Functionally integrating nanoparticles alleviate deep vein thrombosis in pregnancy and rescue intrauterine growth restriction
There is still an unmet need for effective and safe drugs to treat deep vein thrombosis during pregnancy, a life-threatening condition for the mother and fetus. Here, the authors show that engineered multifunctional nanoparticles can site-specifically dissolve thrombi and reverse deep vein thrombosi...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-34878-2 |
| _version_ | 1828096968013905920 |
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| author | Juan Cheng Siqi Zhang Chenwen Li Ke Li Xiaoyan Jia Quanfang Wei Hongbo Qi Jianxiang Zhang |
| author_facet | Juan Cheng Siqi Zhang Chenwen Li Ke Li Xiaoyan Jia Quanfang Wei Hongbo Qi Jianxiang Zhang |
| author_sort | Juan Cheng |
| collection | DOAJ |
| description | There is still an unmet need for effective and safe drugs to treat deep vein thrombosis during pregnancy, a life-threatening condition for the mother and fetus. Here, the authors show that engineered multifunctional nanoparticles can site-specifically dissolve thrombi and reverse deep vein thrombosis-mediated intrauterine growth restriction and delayed development of fetuses in pregnant rats. |
| first_indexed | 2024-04-11T07:39:42Z |
| format | Article |
| id | doaj.art-7f12f5d79929417fbd56120f34de5138 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-11T07:39:42Z |
| publishDate | 2022-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-7f12f5d79929417fbd56120f34de51382022-12-22T04:36:38ZengNature PortfolioNature Communications2041-17232022-11-0113112110.1038/s41467-022-34878-2Functionally integrating nanoparticles alleviate deep vein thrombosis in pregnancy and rescue intrauterine growth restrictionJuan Cheng0Siqi Zhang1Chenwen Li2Ke Li3Xiaoyan Jia4Quanfang Wei5Hongbo Qi6Jianxiang Zhang7Chongqing Key Laboratory of Maternal and Fetal Medicine, The First Affiliated Hospital of Chongqing Medical UniversityChongqing Key Laboratory of Maternal and Fetal Medicine, The First Affiliated Hospital of Chongqing Medical UniversityDepartment of Pharmaceutics, College of Pharmacy, Third Military Medical University (Army Medical University)Chongqing Key Laboratory of Maternal and Fetal Medicine, The First Affiliated Hospital of Chongqing Medical UniversityChongqing Key Laboratory of Maternal and Fetal Medicine, The First Affiliated Hospital of Chongqing Medical UniversityBiomedical Analysis Center, College of Basic Medical Sciences, Third Military Medical University (Army Medical University)Chongqing Key Laboratory of Maternal and Fetal Medicine, The First Affiliated Hospital of Chongqing Medical UniversityDepartment of Pharmaceutics, College of Pharmacy, Third Military Medical University (Army Medical University)There is still an unmet need for effective and safe drugs to treat deep vein thrombosis during pregnancy, a life-threatening condition for the mother and fetus. Here, the authors show that engineered multifunctional nanoparticles can site-specifically dissolve thrombi and reverse deep vein thrombosis-mediated intrauterine growth restriction and delayed development of fetuses in pregnant rats.https://doi.org/10.1038/s41467-022-34878-2 |
| spellingShingle | Juan Cheng Siqi Zhang Chenwen Li Ke Li Xiaoyan Jia Quanfang Wei Hongbo Qi Jianxiang Zhang Functionally integrating nanoparticles alleviate deep vein thrombosis in pregnancy and rescue intrauterine growth restriction Nature Communications |
| title | Functionally integrating nanoparticles alleviate deep vein thrombosis in pregnancy and rescue intrauterine growth restriction |
| title_full | Functionally integrating nanoparticles alleviate deep vein thrombosis in pregnancy and rescue intrauterine growth restriction |
| title_fullStr | Functionally integrating nanoparticles alleviate deep vein thrombosis in pregnancy and rescue intrauterine growth restriction |
| title_full_unstemmed | Functionally integrating nanoparticles alleviate deep vein thrombosis in pregnancy and rescue intrauterine growth restriction |
| title_short | Functionally integrating nanoparticles alleviate deep vein thrombosis in pregnancy and rescue intrauterine growth restriction |
| title_sort | functionally integrating nanoparticles alleviate deep vein thrombosis in pregnancy and rescue intrauterine growth restriction |
| url | https://doi.org/10.1038/s41467-022-34878-2 |
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