tra-TTR-A
title_fullStr A Novel NIR Fluorescent Nanoprobe Targeting HER2-Positive Breast Cancer: Tra-TTR-A
title_full_unstemmed A Novel NIR Fluorescent Nanoprobe Targeting HER2-Positive Breast Cancer: Tra-TTR-A
title_short A Novel NIR Fluorescent Nanoprobe Targeting HER2-Positive Breast Cancer: Tra-TTR-A
title_sort novel nir fluorescent nanoprobe targeting her2 positive breast cancer tra ttr a
url http://dx.doi.org/10.1155/2021/2495958
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