Structure-function relationships in glaucoma using enhanced depth imaging optical coherence tomography-derived parameters: a cross-sectional observational study
Abstract Background To investigate structural and functional correlations in glaucoma patients using enhanced depth imaging spectral-domain optical coherence tomography (EDI OCT)-derived parameters. Methods We prospectively enrolled healthy participants and glaucomatous patients with a wide range of...
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| Format: | Article |
| Language: | English |
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BMC
2019-02-01
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| Series: | BMC Ophthalmology |
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| Online Access: | http://link.springer.com/article/10.1186/s12886-019-1054-9 |
| _version_ | 1818286443899912192 |
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| author | Flavio S. Lopes Igor Matsubara Izabela Almeida Syril K. Dorairaj Roberto M. Vessani Augusto Paranhos Jr Tiago S. Prata |
| author_facet | Flavio S. Lopes Igor Matsubara Izabela Almeida Syril K. Dorairaj Roberto M. Vessani Augusto Paranhos Jr Tiago S. Prata |
| author_sort | Flavio S. Lopes |
| collection | DOAJ |
| description | Abstract Background To investigate structural and functional correlations in glaucoma patients using enhanced depth imaging spectral-domain optical coherence tomography (EDI OCT)-derived parameters. Methods We prospectively enrolled healthy participants and glaucomatous patients with a wide range of disease stages. All participants underwent visual field (VF) testing (SITA - Standard 24–2; Carl Zeiss Meditec, Dublin, CA) and EDI OCT imaging (Spectralis; Heidelberg Engineering Co., Heidelberg, Germany). The following optic nerve head parameters were measured on serial vertical EDI OCT B-scans by two experienced examiners masked to patients clinical data: lamina cribrosa (LC) thickness and area, prelaminar neural tissue thickness and area, anterior LC depth, Bruch’s membrane opening (BMO) and average, superior, and inferior BMO-minimum rim width (BMO-MRW). Only good quality images were considered, and whenever both eyes were eligible, one was randomly selected for analysis. Scatter plots were constructed to investigate correlations between each anatomic parameter and patient’s VF status (based on VF index [VFI] values). Results A total of 73 eyes of 73 patients were included. All EDI OCT parameters evaluated differed significantly between glaucomatous and control eyes (P ≤ 0.045). A secondary analysis, in which glaucomatous patients were divided according to VF mean deviation index values into 3 groups (mild [G1; > − 6 dB], moderate [G2; − 6 to − 12 dB] and advanced [G3; <− 12 dB] glaucoma), revealed that average BMO-MRW was the EDI OCT parameter that presented more significant differences between the different stages of glaucoma. Significant structure-function correlations were found between VFI values and prelaminar neural tissue area (R2 = 0.20, P = 0.017), average BMO-MRW (R2 = 0.35, P ≤ 0.001), superior BMO-MRW (R2 = 0.21, P = 0.012), and inferior BMO-MRW (R2 = 0.27, P = 0.002). No significant correlations were found for LC area and anterior LC depth (P ≥ 0.452). Conclusions Evaluating the distribution pattern and structure-function correlations of different laminar and prelaminar EDI OCT-derived parameters in glaucomatous patients, we found better results for neural tissue-based indexes (compared to LC-derived parameters). The diagnostic utility of each parameter deserves further investigations. |
| first_indexed | 2024-12-13T01:24:41Z |
| format | Article |
| id | doaj.art-7f078c6e667b4e629e95dec696493c35 |
| institution | Directory Open Access Journal |
| issn | 1471-2415 |
| language | English |
| last_indexed | 2024-12-13T01:24:41Z |
| publishDate | 2019-02-01 |
| publisher | BMC |
