The Resistance to Host Antimicrobial Peptides in Infections Caused by Daptomycin-Resistant <i>Staphylococcus aureus</i>
Daptomycin is an important antibiotic for the treatment of infections caused by <i>Staphylococcus aureus</i>. The emergence of daptomycin resistance in <i>S. aureus</i> is associated with treatment failure and persistent infections with poor clinical outcomes. Here, we invest...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-01-01
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| Series: | Antibiotics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-6382/10/2/96 |
| Summary: | Daptomycin is an important antibiotic for the treatment of infections caused by <i>Staphylococcus aureus</i>. The emergence of daptomycin resistance in <i>S. aureus</i> is associated with treatment failure and persistent infections with poor clinical outcomes. Here, we investigated host innate immune responses against clinically derived, daptomycin-resistant (DAP-R) and -susceptible <i>S. aureus</i> paired isolates using a zebrafish infection model. We showed that the control of DAP-R <i>S. aureus</i> infections was attenuated in vivo due to cross-resistance to host cationic antimicrobial peptides. These data provide mechanistic understanding into persistent infections caused by DAP-R <i>S. aureus</i> and provide crucial insights into the adaptive evolution of this troublesome pathogen. |
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| ISSN: | 2079-6382 |