Translating genetic research into preventive intervention: The baseline target moderated mediator design
In this paper we present and discuss a novel research approach, the baseline target moderated mediation (BTMM) design, that holds substantial promise for advancing our understanding of how genetic research can inform prevention research. We first discuss how genetically informed research on develop...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2016-01-01
|
| Series: | Frontiers in Psychology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fpsyg.2015.01911/full |
| _version_ | 1828267304456028160 |
|---|---|
| author | George W. Howe |
| author_facet | George W. Howe |
| author_sort | George W. Howe |
| collection | DOAJ |
| description | In this paper we present and discuss a novel research approach, the baseline target moderated mediation (BTMM) design, that holds substantial promise for advancing our understanding of how genetic research can inform prevention research. We first discuss how genetically informed research on developmental psychopathology can be used to identify potential intervention targets. We then describe the BTMM design, which employs moderated mediation within a longitudinal study to test whether baseline levels of intervention targets moderate the impact of the intervention on change in that target, and whether change in those targets mediates causal impact of preventive or treatment interventions on distal health outcomes. We next discuss how genetically informed BTMM designs can be applied to both microtrials and full-scale prevention trials. We end with a discussion of some of the advantages and limitations of this approach. |
| first_indexed | 2024-04-13T05:02:43Z |
| format | Article |
| id | doaj.art-7f0631283ccb4b78ad84f8334f6f3c5c |
| institution | Directory Open Access Journal |
| issn | 1664-1078 |
| language | English |
| last_indexed | 2024-04-13T05:02:43Z |
| publishDate | 2016-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychology |
| spelling | doaj.art-7f0631283ccb4b78ad84f8334f6f3c5c2022-12-22T03:01:16ZengFrontiers Media S.A.Frontiers in Psychology1664-10782016-01-01610.3389/fpsyg.2015.01911152495Translating genetic research into preventive intervention: The baseline target moderated mediator designGeorge W. Howe0George Washington UniversityIn this paper we present and discuss a novel research approach, the baseline target moderated mediation (BTMM) design, that holds substantial promise for advancing our understanding of how genetic research can inform prevention research. We first discuss how genetically informed research on developmental psychopathology can be used to identify potential intervention targets. We then describe the BTMM design, which employs moderated mediation within a longitudinal study to test whether baseline levels of intervention targets moderate the impact of the intervention on change in that target, and whether change in those targets mediates causal impact of preventive or treatment interventions on distal health outcomes. We next discuss how genetically informed BTMM designs can be applied to both microtrials and full-scale prevention trials. We end with a discussion of some of the advantages and limitations of this approach.http://journal.frontiersin.org/Journal/10.3389/fpsyg.2015.01911/fullGenesResearch Designgene-environment interactionMediation analysismoderation analysisprevention research |
| spellingShingle | George W. Howe Translating genetic research into preventive intervention: The baseline target moderated mediator design Frontiers in Psychology Genes Research Design gene-environment interaction Mediation analysis moderation analysis prevention research |
| title | Translating genetic research into preventive intervention: The baseline target moderated mediator design |
| title_full | Translating genetic research into preventive intervention: The baseline target moderated mediator design |
| title_fullStr | Translating genetic research into preventive intervention: The baseline target moderated mediator design |
| title_full_unstemmed | Translating genetic research into preventive intervention: The baseline target moderated mediator design |
| title_short | Translating genetic research into preventive intervention: The baseline target moderated mediator design |
| title_sort | translating genetic research into preventive intervention the baseline target moderated mediator design |
| topic | Genes Research Design gene-environment interaction Mediation analysis moderation analysis prevention research |
| url | http://journal.frontiersin.org/Journal/10.3389/fpsyg.2015.01911/full |
| work_keys_str_mv | AT georgewhowe translatinggeneticresearchintopreventiveinterventionthebaselinetargetmoderatedmediatordesign |