Prevalence and characteristics of apparent treatment-resistant hypertension in older people in China: a cross-sectional study
The prevalence and associated risk factors of apparent treatment-resistant hypertension (aTRH) in older people in China is unknown. The aim of this study is to investigate the prevalence of aTRH in older people and describe the characteristics of older patients with aTRH. Using two-stage random clus...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2019-11-01
|
| Series: | Clinical and Experimental Hypertension |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/10641963.2018.1545852 |
| _version_ | 1827814261158576128 |
|---|---|
| author | Cunjin Wu Yibo Wang Weili Zhang Xin Li Lin Wang Rutai Hui |
| author_facet | Cunjin Wu Yibo Wang Weili Zhang Xin Li Lin Wang Rutai Hui |
| author_sort | Cunjin Wu |
| collection | DOAJ |
| description | The prevalence and associated risk factors of apparent treatment-resistant hypertension (aTRH) in older people in China is unknown. The aim of this study is to investigate the prevalence of aTRH in older people and describe the characteristics of older patients with aTRH. Using two-stage random clustering sampling, 3774 patients with hypertension aged ≥60–75 years were recruited between July 2012 and December 2015. The patients were divided into two groups: aTRH and non-aTRH groups according to their blood pressure (BP) levels, and whether or not they reached goal BP value. A multivariable logistical model was used to evaluate the risk factors of aTRH. The rate of antihypertensive treatment was 75.1%, BP control rate was 40.7%, and the prevalence of aTRH was 5.97% (169) according to the cross-sectional data among all the patients. The prevalence of aTRH patients taking 4 different classes of antihypertensive drugs or more was found to be 3.29% (93) in this study. Compared with non-aTRH patients, those with aTRH had a worse cardiovascular risk profile, including obesity (29.61% vs 20.53%, P = 0.005), hyperlipidemia (54.44% vs 46.66%, P = 0.050), type 2 diabetes mellitus (2-DM) (34.31% vs 25.64%, P = 0.013), and stroke (26.03% vs 19.26%, P = 0.032). After multivariable adjustment, logistic regression analyses showed that the risk factors of aTRH were male sex (OR 1.638; 95%CI 1.196–2.245, P = 0.002) and 2-DM (OR 1. 371; 95%CI 0.995–1.888, P = 0.049). Regular physical exercise (OR 0.696; 95%CI 0.505–0.960, P = 0.049) was a protective factor of aTRH. The prevalence of aTRH was 5.97% in older people in this cross-sectional study in China. |
| first_indexed | 2024-03-11T23:43:02Z |
| format | Article |
| id | doaj.art-7ef4157cc1ac458d8406fb0c133b9d36 |
| institution | Directory Open Access Journal |
| issn | 1064-1963 1525-6006 |
| language | English |
| last_indexed | 2024-03-11T23:43:02Z |
| publishDate | 2019-11-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Clinical and Experimental Hypertension |
| spelling | doaj.art-7ef4157cc1ac458d8406fb0c133b9d362023-09-19T15:19:28ZengTaylor & Francis GroupClinical and Experimental Hypertension1064-19631525-60062019-11-0141875375810.1080/10641963.2018.15458521545852Prevalence and characteristics of apparent treatment-resistant hypertension in older people in China: a cross-sectional studyCunjin Wu0Yibo Wang1Weili Zhang2Xin Li3Lin Wang4Rutai Hui5Chinese Academy of Medical Sciences and Peking Union Medical CollegeChinese Academy of Medical Sciences and Peking Union Medical CollegeChinese Academy of Medical Sciences and Peking Union Medical CollegeSecond Hospital of Tianjin Medical UniversitySecond Hospital of Tianjin Medical UniversityChinese Academy of Medical Sciences and Peking Union Medical CollegeThe prevalence and associated risk factors of apparent treatment-resistant hypertension (aTRH) in older people in China is unknown. The aim of this study is to investigate the prevalence of aTRH in older people and describe the characteristics of older patients with aTRH. Using two-stage random clustering sampling, 3774 patients with hypertension aged ≥60–75 years were recruited between July 2012 and December 2015. The patients were divided into two groups: aTRH and non-aTRH groups according to their blood pressure (BP) levels, and whether or not they reached goal BP value. A multivariable logistical model was used to evaluate the risk factors of aTRH. The rate of antihypertensive treatment was 75.1%, BP control rate was 40.7%, and the prevalence of aTRH was 5.97% (169) according to the cross-sectional data among all the patients. The prevalence of aTRH patients taking 4 different classes of antihypertensive drugs or more was found to be 3.29% (93) in this study. Compared with non-aTRH patients, those with aTRH had a worse cardiovascular risk profile, including obesity (29.61% vs 20.53%, P = 0.005), hyperlipidemia (54.44% vs 46.66%, P = 0.050), type 2 diabetes mellitus (2-DM) (34.31% vs 25.64%, P = 0.013), and stroke (26.03% vs 19.26%, P = 0.032). After multivariable adjustment, logistic regression analyses showed that the risk factors of aTRH were male sex (OR 1.638; 95%CI 1.196–2.245, P = 0.002) and 2-DM (OR 1. 371; 95%CI 0.995–1.888, P = 0.049). Regular physical exercise (OR 0.696; 95%CI 0.505–0.960, P = 0.049) was a protective factor of aTRH. The prevalence of aTRH was 5.97% in older people in this cross-sectional study in China.http://dx.doi.org/10.1080/10641963.2018.1545852resistant hypertensionprevalencerisk factorolder people |
| spellingShingle | Cunjin Wu Yibo Wang Weili Zhang Xin Li Lin Wang Rutai Hui Prevalence and characteristics of apparent treatment-resistant hypertension in older people in China: a cross-sectional study Clinical and Experimental Hypertension resistant hypertension prevalence risk factor older people |
| title | Prevalence and characteristics of apparent treatment-resistant hypertension in older people in China: a cross-sectional study |
| title_full | Prevalence and characteristics of apparent treatment-resistant hypertension in older people in China: a cross-sectional study |
| title_fullStr | Prevalence and characteristics of apparent treatment-resistant hypertension in older people in China: a cross-sectional study |
| title_full_unstemmed | Prevalence and characteristics of apparent treatment-resistant hypertension in older people in China: a cross-sectional study |
| title_short | Prevalence and characteristics of apparent treatment-resistant hypertension in older people in China: a cross-sectional study |
| title_sort | prevalence and characteristics of apparent treatment resistant hypertension in older people in china a cross sectional study |
| topic | resistant hypertension prevalence risk factor older people |
| url | http://dx.doi.org/10.1080/10641963.2018.1545852 |
| work_keys_str_mv | AT cunjinwu prevalenceandcharacteristicsofapparenttreatmentresistanthypertensioninolderpeopleinchinaacrosssectionalstudy AT yibowang prevalenceandcharacteristicsofapparenttreatmentresistanthypertensioninolderpeopleinchinaacrosssectionalstudy AT weilizhang prevalenceandcharacteristicsofapparenttreatmentresistanthypertensioninolderpeopleinchinaacrosssectionalstudy AT xinli prevalenceandcharacteristicsofapparenttreatmentresistanthypertensioninolderpeopleinchinaacrosssectionalstudy AT linwang prevalenceandcharacteristicsofapparenttreatmentresistanthypertensioninolderpeopleinchinaacrosssectionalstudy AT rutaihui prevalenceandcharacteristicsofapparenttreatmentresistanthypertensioninolderpeopleinchinaacrosssectionalstudy |