Association of recurrent upper respiratory tract infections with low production of oxygen intermediates in children
Objectives: Upper respiratory tract infections in children generally have significant morbidity and mortality. There is little data available about functional immaturity of the immune system and the child's susceptibility to infections at the beginning of their lives, thus, justifying a more sp...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-07-01
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| Series: | Jornal de Pediatria |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0021755721001467 |
| _version_ | 1829096084672086016 |
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| author | Natália Vieira Inácio Calapodopulos Mônica Miguel Sawan-Mendonça Marcos Vinicius da Silva Carlo Jose Freire Oliveira Virgínia Resende Weffort Denise Bertululucci Rocha Rodrigues Virmondes Rodrigues Jr |
| author_facet | Natália Vieira Inácio Calapodopulos Mônica Miguel Sawan-Mendonça Marcos Vinicius da Silva Carlo Jose Freire Oliveira Virgínia Resende Weffort Denise Bertululucci Rocha Rodrigues Virmondes Rodrigues Jr |
| author_sort | Natália Vieira Inácio Calapodopulos |
| collection | DOAJ |
| description | Objectives: Upper respiratory tract infections in children generally have significant morbidity and mortality. There is little data available about functional immaturity of the immune system and the child's susceptibility to infections at the beginning of their lives, thus, justifying a more specific immunological analysis. Method: Analysis of hemograms and innate and adaptive immune responses in 95 children between age 1 to 6 years with episodes of recurrent respiratory infections (test group n = 39) and without these episodes (control group n = 56) was carried out. The production of reactive oxygen intermediates by peripheral blood cells stimulated by phorbol myristate acetate was analyzed. Additionally, the number of B lymphocytes, auxiliary T lymphocytes, and cytotoxic cells was determined using flow cytometry. Results: Results from both groups did not show statistically significant differences in red blood cells, total leukocytes count, and the differential neutrophils, eosinophils, basophils, lymphocytes, and monocytes count. The analysis of the number of B lymphocytes, auxiliary T lymphocytes (LTCD4), and cytotoxic cells (LTCD8) also did not show any difference between both groups. However, the production of radical oxygen intermediates was significantly reduced in the test group as compared to the control group (p < 0.05). Conclusions: There was no difference in the analysis of hemograms, leukograms, or the number of lymphocytes, LTCD4, LTCD8, or LTCD19. The reduced production of oxygen intermediates in the affected group suggests that these children's microbicide capacity is compromised, which may be related to their recurrent respiratory infections. |
| first_indexed | 2024-04-11T08:50:53Z |
| format | Article |
| id | doaj.art-7efd336ea6ef491ebd16895cbacd869f |
| institution | Directory Open Access Journal |
| issn | 0021-7557 |
| language | English |
| last_indexed | 2024-04-11T08:50:53Z |
| publishDate | 2022-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Jornal de Pediatria |
| spelling | doaj.art-7efd336ea6ef491ebd16895cbacd869f2022-12-22T04:33:35ZengElsevierJornal de Pediatria0021-75572022-07-01984399405Association of recurrent upper respiratory tract infections with low production of oxygen intermediates in childrenNatália Vieira Inácio Calapodopulos0Mônica Miguel Sawan-Mendonça1Marcos Vinicius da Silva2Carlo Jose Freire Oliveira3Virgínia Resende Weffort4Denise Bertululucci Rocha Rodrigues5Virmondes Rodrigues Jr6Universidade Federal do Triângulo Mineiro (UFTM), Departamento Materno Infantil, Uberaba, MG, BrazilUniversidade Federal do Triângulo Mineiro (UFTM), Departamento de Imunologia, Microbiologia e Parasitologia, Uberaba, MG, BrazilUniversidade Federal do Triângulo Mineiro (UFTM), Departamento de Imunologia, Microbiologia e Parasitologia, Uberaba, MG, BrazilUniversidade Federal do Triângulo Mineiro (UFTM), Departamento de Imunologia, Microbiologia e Parasitologia, Uberaba, MG, BrazilUniversidade Federal do Triângulo Mineiro (UFTM), Departamento Materno Infantil, Uberaba, MG, BrazilUniversidade Federal do Triângulo Mineiro (UFTM), Departamento de Imunologia, Microbiologia e Parasitologia, Uberaba, MG, BrazilUniversidade Federal do Triângulo Mineiro (UFTM), Departamento de Imunologia, Microbiologia e Parasitologia, Uberaba, MG, Brazil; Corresponding author.Objectives: Upper respiratory tract infections in children generally have significant morbidity and mortality. There is little data available about functional immaturity of the immune system and the child's susceptibility to infections at the beginning of their lives, thus, justifying a more specific immunological analysis. Method: Analysis of hemograms and innate and adaptive immune responses in 95 children between age 1 to 6 years with episodes of recurrent respiratory infections (test group n = 39) and without these episodes (control group n = 56) was carried out. The production of reactive oxygen intermediates by peripheral blood cells stimulated by phorbol myristate acetate was analyzed. Additionally, the number of B lymphocytes, auxiliary T lymphocytes, and cytotoxic cells was determined using flow cytometry. Results: Results from both groups did not show statistically significant differences in red blood cells, total leukocytes count, and the differential neutrophils, eosinophils, basophils, lymphocytes, and monocytes count. The analysis of the number of B lymphocytes, auxiliary T lymphocytes (LTCD4), and cytotoxic cells (LTCD8) also did not show any difference between both groups. However, the production of radical oxygen intermediates was significantly reduced in the test group as compared to the control group (p < 0.05). Conclusions: There was no difference in the analysis of hemograms, leukograms, or the number of lymphocytes, LTCD4, LTCD8, or LTCD19. The reduced production of oxygen intermediates in the affected group suggests that these children's microbicide capacity is compromised, which may be related to their recurrent respiratory infections.http://www.sciencedirect.com/science/article/pii/S0021755721001467ChildrenRecurrent respiratory infectionsOxygen intermediates |
| spellingShingle | Natália Vieira Inácio Calapodopulos Mônica Miguel Sawan-Mendonça Marcos Vinicius da Silva Carlo Jose Freire Oliveira Virgínia Resende Weffort Denise Bertululucci Rocha Rodrigues Virmondes Rodrigues Jr Association of recurrent upper respiratory tract infections with low production of oxygen intermediates in children Jornal de Pediatria Children Recurrent respiratory infections Oxygen intermediates |
| title | Association of recurrent upper respiratory tract infections with low production of oxygen intermediates in children |
| title_full | Association of recurrent upper respiratory tract infections with low production of oxygen intermediates in children |
| title_fullStr | Association of recurrent upper respiratory tract infections with low production of oxygen intermediates in children |
| title_full_unstemmed | Association of recurrent upper respiratory tract infections with low production of oxygen intermediates in children |
| title_short | Association of recurrent upper respiratory tract infections with low production of oxygen intermediates in children |
| title_sort | association of recurrent upper respiratory tract infections with low production of oxygen intermediates in children |
| topic | Children Recurrent respiratory infections Oxygen intermediates |
| url | http://www.sciencedirect.com/science/article/pii/S0021755721001467 |
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