The Role of STAMP2 in Pathogenesis of Chronic Diseases Focusing on Nonalcoholic Fatty Liver Disease: A Review
Nonalcoholic fatty liver disease (NAFLD) is a major health issue. NAFLD can progress from simple hepatic steatosis to nonalcoholic steatohepatitis (NASH). NASH can progress to cirrhosis or hepatocellular carcinoma. Unfortunately, there is no currently approved pharmacologic therapy for NAFLD patient...
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| Format: | Article |
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MDPI AG
2022-08-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/10/9/2082 |
| _version_ | 1797490950450184192 |
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| author | Hye Young Kim Young Hyun Yoo |
| author_facet | Hye Young Kim Young Hyun Yoo |
| author_sort | Hye Young Kim |
| collection | DOAJ |
| description | Nonalcoholic fatty liver disease (NAFLD) is a major health issue. NAFLD can progress from simple hepatic steatosis to nonalcoholic steatohepatitis (NASH). NASH can progress to cirrhosis or hepatocellular carcinoma. Unfortunately, there is no currently approved pharmacologic therapy for NAFLD patients. The six transmembrane protein of prostate 2 (STAMP2), a metalloreductase involved in iron and copper homeostasis, is well known for its critical role in the coordination of glucose/lipid metabolism and inflammation in metabolic tissues. We previously demonstrated that hepatic STAMP2 could be a suitable therapeutic target for NAFLD. In this review, we discuss the emerging role of STAMP2 in the dysregulation of iron metabolism events leading to NAFLD and suggest therapeutic strategies targeting STAMP2. |
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| format | Article |
| id | doaj.art-7ef9333411fe4e45ba7c574a3a90645d |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-10T00:40:24Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-7ef9333411fe4e45ba7c574a3a90645d2023-11-23T15:08:54ZengMDPI AGBiomedicines2227-90592022-08-01109208210.3390/biomedicines10092082The Role of STAMP2 in Pathogenesis of Chronic Diseases Focusing on Nonalcoholic Fatty Liver Disease: A ReviewHye Young Kim0Young Hyun Yoo1Department of Anatomy and Cell Biology and BK21 Program, Department of Translational Biomedical Science, College of Medicine, Dong-A University, Busan 49201, KoreaDepartment of Anatomy and Cell Biology and BK21 Program, Department of Translational Biomedical Science, College of Medicine, Dong-A University, Busan 49201, KoreaNonalcoholic fatty liver disease (NAFLD) is a major health issue. NAFLD can progress from simple hepatic steatosis to nonalcoholic steatohepatitis (NASH). NASH can progress to cirrhosis or hepatocellular carcinoma. Unfortunately, there is no currently approved pharmacologic therapy for NAFLD patients. The six transmembrane protein of prostate 2 (STAMP2), a metalloreductase involved in iron and copper homeostasis, is well known for its critical role in the coordination of glucose/lipid metabolism and inflammation in metabolic tissues. We previously demonstrated that hepatic STAMP2 could be a suitable therapeutic target for NAFLD. In this review, we discuss the emerging role of STAMP2 in the dysregulation of iron metabolism events leading to NAFLD and suggest therapeutic strategies targeting STAMP2.https://www.mdpi.com/2227-9059/10/9/2082NAFLDSTAMP2metalloreductaseiron homeostasis |
| spellingShingle | Hye Young Kim Young Hyun Yoo The Role of STAMP2 in Pathogenesis of Chronic Diseases Focusing on Nonalcoholic Fatty Liver Disease: A Review Biomedicines NAFLD STAMP2 metalloreductase iron homeostasis |
| title | The Role of STAMP2 in Pathogenesis of Chronic Diseases Focusing on Nonalcoholic Fatty Liver Disease: A Review |
| title_full | The Role of STAMP2 in Pathogenesis of Chronic Diseases Focusing on Nonalcoholic Fatty Liver Disease: A Review |
| title_fullStr | The Role of STAMP2 in Pathogenesis of Chronic Diseases Focusing on Nonalcoholic Fatty Liver Disease: A Review |
| title_full_unstemmed | The Role of STAMP2 in Pathogenesis of Chronic Diseases Focusing on Nonalcoholic Fatty Liver Disease: A Review |
| title_short | The Role of STAMP2 in Pathogenesis of Chronic Diseases Focusing on Nonalcoholic Fatty Liver Disease: A Review |
| title_sort | role of stamp2 in pathogenesis of chronic diseases focusing on nonalcoholic fatty liver disease a review |
| topic | NAFLD STAMP2 metalloreductase iron homeostasis |
| url | https://www.mdpi.com/2227-9059/10/9/2082 |
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