Hepatoprotective Effect of Acetylated Amino Acid on Methimazole Induced Hepatotoxicity in Mice
Objective: To explore the hepatoprotective effect of N‐acetylcysteine on methimazole induced hepatic damage in mice. Study Design: Randomized control trial. Place and Duration of Study: The study was carried out from Nov 2014 to Oct 2015 at the animal house of Army Medical College, Rawalpindi. Mater...
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| Format: | Article |
| Language: | English |
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Riphah International University, Islamabad
2016-12-01
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| Series: | Journal of Islamic International Medical College |
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| Online Access: | https://journals.riphah.edu.pk/index.php/jiimc/article/view/963 |
| Summary: | Objective: To explore the hepatoprotective effect of N‐acetylcysteine on methimazole induced hepatic damage in mice.
Study Design: Randomized control trial.
Place and Duration of Study: The study was carried out from Nov 2014 to Oct 2015 at the animal house of Army Medical College, Rawalpindi.
Materials and Methods: Thirty male BALB/c mice were randomly divided into three groups of ten animals each. Group I: Control group (C), Group II: Methimazole treated group (M), Group III: Pretreated N‐acetylcysteine (NAC) group. Single dose of Methimazole (MMI) (1000mg/kg, i.p) was injected for induction of hepatotoxicity. N‐acetylcysteine (NAC) (300mg/kg, i.p) was given pre Methimazole (MMI) administration. The extent of hepatic injury was determined by evaluation of serum alanine transaminase (ALT) and alkaline phosphatase (ALP) along with liver histopathology.
Results: Methimazole (MMI) produced liver damage as evident by markedly raised liver enzymes along with necrosis and inflammatory cell infiltration. N‐acetylcysteine (NAC) treated group resulted in reduction in elevation of serum biomarkers and improvement of histological picture.
Conclusion: N‐acetylcysteine (NAC) holds significant hepatoprotective effect against Methimazole (MMI) induced hepatotoxicity. |
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| ISSN: | 1815-4018 2410-5422 |