Pathologic HDAC1/c-Myc signaling axis is responsible for angiotensinogen transcription and hypertension induced by high-fat diet

Pathologic HDAC1/c-Myc signaling axis is responsible for angiotensinogen transcription and hypertension induced by high-fat diet

High-fat diet (HFD)-induced obesity is a cause of resistant hypertension. We have shown a possible link between histone deacetylases (HDACs) and renal angiotensinogen (Agt) upregulation in the HFD-induced hypertension, whereas the underlying mechanisms remain to be elucidated. Here, using a HDAC1/2...

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Bibliographic Details
Main Authors: Eui Kyung Youn, Hyun Min Cho, Jin Ki Jung, Ga-Eun Yoon, Masumi Eto, Jee In Kim
Format: Article
Language:English
Published: Elsevier 2023-08-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Obesity-associated hypertension
Histone deacetylase 1
Cellular myelocytomatosis oncogene
Angiotensinogen
Epigenetic regulation
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332223007163

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