Development of an In Situ Photo-Crosslinking Antimicrobial Collagen Hydrogel for the Treatment of Infected Wounds
Antimicrobial hydrogels have received considerable attention in the treatment of bacteria-infected wounds. Herein, we develop a neutral, soluble collagen via modification with maleic anhydride, serving as a hydrogel precursor. Maleic anhydride-modified collagen (ColME) could form a gel after exposur...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-12-01
|
| Series: | Polymers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4360/15/24/4701 |
| _version_ | 1797379571190857728 |
|---|---|
| author | Song-Yi Wu Wei-Bor Tsai |
| author_facet | Song-Yi Wu Wei-Bor Tsai |
| author_sort | Song-Yi Wu |
| collection | DOAJ |
| description | Antimicrobial hydrogels have received considerable attention in the treatment of bacteria-infected wounds. Herein, we develop a neutral, soluble collagen via modification with maleic anhydride, serving as a hydrogel precursor. Maleic anhydride-modified collagen (ColME) could form a gel after exposure to UV light and be loaded with the antimicrobial agents, nisin and levofloxacin, to acquire antimicrobial ability. The ColME hydrogel containing nisin and levofloxacin had good cytocompatibility and effectively killed pathogenic bacterial strains, such as <i>Escherichia coli</i> and <i>Staphylococcus aureus</i>. The antimicrobial ColME hydrogels effectively supported the healing of a full-thickness skin wound infected with <i>S. aureus</i> in a mouse model. Our results demonstrate the potential of antimicrobial hydrogels as effective wound dressings via in situ photogelation for the healing of infected wounds. |
| first_indexed | 2024-03-08T20:25:07Z |
| format | Article |
| id | doaj.art-7f0bcb2369d94e59897b6b944ea8451a |
| institution | Directory Open Access Journal |
| issn | 2073-4360 |
| language | English |
| last_indexed | 2024-03-08T20:25:07Z |
| publishDate | 2023-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Polymers |
| spelling | doaj.art-7f0bcb2369d94e59897b6b944ea8451a2023-12-22T14:36:44ZengMDPI AGPolymers2073-43602023-12-011524470110.3390/polym15244701Development of an In Situ Photo-Crosslinking Antimicrobial Collagen Hydrogel for the Treatment of Infected WoundsSong-Yi Wu0Wei-Bor Tsai1Department of Chemical Engineering & Program of Green Materials and Precision Devices, National Taiwan University, No. 1, Sec. 4, Roosevelt Rd., Taipei 106, TaiwanDepartment of Chemical Engineering & Program of Green Materials and Precision Devices, National Taiwan University, No. 1, Sec. 4, Roosevelt Rd., Taipei 106, TaiwanAntimicrobial hydrogels have received considerable attention in the treatment of bacteria-infected wounds. Herein, we develop a neutral, soluble collagen via modification with maleic anhydride, serving as a hydrogel precursor. Maleic anhydride-modified collagen (ColME) could form a gel after exposure to UV light and be loaded with the antimicrobial agents, nisin and levofloxacin, to acquire antimicrobial ability. The ColME hydrogel containing nisin and levofloxacin had good cytocompatibility and effectively killed pathogenic bacterial strains, such as <i>Escherichia coli</i> and <i>Staphylococcus aureus</i>. The antimicrobial ColME hydrogels effectively supported the healing of a full-thickness skin wound infected with <i>S. aureus</i> in a mouse model. Our results demonstrate the potential of antimicrobial hydrogels as effective wound dressings via in situ photogelation for the healing of infected wounds.https://www.mdpi.com/2073-4360/15/24/4701antimicrobial peptideantibioticshydrogelinfected woundwound healing |
| spellingShingle | Song-Yi Wu Wei-Bor Tsai Development of an In Situ Photo-Crosslinking Antimicrobial Collagen Hydrogel for the Treatment of Infected Wounds Polymers antimicrobial peptide antibiotics hydrogel infected wound wound healing |
| title | Development of an In Situ Photo-Crosslinking Antimicrobial Collagen Hydrogel for the Treatment of Infected Wounds |
| title_full | Development of an In Situ Photo-Crosslinking Antimicrobial Collagen Hydrogel for the Treatment of Infected Wounds |
| title_fullStr | Development of an In Situ Photo-Crosslinking Antimicrobial Collagen Hydrogel for the Treatment of Infected Wounds |
| title_full_unstemmed | Development of an In Situ Photo-Crosslinking Antimicrobial Collagen Hydrogel for the Treatment of Infected Wounds |
| title_short | Development of an In Situ Photo-Crosslinking Antimicrobial Collagen Hydrogel for the Treatment of Infected Wounds |
| title_sort | development of an in situ photo crosslinking antimicrobial collagen hydrogel for the treatment of infected wounds |
| topic | antimicrobial peptide antibiotics hydrogel infected wound wound healing |
| url | https://www.mdpi.com/2073-4360/15/24/4701 |
| work_keys_str_mv | AT songyiwu developmentofaninsituphotocrosslinkingantimicrobialcollagenhydrogelforthetreatmentofinfectedwounds AT weibortsai developmentofaninsituphotocrosslinkingantimicrobialcollagenhydrogelforthetreatmentofinfectedwounds |