Vitamin D Boosts Alendronate Tail Effect on Bone Mineral Density in Postmenopausal Women with Osteoporosis
Vitamin D modulates bisphosphonate (BP) efficacy, but its contribution to bone mineral density (BMD) after BP discontinuation is not known. To address this topic, we performed a retrospective analysis of postmenopausal women exposed to alendronate (ALN) to treat osteoporosis who regularly continued...
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MDPI AG
2021-05-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/13/6/1878 |
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| author | Antonino Catalano Federica Bellone Domenico Santoro Peter Schwarz Agostino Gaudio Giorgio Basile Maria Carmela Sottile Sabrina Atena Stoian Francesco Corica Nunziata Morabito |
| author_facet | Antonino Catalano Federica Bellone Domenico Santoro Peter Schwarz Agostino Gaudio Giorgio Basile Maria Carmela Sottile Sabrina Atena Stoian Francesco Corica Nunziata Morabito |
| author_sort | Antonino Catalano |
| collection | DOAJ |
| description | Vitamin D modulates bisphosphonate (BP) efficacy, but its contribution to bone mineral density (BMD) after BP discontinuation is not known. To address this topic, we performed a retrospective analysis of postmenopausal women exposed to alendronate (ALN) to treat osteoporosis who regularly continued the supplementation of cholecalciferol or calcifediol at recommended doses. In the ninety-six recruited women (age 61.1 ± 6.9 years), ALN was administered for 31.2 ± 20.6 months and then discontinued for 33.3 ± 18.9 months. The modification of 25(OH)D serum levels over time was associated with a change of alkaline phosphatase (r = −0.22, <i>p</i> = 0.018) and C-terminal collagen type 1 telopeptide (r = −0.3, <i>p</i> = 0.06). Women in the tertile of the highest increase in 25(OH)D level showed a 5.7% BMD gain at lumbar spine, that was twice as great in comparison with participants with a lower 25(OH)D variation. At a multiple regression analysis, BMD change was associated with time since menopause (ß = 2.28, SE 0.44, <i>p</i> < 0.0001), FRAX score for major fracture (ß = −0.65, SE 0.29, <i>p</i> = 0.03), drug holiday duration (ß = −2.17, SE 0.27, <i>p</i> < 0.0001) and change of 25(OH)D levels (ß = 0.15, SE 0.03, <i>p</i> = 0.0007). After ALN discontinuation, improving the vitamin D status boosts the ALN tail effect on BMD. |
| first_indexed | 2024-03-10T10:51:45Z |
| format | Article |
| id | doaj.art-7f12c588da284b9282fae674956d5e83 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T10:51:45Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-7f12c588da284b9282fae674956d5e832023-11-21T22:10:10ZengMDPI AGNutrients2072-66432021-05-01136187810.3390/nu13061878Vitamin D Boosts Alendronate Tail Effect on Bone Mineral Density in Postmenopausal Women with OsteoporosisAntonino Catalano0Federica Bellone1Domenico Santoro2Peter Schwarz3Agostino Gaudio4Giorgio Basile5Maria Carmela Sottile6Sabrina Atena Stoian7Francesco Corica8Nunziata Morabito9Unit and School of Geriatrics, Department of Clinical and Experimental Medicine, University of Messina, Policlinico “G. Martino”, Via C. Valeria, 98125 Messina, ItalyUnit and School of Geriatrics, Department of Clinical and Experimental Medicine, University of Messina, Policlinico “G. Martino”, Via C. Valeria, 98125 Messina, ItalyUnit and School of Nephrology, Department of Clinical and Experimental Medicine, University of Messina, Policlinico “G. Martino”, Via C. Valeria, 98125 Messina, ItalyDepartment of Endocrinology and Diabetes and Bone-Metabolic Research Unit, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, 2100 Copenhagen, DenmarkUnit and School of Internal Medicine, Department of Clinical and