Studying the interaction of pentraxin-3 with parameters for assessing the course of chronic heart failure in patients with rheumatoid arthritis
Background. Immunomodulatory cytokines are currently actively used to assess the severity and predict the course of cardiovascular diseases, including heart failure. The purpose of the study was to compare laboratory-instrumental parameters and serum levels of pentraxin-3 in patients with chronic...
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| Format: | Article |
| Language: | English |
| Published: |
Penza State University Publishing House
2022-02-01
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| Series: | Известия высших учебных заведений. Поволжский регион: Медицинские науки |
| Subjects: |
| _version_ | 1828366214740574208 |
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| author | A.S. Ankudinov A.N. Kalyagin |
| author_facet | A.S. Ankudinov A.N. Kalyagin |
| author_sort | A.S. Ankudinov |
| collection | DOAJ |
| description | Background. Immunomodulatory cytokines are currently actively used to assess
the severity and predict the course of cardiovascular diseases, including heart failure. The
purpose of the study was to compare laboratory-instrumental parameters and serum levels
of pentraxin-3 in patients with chronic heart failure (CHF) with preserved and intermediate
left ventricular ejection fraction against the background of rheumatoid arthritis (RA) and
without RA, as well as to study possible associations of pentraxin-3 with laboratoryinstrumental
indicators reflecting the severity of CHF. Materials and methods. The main
group consisted of 134 patients with CHF with RA, and the comparison group consisted of
122 patients without RA. Functional class of CHF that participated in the study of patients
according to NYHAI-II. The diagnosis of RA was made on the basis of X-ray and serological
studies, which included the determination of the concentration of rheumatoid factor, antibodies
to cyclic citrullinated peptide. The activity of the inflammatory process was assessed
using the DAS28 index and the visual analog pain scale. X-ray stage of RA included
in the study of patients I–III according to Steinbroker. The compared groups of patients had
no differences in the nature and volume of therapy taken for heart failure. The basic anti -
inflammatory drug for the treatment of RA is methotrexate. A biochemical and instrumental
study was conducted. The processing was carried out using the program STATISTICA
10.0. The critical level of significance when testing statistical hypotheses is p < 0.05. Results.
The concentration of atrial natriuretic peptide (NT-proBNP) was significantly lower
in the group with RA compared to the group without RA: the level was 306.7 (225; 391)
pg/ml; in the group without RA – 488.7 (355; 638) (p = 0.02). Comparative analysis of
pentraxin-3 levels: 4.5 ± 0.9 and 1.5 ± 0.4, respectively (p = 0.001). An inverse association
of pentraxin-3 and NT-proBNP was found in the group of CHF and RA (r = –0.1;
p = 0.04). Conclusions. In the group of patients with CHF and RA, significantly increased
levels of pentraxin-3 were observed against the background of an inverse association with
NT-proBNP. |
| first_indexed | 2024-04-14T05:42:13Z |
| format | Article |
| id | doaj.art-7ef9e656dfbf4634b52f6063b8fd5580 |
| institution | Directory Open Access Journal |
| issn | 2072-3032 |
| language | English |
| last_indexed | 2024-04-14T05:42:13Z |
| publishDate | 2022-02-01 |
| publisher | Penza State University Publishing House |
| record_format | Article |
| series | Известия высших учебных заведений. Поволжский регион: Медицинские науки |
| spelling | doaj.art-7ef9e656dfbf4634b52f6063b8fd55802022-12-22T02:09:25ZengPenza State University Publishing HouseИзвестия высших учебных заведений. Поволжский регион: Медицинские науки2072-30322022-02-01410.21685/2072-3032-2021-4-1Studying the interaction of pentraxin-3 with parameters for assessing the course of chronic heart failure in patients with rheumatoid arthritisA.S. Ankudinov0A.N. Kalyagin1Irkutsk State Medical UniversityIrkutsk State Medical UniversityBackground. Immunomodulatory cytokines are currently actively used to assess the severity and predict the course of cardiovascular diseases, including heart failure. The purpose of the study was to compare laboratory-instrumental parameters and serum levels of pentraxin-3 in patients with chronic heart failure (CHF) with preserved and intermediate left ventricular ejection fraction against the background of rheumatoid arthritis (RA) and without RA, as well as to study possible associations of pentraxin-3 with laboratoryinstrumental indicators reflecting the severity of CHF. Materials and methods. The main group consisted of 134 patients with CHF with RA, and the comparison group consisted of 122 patients without RA. Functional class of CHF that participated in the study of patients according to NYHAI-II. The diagnosis of RA was made on the basis of X-ray and serological studies, which included the determination of the concentration of rheumatoid factor, antibodies to cyclic citrullinated peptide. The activity of the inflammatory process was assessed using the DAS28 index and the visual analog pain scale. X-ray stage of RA included in the study of patients I–III according to Steinbroker. The compared groups of patients had no differences in the nature and volume of therapy taken for heart failure. The basic anti - inflammatory drug for the treatment of RA is methotrexate. A biochemical and instrumental study was conducted. The processing was carried out using the program STATISTICA 10.0. The critical level of significance when testing statistical hypotheses is p < 0.05. Results. The concentration of atrial natriuretic peptide (NT-proBNP) was significantly lower in the group with RA compared to the group without RA: the level was 306.7 (225; 391) pg/ml; in the group without RA – 488.7 (355; 638) (p = 0.02). Comparative analysis of pentraxin-3 levels: 4.5 ± 0.9 and 1.5 ± 0.4, respectively (p = 0.001). An inverse association of pentraxin-3 and NT-proBNP was found in the group of CHF and RA (r = –0.1; p = 0.04). Conclusions. In the group of patients with CHF and RA, significantly increased levels of pentraxin-3 were observed against the background of an inverse association with NT-proBNP.pentraxin-3chronic heart failurerheumatoid arthritis |
| spellingShingle | A.S. Ankudinov A.N. Kalyagin Studying the interaction of pentraxin-3 with parameters for assessing the course of chronic heart failure in patients with rheumatoid arthritis Известия высших учебных заведений. Поволжский регион: Медицинские науки pentraxin-3 chronic heart failure rheumatoid arthritis |
| title | Studying the interaction of pentraxin-3 with parameters for assessing the course of chronic heart failure in patients with rheumatoid arthritis |
| title_full | Studying the interaction of pentraxin-3 with parameters for assessing the course of chronic heart failure in patients with rheumatoid arthritis |
| title_fullStr | Studying the interaction of pentraxin-3 with parameters for assessing the course of chronic heart failure in patients with rheumatoid arthritis |
| title_full_unstemmed | Studying the interaction of pentraxin-3 with parameters for assessing the course of chronic heart failure in patients with rheumatoid arthritis |
| title_short | Studying the interaction of pentraxin-3 with parameters for assessing the course of chronic heart failure in patients with rheumatoid arthritis |
| title_sort | studying the interaction of pentraxin 3 with parameters for assessing the course of chronic heart failure in patients with rheumatoid arthritis |
| topic | pentraxin-3 chronic heart failure rheumatoid arthritis |
| work_keys_str_mv | AT asankudinov studyingtheinteractionofpentraxin3withparametersforassessingthecourseofchronicheartfailureinpatientswithrheumatoidarthritis AT ankalyagin studyingtheinteractionofpentraxin3withparametersforassessingthecourseofchronicheartfailureinpatientswithrheumatoidarthritis |