The interaction between ferroptosis and inflammatory signaling pathways
Abstract Ferroptosis is an iron-dependent regulated cell death driven by excessive lipid peroxidation. Inflammation is one common and effective physiological event that protects against various stimuli to maintain tissue homeostasis. However, the dysregulation of inflammatory responses can cause imb...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2023-03-01
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| Series: | Cell Death and Disease |
| Online Access: | https://doi.org/10.1038/s41419-023-05716-0 |
| _version_ | 1827982575379939328 |
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| author | Yue Chen Ze-Min Fang Xin Yi Xiang Wei Ding-Sheng Jiang |
| author_facet | Yue Chen Ze-Min Fang Xin Yi Xiang Wei Ding-Sheng Jiang |
| author_sort | Yue Chen |
| collection | DOAJ |
| description | Abstract Ferroptosis is an iron-dependent regulated cell death driven by excessive lipid peroxidation. Inflammation is one common and effective physiological event that protects against various stimuli to maintain tissue homeostasis. However, the dysregulation of inflammatory responses can cause imbalance of the immune system, cell dysfunction and death. Recent studies have pointed out that activation of inflammation, including the activation of multiple inflammation-related signaling pathways, can lead to ferroptosis. Among the related signal transduction pathways, we focused on five classical inflammatory pathways, namely, the JAK-STAT, NF-κB, inflammasome, cGAS-STING and MAPK signaling pathways, and expounded on their roles in ferroptosis. To date, many agents have shown therapeutic effects on ferroptosis-related diseases by modulating the aforementioned pathways in vivo and in vitro. Moreover, the regulatory effects of these pathways on iron metabolism and lipid peroxidation have been described in detail, contributing to further understanding of the pathophysiological process of ferroptosis. Taken together, targeting these pathways related to inflammation will provide appropriate ways to intervene ferroptosis and diseases. |
| first_indexed | 2024-04-09T22:35:05Z |
| format | Article |
| id | doaj.art-7f0615b209994392ae498407e6782701 |
| institution | Directory Open Access Journal |
| issn | 2041-4889 |
| language | English |
| last_indexed | 2024-04-09T22:35:05Z |
| publishDate | 2023-03-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Cell Death and Disease |
| spelling | doaj.art-7f0615b209994392ae498407e67827012023-03-22T12:32:06ZengNature Publishing GroupCell Death and Disease2041-48892023-03-0114311310.1038/s41419-023-05716-0The interaction between ferroptosis and inflammatory signaling pathwaysYue Chen0Ze-Min Fang1Xin Yi2Xiang Wei3Ding-Sheng Jiang4Division of Cardiothoracic and Vascular Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDivision of Cardiothoracic and Vascular Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Cardiology, Renmin Hospital of Wuhan UniversityDivision of Cardiothoracic and Vascular Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDivision of Cardiothoracic and Vascular Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyAbstract Ferroptosis is an iron-dependent regulated cell death driven by excessive lipid peroxidation. Inflammation is one common and effective physiological event that protects against various stimuli to maintain tissue homeostasis. However, the dysregulation of inflammatory responses can cause imbalance of the immune system, cell dysfunction and death. Recent studies have pointed out that activation of inflammation, including the activation of multiple inflammation-related signaling pathways, can lead to ferroptosis. Among the related signal transduction pathways, we focused on five classical inflammatory pathways, namely, the JAK-STAT, NF-κB, inflammasome, cGAS-STING and MAPK signaling pathways, and expounded on their roles in ferroptosis. To date, many agents have shown therapeutic effects on ferroptosis-related diseases by modulating the aforementioned pathways in vivo and in vitro. Moreover, the regulatory effects of these pathways on iron metabolism and lipid peroxidation have been described in detail, contributing to further understanding of the pathophysiological process of ferroptosis. Taken together, targeting these pathways related to inflammation will provide appropriate ways to intervene ferroptosis and diseases.https://doi.org/10.1038/s41419-023-05716-0 |
| spellingShingle | Yue Chen Ze-Min Fang Xin Yi Xiang Wei Ding-Sheng Jiang The interaction between ferroptosis and inflammatory signaling pathways Cell Death and Disease |
| title | The interaction between ferroptosis and inflammatory signaling pathways |
| title_full | The interaction between ferroptosis and inflammatory signaling pathways |
| title_fullStr | The interaction between ferroptosis and inflammatory signaling pathways |
| title_full_unstemmed | The interaction between ferroptosis and inflammatory signaling pathways |
| title_short | The interaction between ferroptosis and inflammatory signaling pathways |
| title_sort | interaction between ferroptosis and inflammatory signaling pathways |
| url | https://doi.org/10.1038/s41419-023-05716-0 |
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