Type I vaccine-derived polioviruses in China from 1995 to 2019
A nation-wide case surveillance was conducted in China since 1995 for the objective of identifying acute flaccid paralysis (AFP) in children so that potential wild polioviruses and vaccine-derived poliovirus (VDPV) could be identified on time. Two outbreaks associated with type I circulating VDPVs,...
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| Format: | Article |
| Language: | English |
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Elsevier
2019-12-01
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| Series: | Biosafety and Health |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590053619300461 |
| _version_ | 1818517000640528384 |
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| author | Yong Zhang Shuangli Zhu Dongmei Yan Dongyan Wang Xiaolei Li Hui Zhu Hongqiu An Wenbo Xu |
| author_facet | Yong Zhang Shuangli Zhu Dongmei Yan Dongyan Wang Xiaolei Li Hui Zhu Hongqiu An Wenbo Xu |
| author_sort | Yong Zhang |
| collection | DOAJ |
| description | A nation-wide case surveillance was conducted in China since 1995 for the objective of identifying acute flaccid paralysis (AFP) in children so that potential wild polioviruses and vaccine-derived poliovirus (VDPV) could be identified on time. Two outbreaks associated with type I circulating VDPVs, eight native independent type I ambiguous VDPVs (aVDPV), and one imported aVDPV were identified during the AFP case surveillance in China from 1995 to 2019. The VP1 coding region of the Chinese type I VDPVs differed from the polio vaccine strain by 1.00%–3.75% (9–34 substitutions in 906 nucleotides). Most of the Chinese type I VDPV strains shared 4 amino acid substitutions in the neutralizing antigenic (NAg) sites: 3 located at the BC loop, which formed the NAg site 1, and another at NAg site 3a. All of the Chinese type I VDPVs identified during the AFP case surveillance were young VDPVs, which indicated a limited viral replication resulted from the administration of the initiating oral polio vaccine (OPV) dose. VDPVs can emerge and spread in isolated communities with immunity gaps and the circulation ceases following a mass immunization with OPV. As such, high-quality surveillance permitted very early detection and response and it played a key role in stalling the widespread circulation of the emergent cVDPV strains in China. |
| first_indexed | 2024-12-11T00:50:05Z |
| format | Article |
| id | doaj.art-7efbed22078840418e5532d918d893b6 |
| institution | Directory Open Access Journal |
| issn | 2590-0536 |
| language | English |
| last_indexed | 2024-12-11T00:50:05Z |
| publishDate | 2019-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biosafety and Health |
| spelling | doaj.art-7efbed22078840418e5532d918d893b62022-12-22T01:26:39ZengElsevierBiosafety and Health2590-05362019-12-0113155158Type I vaccine-derived polioviruses in China from 1995 to 2019Yong Zhang0Shuangli Zhu1Dongmei Yan2Dongyan Wang3Xiaolei Li4Hui Zhu5Hongqiu An6Wenbo Xu7WHO WPRO Regional Polio Reference Laboratory and National Laboratory for Poliomyelitis, National Health Commission Key Laboratory for Biosafety, National Health Commission Key Laboratory for Medical Virology, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China; Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan 430071, ChinaWHO WPRO Regional Polio Reference Laboratory and National Laboratory for Poliomyelitis, National Health Commission Key Laboratory for Biosafety, National Health Commission Key Laboratory for Medical Virology, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, ChinaWHO WPRO Regional Polio Reference Laboratory and National Laboratory for Poliomyelitis, National Health Commission Key Laboratory for Biosafety, National Health Commission Key Laboratory for Medical Virology, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, ChinaWHO WPRO Regional Polio Reference Laboratory and National Laboratory for Poliomyelitis, National Health Commission Key Laboratory for Biosafety, National Health Commission Key Laboratory for Medical Virology, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, ChinaWHO WPRO Regional Polio Reference Laboratory and National Laboratory for Poliomyelitis, National Health Commission Key Laboratory for Biosafety, National Health Commission Key Laboratory for Medical Virology, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, ChinaWHO WPRO Regional Polio Reference Laboratory and National Laboratory for Poliomyelitis, National Health Commission Key Laboratory for Biosafety, National Health Commission Key Laboratory for Medical Virology, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, ChinaWHO WPRO Regional Polio Reference Laboratory and National Laboratory for Poliomyelitis, National Health Commission Key Laboratory for Biosafety, National Health Commission Key Laboratory for Medical Virology, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, ChinaWHO WPRO Regional Polio Reference Laboratory and National Laboratory for Poliomyelitis, National Health Commission Key Laboratory for Biosafety, National Health Commission Key Laboratory for Medical Virology, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China; Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan 430071, China; Corresponding author: No. 155, Changbai Road, Changping District, Beijing 102206, China.A nation-wide case surveillance was conducted in China since 1995 for the objective of identifying acute flaccid paralysis (AFP) in children so that potential wild polioviruses and vaccine-derived poliovirus (VDPV) could be identified on time. Two outbreaks associated with type I circulating VDPVs, eight native independent type I ambiguous VDPVs (aVDPV), and one imported aVDPV were identified during the AFP case surveillance in China from 1995 to 2019. The VP1 coding region of the Chinese type I VDPVs differed from the polio vaccine strain by 1.00%–3.75% (9–34 substitutions in 906 nucleotides). Most of the Chinese type I VDPV strains shared 4 amino acid substitutions in the neutralizing antigenic (NAg) sites: 3 located at the BC loop, which formed the NAg site 1, and another at NAg site 3a. All of the Chinese type I VDPVs identified during the AFP case surveillance were young VDPVs, which indicated a limited viral replication resulted from the administration of the initiating oral polio vaccine (OPV) dose. VDPVs can emerge and spread in isolated communities with immunity gaps and the circulation ceases following a mass immunization with OPV. As such, high-quality surveillance permitted very early detection and response and it played a key role in stalling the widespread circulation of the emergent cVDPV strains in China.http://www.sciencedirect.com/science/article/pii/S2590053619300461Type IVaccine-derived poliovirusPhylogenetic analysisNeutralizing antigenic sites |
| spellingShingle | Yong Zhang Shuangli Zhu Dongmei Yan Dongyan Wang Xiaolei Li Hui Zhu Hongqiu An Wenbo Xu Type I vaccine-derived polioviruses in China from 1995 to 2019 Biosafety and Health Type I Vaccine-derived poliovirus Phylogenetic analysis Neutralizing antigenic sites |
| title | Type I vaccine-derived polioviruses in China from 1995 to 2019 |
| title_full | Type I vaccine-derived polioviruses in China from 1995 to 2019 |
| title_fullStr | Type I vaccine-derived polioviruses in China from 1995 to 2019 |
| title_full_unstemmed | Type I vaccine-derived polioviruses in China from 1995 to 2019 |
| title_short | Type I vaccine-derived polioviruses in China from 1995 to 2019 |
| title_sort | type i vaccine derived polioviruses in china from 1995 to 2019 |
| topic | Type I Vaccine-derived poliovirus Phylogenetic analysis Neutralizing antigenic sites |
| url | http://www.sciencedirect.com/science/article/pii/S2590053619300461 |
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