Experimental Medicine, University of Catania, Policlinico “G. Rodolico”, Via S. Sofia 78, 95123 Catania, ItalyUnit and School of Geriatrics, Department of Clinical and Experimental Medicine, University of Messina, Policlinico “G. Martino”, Via C. Valeria, 98125 Messina, ItalyUnit and School of Geriatrics, Department of Clinical and Experimental Medicine, University of Messina, Policlinico “G. Martino”, Via C. Valeria, 98125 Messina, ItalyUnit and School of Geriatrics, Department of Clinical and Experimental Medicine, University of Messina, Policlinico “G. Martino”, Via C. Valeria, 98125 Messina, ItalyUnit and School of Geriatrics, Department of Clinical and Experimental Medicine, University of Messina, Policlinico “G. Martino”, Via C. Valeria, 98125 Messina, ItalyUnit and School of Geriatrics, Department of Clinical and Experimental Medicine, University of Messina, Policlinico “G. Martino”, Via C. Valeria, 98125 Messina, ItalyVitamin D modulates bisphosphonate (BP) efficacy, but its contribution to bone mineral density (BMD) after BP discontinuation is not known. To address this topic, we performed a retrospective analysis of postmenopausal women exposed to alendronate (ALN) to treat osteoporosis who regularly continued the supplementation of cholecalciferol or calcifediol at recommended doses. In the ninety-six recruited women (age 61.1 ± 6.9 years), ALN was administered for 31.2 ± 20.6 months and then discontinued for 33.3 ± 18.9 months. The modification of 25(OH)D serum levels over time was associated with a change of alkaline phosphatase (r = −0.22, <i>p</i> = 0.018) and C-terminal collagen type 1 telopeptide (r = −0.3, <i>p</i> = 0.06). Women in the tertile of the highest increase in 25(OH)D level showed a 5.7% BMD gain at lumbar spine, that was twice as great in comparison with participants with a lower 25(OH)D variation. At a multiple regression analysis, BMD change was associated with time since menopause (ß = 2.28, SE 0.44, <i>p</i> < 0.0001), FRAX score for major fracture (ß = −0.65, SE 0.29, <i>p</i> = 0.03), drug holiday duration (ß = −2.17, SE 0.27, <i>p</i> < 0.0001) and change of 25(OH)D levels (ß = 0.15, SE 0.03, <i>p</i> = 0.0007). After ALN discontinuation, improving the vitamin D status boosts the ALN tail effect on BMD.https://www.mdpi.com/2072-6643/13/6/1878bisphosphonatesalendronatevitamin Dosteoporosispostmenopausaldrug holiday |
| spellingShingle | Antonino Catalano Federica Bellone Domenico Santoro Peter Schwarz Agostino Gaudio Giorgio Basile Maria Carmela Sottile Sabrina Atena Stoian Francesco Corica Nunziata Morabito Vitamin D Boosts Alendronate Tail Effect on Bone Mineral Density in Postmenopausal Women with Osteoporosis Nutrients bisphosphonates alendronate vitamin D osteoporosis postmenopausal drug holiday |
| title | Vitamin D Boosts Alendronate Tail Effect on Bone Mineral Density in Postmenopausal Women with Osteoporosis |
| title_full | Vitamin D Boosts Alendronate Tail Effect on Bone Mineral Density in Postmenopausal Women with Osteoporosis |
| title_fullStr | Vitamin D Boosts Alendronate Tail Effect on Bone Mineral Density in Postmenopausal Women with Osteoporosis |
| title_full_unstemmed | Vitamin D Boosts Alendronate Tail Effect on Bone Mineral Density in Postmenopausal Women with Osteoporosis |
| title_short | Vitamin D Boosts Alendronate Tail Effect on Bone Mineral Density in Postmenopausal Women with Osteoporosis |
| title_sort | vitamin d boosts alendronate tail effect on bone mineral density in postmenopausal women with osteoporosis |
| topic | bisphosphonates alendronate vitamin D osteoporosis postmenopausal drug holiday |
| url | https://www.mdpi.com/2072-6643/13/6/1878 |
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