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| spelling | doaj.art-7f078c6e667b4e629e95dec696493c352022-12-22T00:04:08ZengBMCBMC Ophthalmology1471-24152019-02-011911810.1186/s12886-019-1054-9Structure-function relationships in glaucoma using enhanced depth imaging optical coherence tomography-derived parameters: a cross-sectional observational studyFlavio S. Lopes0Igor Matsubara1Izabela Almeida2Syril K. Dorairaj3Roberto M. Vessani4Augusto Paranhos Jr5Tiago S. Prata6Glaucoma Service, Department of Ophthalmology, Federal University of São PauloGlaucoma Service, Department of Ophthalmology, Federal University of São PauloGlaucoma Service, Department of Ophthalmology, Federal University of São PauloDepartment of Ophthalmology, Mayo ClinicGlaucoma Service, Department of Ophthalmology, Federal University of São PauloGlaucoma Service, Department of Ophthalmology, Federal University of São PauloGlaucoma Service, Department of Ophthalmology, Federal University of São PauloAbstract Background To investigate structural and functional correlations in glaucoma patients using enhanced depth imaging spectral-domain optical coherence tomography (EDI OCT)-derived parameters. Methods We prospectively enrolled healthy participants and glaucomatous patients with a wide range of disease stages. All participants underwent visual field (VF) testing (SITA - Standard 24–2; Carl Zeiss Meditec, Dublin, CA) and EDI OCT imaging (Spectralis; Heidelberg Engineering Co., Heidelberg, Germany). The following optic nerve head parameters were measured on serial vertical EDI OCT B-scans by two experienced examiners masked to patients clinical data: lamina cribrosa (LC) thickness and area, prelaminar neural tissue thickness and area, anterior LC depth, Bruch’s membrane opening (BMO) and average, superior, and inferior BMO-minimum rim width (BMO-MRW). Only good quality images were considered, and whenever both eyes were eligible, one was randomly selected for analysis. Scatter plots were constructed to investigate correlations between each anatomic parameter and patient’s VF status (based on VF index [VFI] values). Results A total of 73 eyes of 73 patients were included. All EDI OCT parameters evaluated differed significantly between glaucomatous and control eyes (P ≤ 0.045). A secondary analysis, in which glaucomatous patients were divided according to VF mean deviation index values into 3 groups (mild [G1; > − 6 dB], moderate [G2; − 6 to − 12 dB] and advanced [G3; <− 12 dB] glaucoma), revealed that average BMO-MRW was the EDI OCT parameter that presented more significant differences between the different stages of glaucoma. Significant structure-function correlations were found between VFI values and prelaminar neural tissue area (R2 = 0.20, P = 0.017), average BMO-MRW (R2 = 0.35, P ≤ 0.001), superior BMO-MRW (R2 = 0.21, P = 0.012), and inferior BMO-MRW (R2 = 0.27, P = 0.002). No significant correlations were found for LC area and anterior LC depth (P ≥ 0.452). Conclusions Evaluating the distribution pattern and structure-function correlations of different laminar and prelaminar EDI OCT-derived parameters in glaucomatous patients, we found better results for neural tissue-based indexes (compared to LC-derived parameters). The diagnostic utility of each parameter deserves further investigations.http://link.springer.com/article/10.1186/s12886-019-1054-9GlaucomaTomography, opticalOptic nerve diseases |
| spellingShingle | Flavio S. Lopes Igor Matsubara Izabela Almeida Syril K. Dorairaj Roberto M. Vessani Augusto Paranhos Jr Tiago S. Prata Structure-function relationships in glaucoma using enhanced depth imaging optical coherence tomography-derived parameters: a cross-sectional observational study BMC Ophthalmology Glaucoma Tomography, optical Optic nerve diseases |
| title | Structure-function relationships in glaucoma using enhanced depth imaging optical coherence tomography-derived parameters: a cross-sectional observational study |
| title_full | Structure-function relationships in glaucoma using enhanced depth imaging optical coherence tomography-derived parameters: a cross-sectional observational study |
| title_fullStr | Structure-function relationships in glaucoma using enhanced depth imaging optical coherence tomography-derived parameters: a cross-sectional observational study |
| title_full_unstemmed | Structure-function relationships in glaucoma using enhanced depth imaging optical coherence tomography-derived parameters: a cross-sectional observational study |
| title_short | Structure-function relationships in glaucoma using enhanced depth imaging optical coherence tomography-derived parameters: a cross-sectional observational study |
| title_sort | structure function relationships in glaucoma using enhanced depth imaging optical coherence tomography derived parameters a cross sectional observational study |
| topic | Glaucoma Tomography, optical Optic nerve diseases |
| url | http://link.springer.com/article/10.1186/s12886-019-1054-9 |
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