Three-year changes in sex judgment using color fundus parameters in elementary school students.
<h4>Purpose</h4>In a previous cross-sectional study, we reported that the sexes can be distinguished using known factors obtained from color fundus photography (CFP). However, it is not clear how sex differences in fundus parameters appear across the human lifespan. Therefore, we conduct...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2023-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0295123&type=printable |
| _version_ | 1797374098543738880 |
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| author | Takehiro Yamashita Ryo Asaoka Hiroto Terasaki Naoya Yoshihara Naoko Kakiuchi Taiji Sakamoto |
| author_facet | Takehiro Yamashita Ryo Asaoka Hiroto Terasaki Naoya Yoshihara Naoko Kakiuchi Taiji Sakamoto |
| author_sort | Takehiro Yamashita |
| collection | DOAJ |
| description | <h4>Purpose</h4>In a previous cross-sectional study, we reported that the sexes can be distinguished using known factors obtained from color fundus photography (CFP). However, it is not clear how sex differences in fundus parameters appear across the human lifespan. Therefore, we conducted a cohort study to investigate sex determination based on fundus parameters in elementary school students.<h4>Methods</h4>This prospective observational longitudinal study investigated 109 right eyes of elementary school students over 4 years (age, 8.5 to 11.5 years). From each CFP, the tessellation fundus index was calculated as red/red + green + blue (R/[R+G+B]) using the mean value of red-green-blue intensity in eight locations around the optic disc and macular region. Optic disc area, ovality ratio, papillomacular angle, and retinal vessel angles and distances were quantified according to the data in our previous report. Using 54 fundus parameters, sex was predicted by L2 regularized binomial logistic regression for each grade.<h4>Results</h4>The right eyes of 53 boys and 56 girls were analyzed. The discrimination accuracy rate significantly increased with age: 56.3% at 8.5 years, 46.1% at 9.5 years, 65.5% at 10.5 years and 73.1% at 11.5 years.<h4>Conclusions</h4>The accuracy of sex discrimination by fundus photography improved during a 3-year cohort study of elementary school students. |
| first_indexed | 2024-03-08T18:59:56Z |
| format | Article |
| id | doaj.art-7f01033831d54d04888dce4379aade42 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-03-08T18:59:56Z |
| publishDate | 2023-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-7f01033831d54d04888dce4379aade422023-12-28T05:31:24ZengPublic Library of Science (PLoS)PLoS ONE1932-62032023-01-011811e029512310.1371/journal.pone.0295123Three-year changes in sex judgment using color fundus parameters in elementary school students.Takehiro YamashitaRyo AsaokaHiroto TerasakiNaoya YoshiharaNaoko KakiuchiTaiji Sakamoto<h4>Purpose</h4>In a previous cross-sectional study, we reported that the sexes can be distinguished using known factors obtained from color fundus photography (CFP). However, it is not clear how sex differences in fundus parameters appear across the human lifespan. Therefore, we conducted a cohort study to investigate sex determination based on fundus parameters in elementary school students.<h4>Methods</h4>This prospective observational longitudinal study investigated 109 right eyes of elementary school students over 4 years (age, 8.5 to 11.5 years). From each CFP, the tessellation fundus index was calculated as red/red + green + blue (R/[R+G+B]) using the mean value of red-green-blue intensity in eight locations around the optic disc and macular region. Optic disc area, ovality ratio, papillomacular angle, and retinal vessel angles and distances were quantified according to the data in our previous report. Using 54 fundus parameters, sex was predicted by L2 regularized binomial logistic regression for each grade.<h4>Results</h4>The right eyes of 53 boys and 56 girls were analyzed. The discrimination accuracy rate significantly increased with age: 56.3% at 8.5 years, 46.1% at 9.5 years, 65.5% at 10.5 years and 73.1% at 11.5 years.<h4>Conclusions</h4>The accuracy of sex discrimination by fundus photography improved during a 3-year cohort study of elementary school students.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0295123&type=printable |
| spellingShingle | Takehiro Yamashita Ryo Asaoka Hiroto Terasaki Naoya Yoshihara Naoko Kakiuchi Taiji Sakamoto Three-year changes in sex judgment using color fundus parameters in elementary school students. PLoS ONE |
| title | Three-year changes in sex judgment using color fundus parameters in elementary school students. |
| title_full | Three-year changes in sex judgment using color fundus parameters in elementary school students. |
| title_fullStr | Three-year changes in sex judgment using color fundus parameters in elementary school students. |
| title_full_unstemmed | Three-year changes in sex judgment using color fundus parameters in elementary school students. |
| title_short | Three-year changes in sex judgment using color fundus parameters in elementary school students. |
| title_sort | three year changes in sex judgment using color fundus parameters in elementary school students |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0295123&type=printable |
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