Cooperative action of SP-A and its trimeric recombinant fragment with polymyxins against Gram-negative respiratory bacteria

Cooperative action of SP-A and its trimeric recombinant fragment with polymyxins against Gram-negative respiratory bacteria

The exploration of therapies combining antimicrobial lung proteins and conventional antibiotics is important due to the growing problem of multidrug-resistant bacteria. The aim of this study was to investigate whether human SP-A and a recombinant trimeric fragment (rfhSP-A) have cooperative antimicr...

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Bibliographic Details
Main Authors: Juan Manuel Coya, Víctor Fraile-Ágreda, Lidia de Tapia, Belén García-Fojeda, Alejandra Sáenz, José A. Bengoechea, Nina Kronqvist, Jan Johansson, Cristina Casals
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Immunology
Subjects:
collectin SP-A
recombinant trimeric fragment
multidrug-resistant bacteria
microbial infection
lung
polymyxin B
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.927017/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.927017/full

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