Prevalence of oral mucosal lesions in patients with systemic Lupus Erythematosus: a systematic review and meta-analysis
Abstract Background Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that can cause a range of symptoms, including oral mucosal lesions (OMLs). The prevalence of OMLs in SLE patients and their associated factors have been studied in various regions, but the results are inconsistent...
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| Format: | Article |
| Language: | English |
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BMC
2023-12-01
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| Series: | BMC Oral Health |
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| Online Access: | https://doi.org/10.1186/s12903-023-03783-5 |
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| author | Fei Du Wanying Qian Xinna Zhang Le Zhang Jianwei Shang |
| author_facet | Fei Du Wanying Qian Xinna Zhang Le Zhang Jianwei Shang |
| author_sort | Fei Du |
| collection | DOAJ |
| description | Abstract Background Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that can cause a range of symptoms, including oral mucosal lesions (OMLs). The prevalence of OMLs in SLE patients and their associated factors have been studied in various regions, but the results are inconsistent. This study aims to evaluate the prevalence of OMLs in patients with SLE. Methods Observational studies of OML prevalence in SLE patients published before 2022 were retrieved from PubMed, Embase, Web of Science, Google Scholar, and the Cochrane Library without language restriction. The quality of the studies was assessed using the Newcastle-Ottawa Scale (NOS) and Agency for Healthcare Research and Quality (AHRQ). Results Our meta-analysis included 113 studies with a total of 53,307 SLE patients. We found that the prevalence of OMLs in SLE patients was 31% (95% CI: 28%, 35%), with oral ulcers being present in 30% of SLE patients (95% CI: 26%, 33%). Subgroup analysis showed that the prevalence of OMLs varied significantly by region, disease activity, and sample size (p ≤ 0.01). However, gender and year of publication had little effect on the prevalence of OMLs (p = 0.78 and 0.30, respectively). Oral ulcers were significantly associated with age of onset (p = 0.02), geographic location (p < 0.01), and race (p < 0.01). We also found that the prevalence of oral erythema was 9%, oral candidiasis was 9%, petechiae was 8%, cheilitis was 6%, and white plaque was 3%. Conclusions Our analysis showed that the prevalence of OMLs varied significantly by region and disease activity, and child-onset patients of Indian, Malay, and Caucasian descent were more likely to have oral ulcers. The high prevalence of OML in SLE patients emphasizes the importance of regular oral examination and management in the comprehensive care of individuals with SLE. |
| first_indexed | 2024-03-08T19:43:29Z |
| format | Article |
| id | doaj.art-7f04f21df8294451b90194cc74b1cf8b |
| institution | Directory Open Access Journal |
| issn | 1472-6831 |
| language | English |
| last_indexed | 2024-03-08T19:43:29Z |
| publishDate | 2023-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Oral Health |
| spelling | doaj.art-7f04f21df8294451b90194cc74b1cf8b2023-12-24T12:31:16ZengBMCBMC Oral Health1472-68312023-12-0123111010.1186/s12903-023-03783-5Prevalence of oral mucosal lesions in patients with systemic Lupus Erythematosus: a systematic review and meta-analysisFei Du0Wanying Qian1Xinna Zhang2Le Zhang3Jianwei Shang4Department of Oral Pathology, School of Medicine, Tianjin Stomatological Hospital, Nankai UniversityDepartment of Oral Pathology, School of Medicine, Tianjin Stomatological Hospital, Nankai UniversityDepartment of Oral Pathology, School of Medicine, Tianjin Stomatological Hospital, Nankai UniversityDepartment of Oral Pathology, School of Medicine, Tianjin Stomatological Hospital, Nankai UniversityDepartment of Oral Pathology, School of Medicine, Tianjin Stomatological Hospital, Nankai UniversityAbstract Background Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that can cause a range of symptoms, including oral mucosal lesions (OMLs). The prevalence of OMLs in SLE patients and their associated factors have been studied in various regions, but the results are inconsistent. This study aims to evaluate the prevalence of OMLs in patients with SLE. Methods Observational studies of OML prevalence in SLE patients published before 2022 were retrieved from PubMed, Embase, Web of Science, Google Scholar, and the Cochrane Library without language restriction. The quality of the studies was assessed using the Newcastle-Ottawa Scale (NOS) and Agency for Healthcare Research and Quality (AHRQ). Results Our meta-analysis included 113 studies with a total of 53,307 SLE patients. We found that the prevalence of OMLs in SLE patients was 31% (95% CI: 28%, 35%), with oral ulcers being present in 30% of SLE patients (95% CI: 26%, 33%). Subgroup analysis showed that the prevalence of OMLs varied significantly by region, disease activity, and sample size (p ≤ 0.01). However, gender and year of publication had little effect on the prevalence of OMLs (p = 0.78 and 0.30, respectively). Oral ulcers were significantly associated with age of onset (p = 0.02), geographic location (p < 0.01), and race (p < 0.01). We also found that the prevalence of oral erythema was 9%, oral candidiasis was 9%, petechiae was 8%, cheilitis was 6%, and white plaque was 3%. Conclusions Our analysis showed that the prevalence of OMLs varied significantly by region and disease activity, and child-onset patients of Indian, Malay, and Caucasian descent were more likely to have oral ulcers. The high prevalence of OML in SLE patients emphasizes the importance of regular oral examination and management in the comprehensive care of individuals with SLE.https://doi.org/10.1186/s12903-023-03783-5Lupus Erythematosus, systemicOral mucosal lesionsPrevalenceMeta-analysis |
| spellingShingle | Fei Du Wanying Qian Xinna Zhang Le Zhang Jianwei Shang Prevalence of oral mucosal lesions in patients with systemic Lupus Erythematosus: a systematic review and meta-analysis BMC Oral Health Lupus Erythematosus, systemic Oral mucosal lesions Prevalence Meta-analysis |
| title | Prevalence of oral mucosal lesions in patients with systemic Lupus Erythematosus: a systematic review and meta-analysis |
| title_full | Prevalence of oral mucosal lesions in patients with systemic Lupus Erythematosus: a systematic review and meta-analysis |
| title_fullStr | Prevalence of oral mucosal lesions in patients with systemic Lupus Erythematosus: a systematic review and meta-analysis |
| title_full_unstemmed | Prevalence of oral mucosal lesions in patients with systemic Lupus Erythematosus: a systematic review and meta-analysis |
| title_short | Prevalence of oral mucosal lesions in patients with systemic Lupus Erythematosus: a systematic review and meta-analysis |
| title_sort | prevalence of oral mucosal lesions in patients with systemic lupus erythematosus a systematic review and meta analysis |
| topic | Lupus Erythematosus, systemic Oral mucosal lesions Prevalence Meta-analysis |
| url | https://doi.org/10.1186/s12903-023-03783-5 |
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