Modeling of mitochondrial genetic polymorphisms reveals induction of heteroplasmy by pleiotropic disease locus 10398A>G

Modeling of mitochondrial genetic polymorphisms reveals induction of heteroplasmy by pleiotropic disease locus 10398A>G

Abstract Mitochondrial (MT) dysfunction has been associated with several neurodegenerative diseases including Alzheimer’s disease (AD). While MT-copy number differences have been implicated in AD, the effect of MT heteroplasmy on AD has not been well characterized. Here, we analyzed over 1800 whole...

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Bibliographic Details
Main Authors: Molly Smullen, Meagan N. Olson, Liam F. Murray, Madhusoodhanan Suresh, Guang Yan, Pepper Dawes, Nathaniel J. Barton, Jivanna N. Mason, Yucheng Zhang, Aria A. Fernandez-Fontaine, George M. Church, Diego Mastroeni, Qi Wang, Elaine T. Lim, Yingleong Chan, Benjamin Readhead
Format: Article
Language:English
Published: Nature Portfolio 2023-06-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-37541-y

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