Optical coherence tomography biomarkers after intravitreal triamcinolone acetonide in patients with diabetic macular edema
Background and Objective: Optical coherence tomography (OCT) plays a crucial role in guiding the treatment and establishing the prognosis of diabetic macular edema (DME). We aimed to determine which OCT biomarkers respond better to intravitreal triamcinolone acetonide (IVTA) switch after antivascula...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2023-01-01
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| Series: | The Pan-American Journal of Ophthalmology |
| Subjects: | |
| Online Access: | http://www.thepajo.org/article.asp?issn=2666-4909;year=2023;volume=5;issue=1;spage=10;epage=10;aulast=Matias |
| _version_ | 1827292405092581376 |
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| author | Maria João Matias Vítor Miranda Catarina Pestana Aguiar Lilianne Duarte |
| author_facet | Maria João Matias Vítor Miranda Catarina Pestana Aguiar Lilianne Duarte |
| author_sort | Maria João Matias |
| collection | DOAJ |
| description | Background and Objective: Optical coherence tomography (OCT) plays a crucial role in guiding the treatment and establishing the prognosis of diabetic macular edema (DME). We aimed to determine which OCT biomarkers respond better to intravitreal triamcinolone acetonide (IVTA) switch after antivascular endothelial growth factor (anti-VEGF) treatment poor response.
Materials and Methods: Fifty-eight eyes with DME, submitted to IVTA switch, were included in this retrospective study. OCT biomarkers and best-corrected visual acuity (VA) were assessed, before and after treatment with a mean follow-up of 2.9 months.
Results: IVTA switch resulted in improved VA, central foveal thickness (CFT), and macular volume. Intraretinal cysts decreased or disappeared completely (P = 0.007) in 84.2% of the eyes, as well as the hyperreflective foci (P = 0.004) and the subretinal fluid (P = 0.02).
Conclusion: We show that IVTA switch is an effective rescue therapy in anti-VEGF therapy refractory DME. OCT plays an important role in selecting the most appropriate treatment, namely between anti-VEGF and steroids. |
| first_indexed | 2024-04-24T13:05:16Z |
| format | Article |
| id | doaj.art-7f11274e2b46452cbf6a745a54cf3580 |
| institution | Directory Open Access Journal |
| issn | 2666-4909 |
| language | English |
| last_indexed | 2024-04-24T13:05:16Z |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | The Pan-American Journal of Ophthalmology |
| spelling | doaj.art-7f11274e2b46452cbf6a745a54cf35802024-04-05T08:37:13ZengWolters Kluwer Medknow PublicationsThe Pan-American Journal of Ophthalmology2666-49092023-01-0151101010.4103/pajo.pajo_3_23Optical coherence tomography biomarkers after intravitreal triamcinolone acetonide in patients with diabetic macular edemaMaria João MatiasVítor MirandaCatarina Pestana AguiarLilianne DuarteBackground and Objective: Optical coherence tomography (OCT) plays a crucial role in guiding the treatment and establishing the prognosis of diabetic macular edema (DME). We aimed to determine which OCT biomarkers respond better to intravitreal triamcinolone acetonide (IVTA) switch after antivascular endothelial growth factor (anti-VEGF) treatment poor response. Materials and Methods: Fifty-eight eyes with DME, submitted to IVTA switch, were included in this retrospective study. OCT biomarkers and best-corrected visual acuity (VA) were assessed, before and after treatment with a mean follow-up of 2.9 months. Results: IVTA switch resulted in improved VA, central foveal thickness (CFT), and macular volume. Intraretinal cysts decreased or disappeared completely (P = 0.007) in 84.2% of the eyes, as well as the hyperreflective foci (P = 0.004) and the subretinal fluid (P = 0.02). Conclusion: We show that IVTA switch is an effective rescue therapy in anti-VEGF therapy refractory DME. OCT plays an important role in selecting the most appropriate treatment, namely between anti-VEGF and steroids.http://www.thepajo.org/article.asp?issn=2666-4909;year=2023;volume=5;issue=1;spage=10;epage=10;aulast=Matiasdiabetic macular edemaintravitreal triamcinolone acetonideoptical coherence tomography biomarkers |
| spellingShingle | Maria João Matias Vítor Miranda Catarina Pestana Aguiar Lilianne Duarte Optical coherence tomography biomarkers after intravitreal triamcinolone acetonide in patients with diabetic macular edema The Pan-American Journal of Ophthalmology diabetic macular edema intravitreal triamcinolone acetonide optical coherence tomography biomarkers |
| title | Optical coherence tomography biomarkers after intravitreal triamcinolone acetonide in patients with diabetic macular edema |
| title_full | Optical coherence tomography biomarkers after intravitreal triamcinolone acetonide in patients with diabetic macular edema |
| title_fullStr | Optical coherence tomography biomarkers after intravitreal triamcinolone acetonide in patients with diabetic macular edema |
| title_full_unstemmed | Optical coherence tomography biomarkers after intravitreal triamcinolone acetonide in patients with diabetic macular edema |
| title_short | Optical coherence tomography biomarkers after intravitreal triamcinolone acetonide in patients with diabetic macular edema |
| title_sort | optical coherence tomography biomarkers after intravitreal triamcinolone acetonide in patients with diabetic macular edema |
| topic | diabetic macular edema intravitreal triamcinolone acetonide optical coherence tomography biomarkers |
| url | http://www.thepajo.org/article.asp?issn=2666-4909;year=2023;volume=5;issue=1;spage=10;epage=10;aulast=Matias |
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