Inhibition of spinal bone formation in AS: 10 years after comparing adalimumab to OASIS
Abstract A decade has passed since the publication on the comparison of the effect of adalimumab with data from a historic cohort on the progression of structural damage in the spine of patients with ankylosing spondylitis (AS). No effect could be observed, and currently, there is still no definite...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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BMC
2019-11-01
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| Series: | Arthritis Research & Therapy |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13075-019-2045-1 |
| _version_ | 1828774316023480320 |
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| author | Désirée van der Heijde Robert Landewé |
| author_facet | Désirée van der Heijde Robert Landewé |
| author_sort | Désirée van der Heijde |
| collection | DOAJ |
| description | Abstract A decade has passed since the publication on the comparison of the effect of adalimumab with data from a historic cohort on the progression of structural damage in the spine of patients with ankylosing spondylitis (AS). No effect could be observed, and currently, there is still no definite proof that TNF inhibitors (TNFi) inhibit spinal structural damage. The findings of the publication are discussed within the context of the time at the publication and new developments. |
| first_indexed | 2024-12-11T15:19:06Z |
| format | Article |
| id | doaj.art-7f0199498d7b4e53acf90cd730ca6dfb |
| institution | Directory Open Access Journal |
| issn | 1478-6362 |
| language | English |
| last_indexed | 2024-12-11T15:19:06Z |
| publishDate | 2019-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Arthritis Research & Therapy |
| spelling | doaj.art-7f0199498d7b4e53acf90cd730ca6dfb2022-12-22T01:00:27ZengBMCArthritis Research & Therapy1478-63622019-11-012111310.1186/s13075-019-2045-1Inhibition of spinal bone formation in AS: 10 years after comparing adalimumab to OASISDésirée van der Heijde0Robert Landewé1Department of Rheumatology, Leiden University Medical CenterAmsterdam University Medical Center (ARC)Abstract A decade has passed since the publication on the comparison of the effect of adalimumab with data from a historic cohort on the progression of structural damage in the spine of patients with ankylosing spondylitis (AS). No effect could be observed, and currently, there is still no definite proof that TNF inhibitors (TNFi) inhibit spinal structural damage. The findings of the publication are discussed within the context of the time at the publication and new developments.http://link.springer.com/article/10.1186/s13075-019-2045-1Ankylosing spondylitisStructural damageTNF inhibitor |
| spellingShingle | Désirée van der Heijde Robert Landewé Inhibition of spinal bone formation in AS: 10 years after comparing adalimumab to OASIS Arthritis Research & Therapy Ankylosing spondylitis Structural damage TNF inhibitor |
| title | Inhibition of spinal bone formation in AS: 10 years after comparing adalimumab to OASIS |
| title_full | Inhibition of spinal bone formation in AS: 10 years after comparing adalimumab to OASIS |
| title_fullStr | Inhibition of spinal bone formation in AS: 10 years after comparing adalimumab to OASIS |
| title_full_unstemmed | Inhibition of spinal bone formation in AS: 10 years after comparing adalimumab to OASIS |
| title_short | Inhibition of spinal bone formation in AS: 10 years after comparing adalimumab to OASIS |
| title_sort | inhibition of spinal bone formation in as 10 years after comparing adalimumab to oasis |
| topic | Ankylosing spondylitis Structural damage TNF inhibitor |
| url | http://link.springer.com/article/10.1186/s13075-019-2045-1 |
| work_keys_str_mv | AT desireevanderheijde inhibitionofspinalboneformationinas10yearsaftercomparingadalimumabtooasis AT robertlandewe inhibitionofspinalboneformationinas10yearsaftercomparingadalimumabtooasis |