Development of a concentration‐controlled sequential nanoprecipitation for making lipid nanoparticles with high drug loading
Abstract Lipid‐based nanostructures have garnered considerable interests over the last two decades, and have achieved tremendous clinical success including the first clinical approval of a liposome (Doxil) for cancer therapy in 1995 and the recent COVID‐19 mRNA lipid nanoparticle vaccines. Compared...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-12-01
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| Series: | Aggregate |
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| Online Access: | https://doi.org/10.1002/agt2.369 |
| _version_ | 1797386782327701504 |
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| author | Letao Xu Xing Wang Guangze Yang Zihan Zhao Yilun Weng Yang Li Yun Liu Chun‐Xia Zhao |
| author_facet | Letao Xu Xing Wang Guangze Yang Zihan Zhao Yilun Weng Yang Li Yun Liu Chun‐Xia Zhao |
| author_sort | Letao Xu |
| collection | DOAJ |
| description | Abstract Lipid‐based nanostructures have garnered considerable interests over the last two decades, and have achieved tremendous clinical success including the first clinical approval of a liposome (Doxil) for cancer therapy in 1995 and the recent COVID‐19 mRNA lipid nanoparticle vaccines. Compared to liposomes which have a lipid bilayer surrounding an aqueous core, lipid nanoparticles with a particle structure have several attractive advantages for encapsulating poorly water‐soluble drugs such as better stability due to the particle structure, high drug encapsulation efficiency because of a pre‐ or co‐drug‐loading strategy. While many studies have reported the synthesis of lipid nanoparticles for hydrophobic drug encapsulation, the precise control of drug loading and encapsulation efficiency remains a significant challenge. This work reports a new concentration‐controlled nanoprecipitation platform technology for fabricating lipid nanoparticles with tunable drug loading up to 70 wt%. This method is applicable for encapsulating a wide range of drugs from very hydrophobic to slightly hydrophilic. Using this facile method, nanoparticles with tunable drug loading exhibited excellent properties such as small particle size, narrow size distribution, good particle stability, showing great promise for future drug delivery applications. |
| first_indexed | 2024-03-08T22:14:19Z |
| format | Article |
| id | doaj.art-7f005b326b754834a48afa97c05d4148 |
| institution | Directory Open Access Journal |
| issn | 2692-4560 |
| language | English |
| last_indexed | 2024-03-08T22:14:19Z |
| publishDate | 2023-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Aggregate |
| spelling | doaj.art-7f005b326b754834a48afa97c05d41482023-12-19T04:23:02ZengWileyAggregate2692-45602023-12-0146n/an/a10.1002/agt2.369Development of a concentration‐controlled sequential nanoprecipitation for making lipid nanoparticles with high drug loadingLetao Xu0Xing Wang1Guangze Yang2Zihan Zhao3Yilun Weng4Yang Li5Yun Liu6Chun‐Xia Zhao7Australian Institute for Bioengineering and Nanotechnology The University of Queensland St. Lucia Queensland AustraliaSchool of Chemical Engineering Faculty of Sciences Engineering and Technology The University of Adelaide Adelaide South Australia AustraliaSchool of Chemical Engineering Faculty of Sciences Engineering and Technology The University of Adelaide Adelaide South Australia AustraliaSchool of Chemical Engineering Faculty of Sciences Engineering and Technology The University of Adelaide Adelaide South Australia AustraliaAustralian Institute for Bioengineering and Nanotechnology The University of Queensland St. Lucia Queensland AustraliaAustralian Institute for Bioengineering and Nanotechnology The University of Queensland St. Lucia Queensland AustraliaSchool of Chemical Engineering Faculty of Sciences Engineering and Technology The University of Adelaide Adelaide South Australia AustraliaAustralian Institute for Bioengineering and Nanotechnology The University of Queensland St. Lucia Queensland AustraliaAbstract Lipid‐based nanostructures have garnered considerable interests over the last two decades, and have achieved tremendous clinical success including the first clinical approval of a liposome (Doxil) for cancer therapy in 1995 and the recent COVID‐19 mRNA lipid nanoparticle vaccines. Compared to liposomes which have a lipid bilayer surrounding an aqueous core, lipid nanoparticles with a particle structure have several attractive advantages for encapsulating poorly water‐soluble drugs such as better stability due to the particle structure, high drug encapsulation efficiency because of a pre‐ or co‐drug‐loading strategy. While many studies have reported the synthesis of lipid nanoparticles for hydrophobic drug encapsulation, the precise control of drug loading and encapsulation efficiency remains a significant challenge. This work reports a new concentration‐controlled nanoprecipitation platform technology for fabricating lipid nanoparticles with tunable drug loading up to 70 wt%. This method is applicable for encapsulating a wide range of drugs from very hydrophobic to slightly hydrophilic. Using this facile method, nanoparticles with tunable drug loading exhibited excellent properties such as small particle size, narrow size distribution, good particle stability, showing great promise for future drug delivery applications.https://doi.org/10.1002/agt2.369controlled releasedrug deliverydrug loadinglipid nanoparticlesnanoprecipitation |
| spellingShingle | Letao Xu Xing Wang Guangze Yang Zihan Zhao Yilun Weng Yang Li Yun Liu Chun‐Xia Zhao Development of a concentration‐controlled sequential nanoprecipitation for making lipid nanoparticles with high drug loading Aggregate controlled release drug delivery drug loading lipid nanoparticles nanoprecipitation |
| title | Development of a concentration‐controlled sequential nanoprecipitation for making lipid nanoparticles with high drug loading |
| title_full | Development of a concentration‐controlled sequential nanoprecipitation for making lipid nanoparticles with high drug loading |
| title_fullStr | Development of a concentration‐controlled sequential nanoprecipitation for making lipid nanoparticles with high drug loading |
| title_full_unstemmed | Development of a concentration‐controlled sequential nanoprecipitation for making lipid nanoparticles with high drug loading |
| title_short | Development of a concentration‐controlled sequential nanoprecipitation for making lipid nanoparticles with high drug loading |
| title_sort | development of a concentration controlled sequential nanoprecipitation for making lipid nanoparticles with high drug loading |
| topic | controlled release drug delivery drug loading lipid nanoparticles nanoprecipitation |
| url | https://doi.org/10.1002/agt2.369 |
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