RANBP1, a member of the nuclear-cytoplasmic trafficking-regulator complex, is the terminal-striking point of the SGK1-dependent Th17+ pathological differentiation

RANBP1, a member of the nuclear-cytoplasmic trafficking-regulator complex, is the terminal-striking point of the SGK1-dependent Th17+ pathological differentiation

The Th17+ arrangement is critical for orchestrating both innate and acquired immune responses. In this context, the serum and glucocorticoid regulated kinase 1 (SGK1) exerts a key role in the governance of IL-23R-dependent Th17+ maturation, through the phosphorylation-dependent control of FOXO1 loca...

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Bibliographic Details
Main Authors: Carolina Brescia, Vincenzo Dattilo, Lucia D’Antona, Emanuela Chiarella, Rossana Tallerico, Salvatore Audia, Valentina Rocca, Rodolfo Iuliano, Francesco Trapasso, Nicola Perrotti, Rosario Amato
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Immunology
Subjects:
Th17+
nuclear transport
SGK1
RANBP1
FOXO1
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1213805/full

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