Distribution and Excretion of Arsenic Metabolites after Oral Administration of Seafood-Related Organoarsenicals in Rats
Less information is available on the metabolism of organic arsenicals compared to inorganic arsenic in mammals. In the present study, we investigated tissue distribution, metabolism and excretion in rats of organoarsenicals, dimethylarsinic acid (DMAV), arsenobetaine (AB), arsenocholine (AC) and tri...
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MDPI AG
2016-09-01
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| Series: | Metals |
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| Online Access: | http://www.mdpi.com/2075-4701/6/10/231 |
| _version_ | 1818929727642009600 |
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| author | Yayoi Kobayashi Seishiro Hirano |
| author_facet | Yayoi Kobayashi Seishiro Hirano |
| author_sort | Yayoi Kobayashi |
| collection | DOAJ |
| description | Less information is available on the metabolism of organic arsenicals compared to inorganic arsenic in mammals. In the present study, we investigated tissue distribution, metabolism and excretion in rats of organoarsenicals, dimethylarsinic acid (DMAV), arsenobetaine (AB), arsenocholine (AC) and trimethylarsine oxide (TMAOV). Among these animals, arsenic concentrations in red blood cells (RBCs) and spleen increased remarkably only in the DMAV group. Hepatic arsenic concentration increased significantly only in the AC group. Approximately 17%, 72% and 60% of the dose was excreted in urine in two days in the DMAV, AB and AC groups, respectively; virtually the entire dose was excreted in urine in one day in the TMAOV group. On the other hand, approximately 18%, 0.2%, 0.5% and 0.1% of the dose was excreted in feces in two days in the DMAV, AB, AC and TMAOV groups, respectively. A large amount of arsenic was accumulated in RBCs in the form of protein-bound dimethylarsinous acid (DMAIII), and dimethylmonothioarsinic acid (DMMTAV), a reportedly toxic thio-arsenical, was found in urine and fecal extract in the DMAV group. These results suggest that intake of DMAV is a potential health hazard, given that the metabolites of DMAV, such as DMAIII and DMMTAV, are known to be highly toxic. |
| first_indexed | 2024-12-20T03:49:24Z |
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| institution | Directory Open Access Journal |
| issn | 2075-4701 |
| language | English |
| last_indexed | 2024-12-20T03:49:24Z |
| publishDate | 2016-09-01 |
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| spelling | doaj.art-7ef5d61bb6154772980ab65bb8794cb12022-12-21T19:54:30ZengMDPI AGMetals2075-47012016-09-0161023110.3390/met6100231met6100231Distribution and Excretion of Arsenic Metabolites after Oral Administration of Seafood-Related Organoarsenicals in RatsYayoi Kobayashi0Seishiro Hirano1Centre for Health and Environmental Risk Research, National Institute for Environmental Studies, 16-2 Onogawa, Tsukuba, Ibaraki 305-8506, JapanCentre for Health and Environmental Risk Research, National Institute for Environmental Studies, 16-2 Onogawa, Tsukuba, Ibaraki 305-8506, JapanLess information is available on the metabolism of organic arsenicals compared to inorganic arsenic in mammals. In the present study, we investigated tissue distribution, metabolism and excretion in rats of organoarsenicals, dimethylarsinic acid (DMAV), arsenobetaine (AB), arsenocholine (AC) and trimethylarsine oxide (TMAOV). Among these animals, arsenic concentrations in red blood cells (RBCs) and spleen increased remarkably only in the DMAV group. Hepatic arsenic concentration increased significantly only in the AC group. Approximately 17%, 72% and 60% of the dose was excreted in urine in two days in the DMAV, AB and AC groups, respectively; virtually the entire dose was excreted in urine in one day in the TMAOV group. On the other hand, approximately 18%, 0.2%, 0.5% and 0.1% of the dose was excreted in feces in two days in the DMAV, AB, AC and TMAOV groups, respectively. A large amount of arsenic was accumulated in RBCs in the form of protein-bound dimethylarsinous acid (DMAIII), and dimethylmonothioarsinic acid (DMMTAV), a reportedly toxic thio-arsenical, was found in urine and fecal extract in the DMAV group. These results suggest that intake of DMAV is a potential health hazard, given that the metabolites of DMAV, such as DMAIII and DMMTAV, are known to be highly toxic.http://www.mdpi.com/2075-4701/6/10/231arsenicorganoarsenicalsdistributionmetabolismexcretionHPLC-ICP-MS |
| spellingShingle | Yayoi Kobayashi Seishiro Hirano Distribution and Excretion of Arsenic Metabolites after Oral Administration of Seafood-Related Organoarsenicals in Rats Metals arsenic organoarsenicals distribution metabolism excretion HPLC-ICP-MS |
| title | Distribution and Excretion of Arsenic Metabolites after Oral Administration of Seafood-Related Organoarsenicals in Rats |
| title_full | Distribution and Excretion of Arsenic Metabolites after Oral Administration of Seafood-Related Organoarsenicals in Rats |
| title_fullStr | Distribution and Excretion of Arsenic Metabolites after Oral Administration of Seafood-Related Organoarsenicals in Rats |
| title_full_unstemmed | Distribution and Excretion of Arsenic Metabolites after Oral Administration of Seafood-Related Organoarsenicals in Rats |
| title_short | Distribution and Excretion of Arsenic Metabolites after Oral Administration of Seafood-Related Organoarsenicals in Rats |
| title_sort | distribution and excretion of arsenic metabolites after oral administration of seafood related organoarsenicals in rats |
| topic | arsenic organoarsenicals distribution metabolism excretion HPLC-ICP-MS |
| url | http://www.mdpi.com/2075-4701/6/10/231 |
| work_keys_str_mv | AT yayoikobayashi distributionandexcretionofarsenicmetabolitesafteroraladministrationofseafoodrelatedorganoarsenicalsinrats AT seishirohirano distributionandexcretionofarsenicmetabolitesafteroraladministrationofseafoodrelatedorganoarsenicalsinrats |