Study on the Association between <i>LRRC8B</i> Gene InDel and Sheep Body Conformation Traits
Marker-assisted selection is an important method for livestock breeding. In recent years, this technology has been gradually applied to livestock breeding to improve the body conformation traits. In this study, the <i>LRRC8B</i> (Leucine Rich Repeat Containing 8 VRAC Subunit B) gene was...
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MDPI AG
2023-01-01
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| Series: | Genes |
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| Online Access: | https://www.mdpi.com/2073-4425/14/2/356 |
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| author | Jiaqiang Zhang Zhansaya Toremurat Yilin Liang Jie Cheng Zhenzhen Sun Yangming Huang Junxia Liu BUREN Chaogetu Gang Ren Hong Chen |
| author_facet | Jiaqiang Zhang Zhansaya Toremurat Yilin Liang Jie Cheng Zhenzhen Sun Yangming Huang Junxia Liu BUREN Chaogetu Gang Ren Hong Chen |
| author_sort | Jiaqiang Zhang |
| collection | DOAJ |
| description | Marker-assisted selection is an important method for livestock breeding. In recent years, this technology has been gradually applied to livestock breeding to improve the body conformation traits. In this study, the <i>LRRC8B</i> (Leucine Rich Repeat Containing 8 VRAC Subunit B) gene was selected to evaluate the association between its genetic variations and the body conformation traits in two native sheep breeds in China. Four body conformation traits, including withers height, body length, chest circumference, and body weight, were collected from 269 Chaka sheep. We also collected the body length, chest width, withers height, chest depth, chest circumference, cannon bone circumference, and height at hip cross of 149 Small-Tailed Han sheep. Two different genotypes, ID and DD, were detected in all sheep. Our data showed that the polymorphism of the <i>LRRC8B</i> gene was significantly associated with chest depth (<i>p</i> < 0.05) in Small-Tailed Han sheep, and it is greater in sheep with DD than those with ID. In conclusion, our data suggested that the <i>LRRC8B</i> gene could serve as a candidate gene for marker-assisted selection in Small-Tailed Han sheep. |
| first_indexed | 2024-03-11T08:47:00Z |
| format | Article |
| id | doaj.art-7f002213e15949c08b193e4b9bd9bbd4 |
| institution | Directory Open Access Journal |
| issn | 2073-4425 |
| language | English |
| last_indexed | 2024-03-11T08:47:00Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Genes |
| spelling | doaj.art-7f002213e15949c08b193e4b9bd9bbd42023-11-16T20:41:50ZengMDPI AGGenes2073-44252023-01-0114235610.3390/genes14020356Study on the Association between <i>LRRC8B</i> Gene InDel and Sheep Body Conformation TraitsJiaqiang Zhang0Zhansaya Toremurat1Yilin Liang2Jie Cheng3Zhenzhen Sun4Yangming Huang5Junxia Liu6BUREN Chaogetu7Gang Ren8Hong Chen9Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Xianyang 712100, ChinaKey Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Xianyang 712100, ChinaKey Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Xianyang 712100, ChinaKey Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Xianyang 712100, ChinaKey Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Xianyang 712100, ChinaKey Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Xianyang 712100, ChinaCollege of Life Sciences, Northwest A&F University, Xianyang 712100, ChinaAnimal Disease Control Center of Haixi Mongolian and Tibetan Autonomous Prefecture, Delingha 817000, ChinaKey Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Xianyang 712100, ChinaKey Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Xianyang 712100, ChinaMarker-assisted selection is an important method for livestock breeding. In recent years, this technology has been gradually applied to livestock breeding to improve the body conformation traits. In this study, the <i>LRRC8B</i> (Leucine Rich Repeat Containing 8 VRAC Subunit B) gene was selected to evaluate the association between its genetic variations and the body conformation traits in two native sheep breeds in China. Four body conformation traits, including withers height, body length, chest circumference, and body weight, were collected from 269 Chaka sheep. We also collected the body length, chest width, withers height, chest depth, chest circumference, cannon bone circumference, and height at hip cross of 149 Small-Tailed Han sheep. Two different genotypes, ID and DD, were detected in all sheep. Our data showed that the polymorphism of the <i>LRRC8B</i> gene was significantly associated with chest depth (<i>p</i> < 0.05) in Small-Tailed Han sheep, and it is greater in sheep with DD than those with ID. In conclusion, our data suggested that the <i>LRRC8B</i> gene could serve as a candidate gene for marker-assisted selection in Small-Tailed Han sheep.https://www.mdpi.com/2073-4425/14/2/356<i>LRRC8B</i> geneInDelbody conformation traitssheep |
| spellingShingle | Jiaqiang Zhang Zhansaya Toremurat Yilin Liang Jie Cheng Zhenzhen Sun Yangming Huang Junxia Liu BUREN Chaogetu Gang Ren Hong Chen Study on the Association between <i>LRRC8B</i> Gene InDel and Sheep Body Conformation Traits Genes <i>LRRC8B</i> gene InDel body conformation traits sheep |
| title | Study on the Association between <i>LRRC8B</i> Gene InDel and Sheep Body Conformation Traits |
| title_full | Study on the Association between <i>LRRC8B</i> Gene InDel and Sheep Body Conformation Traits |
| title_fullStr | Study on the Association between <i>LRRC8B</i> Gene InDel and Sheep Body Conformation Traits |
| title_full_unstemmed | Study on the Association between <i>LRRC8B</i> Gene InDel and Sheep Body Conformation Traits |
| title_short | Study on the Association between <i>LRRC8B</i> Gene InDel and Sheep Body Conformation Traits |
| title_sort | study on the association between i lrrc8b i gene indel and sheep body conformation traits |
| topic | <i>LRRC8B</i> gene InDel body conformation traits sheep |
| url | https://www.mdpi.com/2073-4425/14/2/356 |
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