Fish Models for Exploring Mitochondrial Dysfunction Affecting Neurodegenerative Disorders
Neurodegenerative disorders are characterized by the progressive loss of neuronal structure or function, resulting in memory loss and movement disorders. Although the detailed pathogenic mechanism has not been elucidated, it is thought to be related to the loss of mitochondrial function in the proce...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-04-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/24/8/7079 |
| _version_ | 1797605163684331520 |
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| author | Takayoshi Otsuka Hideaki Matsui |
| author_facet | Takayoshi Otsuka Hideaki Matsui |
| author_sort | Takayoshi Otsuka |
| collection | DOAJ |
| description | Neurodegenerative disorders are characterized by the progressive loss of neuronal structure or function, resulting in memory loss and movement disorders. Although the detailed pathogenic mechanism has not been elucidated, it is thought to be related to the loss of mitochondrial function in the process of aging. Animal models that mimic the pathology of a disease are essential for understanding human diseases. In recent years, small fish have become ideal vertebrate models for human disease due to their high genetic and histological homology to humans, ease of in vivo imaging, and ease of genetic manipulation. In this review, we first outline the impact of mitochondrial dysfunction on the progression of neurodegenerative diseases. Then, we highlight the advantages of small fish as model organisms, and present examples of previous studies regarding mitochondria-related neuronal disorders. Lastly, we discuss the applicability of the turquoise killifish, a unique model for aging research, as a model for neurodegenerative diseases. Small fish models are expected to advance our understanding of the mitochondrial function in vivo, the pathogenesis of neurodegenerative diseases, and be important tools for developing therapies to treat diseases. |
| first_indexed | 2024-03-11T04:57:14Z |
| format | Article |
| id | doaj.art-7f12fa1751234f349186a1b1f4f6c27a |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T04:57:14Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-7f12fa1751234f349186a1b1f4f6c27a2023-11-17T19:34:50ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-04-01248707910.3390/ijms24087079Fish Models for Exploring Mitochondrial Dysfunction Affecting Neurodegenerative DisordersTakayoshi Otsuka0Hideaki Matsui1Department of Neuroscience of Disease, Brain Research Institute, Niigata University, Niigata 951-8585, JapanDepartment of Neuroscience of Disease, Brain Research Institute, Niigata University, Niigata 951-8585, JapanNeurodegenerative disorders are characterized by the progressive loss of neuronal structure or function, resulting in memory loss and movement disorders. Although the detailed pathogenic mechanism has not been elucidated, it is thought to be related to the loss of mitochondrial function in the process of aging. Animal models that mimic the pathology of a disease are essential for understanding human diseases. In recent years, small fish have become ideal vertebrate models for human disease due to their high genetic and histological homology to humans, ease of in vivo imaging, and ease of genetic manipulation. In this review, we first outline the impact of mitochondrial dysfunction on the progression of neurodegenerative diseases. Then, we highlight the advantages of small fish as model organisms, and present examples of previous studies regarding mitochondria-related neuronal disorders. Lastly, we discuss the applicability of the turquoise killifish, a unique model for aging research, as a model for neurodegenerative diseases. Small fish models are expected to advance our understanding of the mitochondrial function in vivo, the pathogenesis of neurodegenerative diseases, and be important tools for developing therapies to treat diseases.https://www.mdpi.com/1422-0067/24/8/7079mitochondrianeurodegenerative disorderszebrafishmedakaturquoise killifish |
| spellingShingle | Takayoshi Otsuka Hideaki Matsui Fish Models for Exploring Mitochondrial Dysfunction Affecting Neurodegenerative Disorders International Journal of Molecular Sciences mitochondria neurodegenerative disorders zebrafish medaka turquoise killifish |
| title | Fish Models for Exploring Mitochondrial Dysfunction Affecting Neurodegenerative Disorders |
| title_full | Fish Models for Exploring Mitochondrial Dysfunction Affecting Neurodegenerative Disorders |
| title_fullStr | Fish Models for Exploring Mitochondrial Dysfunction Affecting Neurodegenerative Disorders |
| title_full_unstemmed | Fish Models for Exploring Mitochondrial Dysfunction Affecting Neurodegenerative Disorders |
| title_short | Fish Models for Exploring Mitochondrial Dysfunction Affecting Neurodegenerative Disorders |
| title_sort | fish models for exploring mitochondrial dysfunction affecting neurodegenerative disorders |
| topic | mitochondria neurodegenerative disorders zebrafish medaka turquoise killifish |
| url | https://www.mdpi.com/1422-0067/24/8/7079 |
| work_keys_str_mv | AT takayoshiotsuka fishmodelsforexploringmitochondrialdysfunctionaffectingneurodegenerativedisorders AT hideakimatsui fishmodelsforexploringmitochondrialdysfunctionaffectingneurodegenerativedisorders |