Exogenous leptin enhances markers of airway fibrosis in a mouse model of chronic allergic airways disease

Exogenous leptin enhances markers of airway fibrosis in a mouse model of chronic allergic airways disease

Abstract Background Asthma patients with comorbid obesity exhibit increased disease severity, in part, due to airway remodeling, which is also observed in mouse models of asthma and obesity. A mediator of remodeling that is increased in obesity is leptin. We hypothesized that in a mouse model of all...

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Bibliographic Details
Main Authors: Mark D. Ihrie, Victoria L. McQuade, Jack T. Womble, Akhil Hegde, Matthew S. McCravy, Cyrus Victor G. Lacuesta, Robert M. Tighe, Loretta G. Que, Julia K. L. Walker, Jennifer L. Ingram
Format: Article
Language:English
Published: BMC 2022-05-01
Series:Respiratory Research
Subjects:
Leptin
Asthma
Airway remodeling
Sex differences
Online Access:https://doi.org/10.1186/s12931-022-02048-z

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