Aspirin Therapy, Cognitive Impairment, and Dementia—A Review
Background: Dementia is associated with a greater burden of cardiovascular risk factors. There is a significant vascular contribution to dementia, and aspirin may play a role in targeting this vascular dysregulation via its anti-inflammatory and antiplatelet effects. We provide an overview of the ef...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-02-01
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| Series: | Future Pharmacology |
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| Online Access: | https://www.mdpi.com/2673-9879/3/1/11 |
| _version_ | 1797611610255130624 |
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| author | Elizabeth H. Thong Edward C. Y. Lee Choi-Ying Yun Tony Y. W. Li Ching-Hui Sia |
| author_facet | Elizabeth H. Thong Edward C. Y. Lee Choi-Ying Yun Tony Y. W. Li Ching-Hui Sia |
| author_sort | Elizabeth H. Thong |
| collection | DOAJ |
| description | Background: Dementia is associated with a greater burden of cardiovascular risk factors. There is a significant vascular contribution to dementia, and aspirin may play a role in targeting this vascular dysregulation via its anti-inflammatory and antiplatelet effects. We provide an overview of the effects of aspirin therapy on the prevention of dementia and cognitive decline in patients with or without dementia and/or cognitive impairment. Methods: We performed a search for studies enrolling adults with or without dementia or MCI and comparing aspirin with placebo, usual care, or active control with respect to cognitive outcomes. Results: We describe aspirin’s effects on the primary prevention of cognitive impairment and various subtypes of dementia, as well as its role in cognitive decline in certain subsets of patients, including those with cerebral small vessel disease (CVSD), coronary heart disease (CHD), and gender differences. Overall, the benefits of aspirin in preventing dementia and cognitive decline remain inconclusive. The majority of cohort studies investigating aspirin’s role in preventing cognitive decline or dementia looked promising, but this was not supported in most randomised controlled trials. However, aspirin may still be beneficial in certain subgroups of patients (such as CHD, VD, and CSVD) and warrants further investigation. |
| first_indexed | 2024-03-11T06:31:08Z |
| format | Article |
| id | doaj.art-7efc27958a75451dad3690b6678145a2 |
| institution | Directory Open Access Journal |
| issn | 2673-9879 |
| language | English |
| last_indexed | 2024-03-11T06:31:08Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Future Pharmacology |
| spelling | doaj.art-7efc27958a75451dad3690b6678145a22023-11-17T11:13:29ZengMDPI AGFuture Pharmacology2673-98792023-02-013114416110.3390/futurepharmacol3010011Aspirin Therapy, Cognitive Impairment, and Dementia—A ReviewElizabeth H. Thong0Edward C. Y. Lee1Choi-Ying Yun2Tony Y. W. Li3Ching-Hui Sia4Department of Cardiology, National University Heart Centre, 1E Kent Ridge Road, National University Health System Tower Block, Level 9, Singapore 119228, SingaporeDepartment of Cardiology, National University Heart Centre, 1E Kent Ridge Road, National University Health System Tower Block, Level 9, Singapore 119228, SingaporeDepartment of Cardiology, National University Heart Centre, 1E Kent Ridge Road, National University Health System Tower Block, Level 9, Singapore 119228, SingaporeDepartment of Cardiology, National University Heart Centre, 1E Kent Ridge Road, National University Health System Tower Block, Level 9, Singapore 119228, SingaporeDepartment of Cardiology, National University Heart Centre, 1E Kent Ridge Road, National University Health System Tower Block, Level 9, Singapore 119228, SingaporeBackground: Dementia is associated with a greater burden of cardiovascular risk factors. There is a significant vascular contribution to dementia, and aspirin may play a role in targeting this vascular dysregulation via its anti-inflammatory and antiplatelet effects. We provide an overview of the effects of aspirin therapy on the prevention of dementia and cognitive decline in patients with or without dementia and/or cognitive impairment. Methods: We performed a search for studies enrolling adults with or without dementia or MCI and comparing aspirin with placebo, usual care, or active control with respect to cognitive outcomes. Results: We describe aspirin’s effects on the primary prevention of cognitive impairment and various subtypes of dementia, as well as its role in cognitive decline in certain subsets of patients, including those with cerebral small vessel disease (CVSD), coronary heart disease (CHD), and gender differences. Overall, the benefits of aspirin in preventing dementia and cognitive decline remain inconclusive. The majority of cohort studies investigating aspirin’s role in preventing cognitive decline or dementia looked promising, but this was not supported in most randomised controlled trials. However, aspirin may still be beneficial in certain subgroups of patients (such as CHD, VD, and CSVD) and warrants further investigation.https://www.mdpi.com/2673-9879/3/1/11aspirinacetylsalicylic acidASAcognitive impairmentcognitive declinedementia |
| spellingShingle | Elizabeth H. Thong Edward C. Y. Lee Choi-Ying Yun Tony Y. W. Li Ching-Hui Sia Aspirin Therapy, Cognitive Impairment, and Dementia—A Review Future Pharmacology aspirin acetylsalicylic acid ASA cognitive impairment cognitive decline dementia |
| title | Aspirin Therapy, Cognitive Impairment, and Dementia—A Review |
| title_full | Aspirin Therapy, Cognitive Impairment, and Dementia—A Review |
| title_fullStr | Aspirin Therapy, Cognitive Impairment, and Dementia—A Review |
| title_full_unstemmed | Aspirin Therapy, Cognitive Impairment, and Dementia—A Review |
| title_short | Aspirin Therapy, Cognitive Impairment, and Dementia—A Review |
| title_sort | aspirin therapy cognitive impairment and dementia a review |
| topic | aspirin acetylsalicylic acid ASA cognitive impairment cognitive decline dementia |
| url | https://www.mdpi.com/2673-9879/3/1/11 |
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