Vitamin D supplementation in the treatment of polycystic ovary syndrome: A meta-analysis of randomized controlled trials
Background: Vitamin D level is closely associated with the development of polycystic ovary syndrome (PCOS). We aimed to systematically evaluate the effects of vitamin D supplementation on patients with PCOS, to provide reliable evidence to the clinical treatment of PCOS. Methods: We searched PubMed,...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-03-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844023014986 |
| _version_ | 1797851858224545792 |
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| author | Biyun Zhang Xiuhua Yao Xingming Zhong Yang Hu Jianying Xu |
| author_facet | Biyun Zhang Xiuhua Yao Xingming Zhong Yang Hu Jianying Xu |
| author_sort | Biyun Zhang |
| collection | DOAJ |
| description | Background: Vitamin D level is closely associated with the development of polycystic ovary syndrome (PCOS). We aimed to systematically evaluate the effects of vitamin D supplementation on patients with PCOS, to provide reliable evidence to the clinical treatment of PCOS. Methods: We searched PubMed, Medline, EMbase, Cochrane Library, Web of Science, WanFang, China national knowledge infrastructure(CNKI) and Weipu databases for randomized controlled trials (RCTs) on vitamin D supplementation for the treatment of PCOS. Two reviewers independently screened literature, extracted data and evaluated the risk of bias of included RCTs. RevMan 5.3 software was used for meta-analysis. Results: 13 RCTs with 840 PCOS patients were included finally. Meta-analyses indicated that vitamin D supplementation increase the serum vitamin D level[mean difference(MD) = 17.81, 95% confidence interval(CI) (10.65, 24.97)] and endometrial thickness [MD = 1.78, 95%CI (0.49, 3.06), P = 0.007], reduce the serum hs-CRP [MD = −0.54, 95%CI (−1.00, −0.08)], parathyroid hormone[MD = −14.76, 95%CI (−28.32, −1.19)], total cholesterol[MD = −12.00, 95%CI (−18.36, −5.56)] and total testosterone level [MD = −0.17, 95%CI (−0.29, −0.05)] (all p < 0.05). No significant differences in the SHBG level [MD = 1.33, 95%CI (−2.70, 5.36)] and mF-G score [MD = 0.04, 95%CI (−0.79, 0.86)] between vitamin D and control group were found (all p > 0.05). Egger's tests showed that there were no publication biases in every synthesized result (all P > 0.05). Conclusion: Vitamin D may be helpful to improve the endocrine and metabolism-related indexes in patients with PCOS. More high-quality studies with larger sample size are warranted to further evaluate the role of vitamin D supplementation in patients with PCOS. |
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| format | Article |
| id | doaj.art-7f0daf01e0aa47909ed51f4a2cc5c0fe |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-04-09T19:23:29Z |
| publishDate | 2023-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-7f0daf01e0aa47909ed51f4a2cc5c0fe2023-04-05T08:22:45ZengElsevierHeliyon2405-84402023-03-0193e14291Vitamin D supplementation in the treatment of polycystic ovary syndrome: A meta-analysis of randomized controlled trialsBiyun Zhang0Xiuhua Yao1Xingming Zhong2Yang Hu3Jianying Xu4Reproductive Immunization Center,Guangdong Provincial Reproductive Science Institute(Guangdong Provincial Fertility Hospital), NHC Key Laboratory of Male Reproduction and Genetics, Guangzhou, Guangdong 510660, ChinaGynecology Department, Affiliated Shenzhen Maternity & Child Healthcare Hospital, Southern Medical University, Shenzhen, Guangdong, 518000, China; Corresponding author.Reproductive Immunization Center, Guangdong Provincial Reproductive Science Institute(Guangdong Provincial Fertility Hospital), NHC Key Laboratory of Male Reproduction and Genetics, Guangzhou, Guangdong, 510660, ChinaNHC Key Laboratory of Male Reproduction and Genetics, Guangdong Provincial Reproductive Science Institute, Guangdong Provincial Fertility Hospital, Guangzhou, Guangdong, 510660, ChinaCenter of Reproductive Medicine, Zhuhai Center for Maternal and Child Health Care, Zhuhai, Guangdong, 519000, ChinaBackground: Vitamin D level is closely associated with the development of polycystic ovary syndrome (PCOS). We aimed to systematically evaluate the effects of vitamin D supplementation on patients with PCOS, to provide reliable evidence to the clinical treatment of PCOS. Methods: We searched PubMed, Medline, EMbase, Cochrane Library, Web of Science, WanFang, China national knowledge infrastructure(CNKI) and Weipu databases for randomized controlled trials (RCTs) on vitamin D supplementation for the treatment of PCOS. Two reviewers independently screened literature, extracted data and evaluated the risk of bias of included RCTs. RevMan 5.3 software was used for meta-analysis. Results: 13 RCTs with 840 PCOS patients were included finally. Meta-analyses indicated that vitamin D supplementation increase the serum vitamin D level[mean difference(MD) = 17.81, 95% confidence interval(CI) (10.65, 24.97)] and endometrial thickness [MD = 1.78, 95%CI (0.49, 3.06), P = 0.007], reduce the serum hs-CRP [MD = −0.54, 95%CI (−1.00, −0.08)], parathyroid hormone[MD = −14.76, 95%CI (−28.32, −1.19)], total cholesterol[MD = −12.00, 95%CI (−18.36, −5.56)] and total testosterone level [MD = −0.17, 95%CI (−0.29, −0.05)] (all p < 0.05). No significant differences in the SHBG level [MD = 1.33, 95%CI (−2.70, 5.36)] and mF-G score [MD = 0.04, 95%CI (−0.79, 0.86)] between vitamin D and control group were found (all p > 0.05). Egger's tests showed that there were no publication biases in every synthesized result (all P > 0.05). Conclusion: Vitamin D may be helpful to improve the endocrine and metabolism-related indexes in patients with PCOS. More high-quality studies with larger sample size are warranted to further evaluate the role of vitamin D supplementation in patients with PCOS.http://www.sciencedirect.com/science/article/pii/S2405844023014986Polycystic ovary syndromeVitamin DTreatmentCareMeta-analysis |
| spellingShingle | Biyun Zhang Xiuhua Yao Xingming Zhong Yang Hu Jianying Xu Vitamin D supplementation in the treatment of polycystic ovary syndrome: A meta-analysis of randomized controlled trials Heliyon Polycystic ovary syndrome Vitamin D Treatment Care Meta-analysis |
| title | Vitamin D supplementation in the treatment of polycystic ovary syndrome: A meta-analysis of randomized controlled trials |
| title_full | Vitamin D supplementation in the treatment of polycystic ovary syndrome: A meta-analysis of randomized controlled trials |
| title_fullStr | Vitamin D supplementation in the treatment of polycystic ovary syndrome: A meta-analysis of randomized controlled trials |
| title_full_unstemmed | Vitamin D supplementation in the treatment of polycystic ovary syndrome: A meta-analysis of randomized controlled trials |
| title_short | Vitamin D supplementation in the treatment of polycystic ovary syndrome: A meta-analysis of randomized controlled trials |
| title_sort | vitamin d supplementation in the treatment of polycystic ovary syndrome a meta analysis of randomized controlled trials |
| topic | Polycystic ovary syndrome Vitamin D Treatment Care Meta-analysis |
| url | http://www.sciencedirect.com/science/article/pii/S2405844023014986 |
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