A systematic review of brain imaging findings in neurological infection with Japanese encephalitis virus compared with Dengue virus
Objectives: Japanese encephalitis virus (JEV) and dengue virus (DENV) represent important causes of encephalitis in Asia. Brain imaging may provide diagnostic clues about the etiology of infectious encephalitis. We performed a systematic review of brain imaging findings in Japanese encephalitis (JE)...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2022-06-01
|
| Series: | International Journal of Infectious Diseases |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1201971222001485 |
| _version_ | 1828823950960885760 |
|---|---|
| author | Thomas Pichl Catherine J Wedderburn Chandrashekar Hoskote Lance Turtle Tehmina Bharucha |
| author_facet | Thomas Pichl Catherine J Wedderburn Chandrashekar Hoskote Lance Turtle Tehmina Bharucha |
| author_sort | Thomas Pichl |
| collection | DOAJ |
| description | Objectives: Japanese encephalitis virus (JEV) and dengue virus (DENV) represent important causes of encephalitis in Asia. Brain imaging may provide diagnostic clues about the etiology of infectious encephalitis. We performed a systematic review of brain imaging findings in Japanese encephalitis (JE) and DENV neurological infection (dengue) to identify characteristic lesions. Methodology: Five databases were searched. We included all study types and imaging techniques. Laboratory methods were categorized using diagnostic confidence levels. Imaging data were synthesized, and focal findings are presented as proportions for JE and dengue and for subgroups based on diagnostic confidence. Principal findings: Thalamic lesions were the most reported magnetic resonance imaging finding in both diseases but appeared to occur more often in JE (74% in 23 studies) than dengue (29.4% in 58 studies). In cases diagnosed with antigen or nucleic acid tests, thalamic lesions were reported frequently in both JE (76.5% in 17 studies) and dengue (65.2% in 23 studies). Significance: The results suggest that thalamic lesions frequently occur in both JE and dengue encephalitis. No radiological findings were found to be pathognomonic of either disease. Although brain imaging may support a diagnosis, laboratory confirmation with highly specific tests remains crucial. |
| first_indexed | 2024-12-12T13:46:46Z |
| format | Article |
| id | doaj.art-7f14c62907934955806ead80b03bd68b |
| institution | Directory Open Access Journal |
| issn | 1201-9712 |
| language | English |
| last_indexed | 2024-12-12T13:46:46Z |
| publishDate | 2022-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Infectious Diseases |
| spelling | doaj.art-7f14c62907934955806ead80b03bd68b2022-12-22T00:22:40ZengElsevierInternational Journal of Infectious Diseases1201-97122022-06-01119102110A systematic review of brain imaging findings in neurological infection with Japanese encephalitis virus compared with Dengue virusThomas Pichl0Catherine J Wedderburn1Chandrashekar Hoskote2Lance Turtle3Tehmina Bharucha4London School of Hygiene and Tropical Medicine, Keppel St, London, WC1E 7HT, United Kingdom; Aberdeen University, King's College, Aberdeen, AB24 3FX, United Kingdom; Corresponding author.London School of Hygiene and Tropical Medicine, Keppel St, London, WC1E 7HT, United Kingdom; Neuroscience Institute and the Department of Paediatrics and Child Health, University of Cape Town, Cape Town, South AfricaLysholm Department of Neuroradiology, National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation Trust, Queen Square, London, UKNIHR Health Protection Research Unit for Emerging and Zoonotic Infections, Institute of Infection, Veterinary and Ecological Sciences University of Liverpool, 8 West Derby Street, Liverpool, L69 7BE, UK; Tropical & Infectious Disease Unit, Liverpool University Hospitals NHS Foundation Trust (Member of Liverpool Health Partners), Liverpool, L7 8XP, UKDepartment of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, United Kingdom; Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit, Microbiology Laboratory, Mahosot Hospital, Vientiane, Lao PDRObjectives: Japanese encephalitis virus (JEV) and dengue virus (DENV) represent important causes of encephalitis in Asia. Brain imaging may provide diagnostic clues about the etiology of infectious encephalitis. We performed a systematic review of brain imaging findings in Japanese encephalitis (JE) and DENV neurological infection (dengue) to identify characteristic lesions. Methodology: Five databases were searched. We included all study types and imaging techniques. Laboratory methods were categorized using diagnostic confidence levels. Imaging data were synthesized, and focal findings are presented as proportions for JE and dengue and for subgroups based on diagnostic confidence. Principal findings: Thalamic lesions were the most reported magnetic resonance imaging finding in both diseases but appeared to occur more often in JE (74% in 23 studies) than dengue (29.4% in 58 studies). In cases diagnosed with antigen or nucleic acid tests, thalamic lesions were reported frequently in both JE (76.5% in 17 studies) and dengue (65.2% in 23 studies). Significance: The results suggest that thalamic lesions frequently occur in both JE and dengue encephalitis. No radiological findings were found to be pathognomonic of either disease. Although brain imaging may support a diagnosis, laboratory confirmation with highly specific tests remains crucial.http://www.sciencedirect.com/science/article/pii/S1201971222001485encephalitisdengueJapanese encephalitisneuroimagingmagnetic resonance imagingx-ray computed tomography |
| spellingShingle | Thomas Pichl Catherine J Wedderburn Chandrashekar Hoskote Lance Turtle Tehmina Bharucha A systematic review of brain imaging findings in neurological infection with Japanese encephalitis virus compared with Dengue virus International Journal of Infectious Diseases encephalitis dengue Japanese encephalitis neuroimaging magnetic resonance imaging x-ray computed tomography |
| title | A systematic review of brain imaging findings in neurological infection with Japanese encephalitis virus compared with Dengue virus |
| title_full | A systematic review of brain imaging findings in neurological infection with Japanese encephalitis virus compared with Dengue virus |
| title_fullStr | A systematic review of brain imaging findings in neurological infection with Japanese encephalitis virus compared with Dengue virus |
| title_full_unstemmed | A systematic review of brain imaging findings in neurological infection with Japanese encephalitis virus compared with Dengue virus |
| title_short | A systematic review of brain imaging findings in neurological infection with Japanese encephalitis virus compared with Dengue virus |
| title_sort | systematic review of brain imaging findings in neurological infection with japanese encephalitis virus compared with dengue virus |
| topic | encephalitis dengue Japanese encephalitis neuroimaging magnetic resonance imaging x-ray computed tomography |
| url | http://www.sciencedirect.com/science/article/pii/S1201971222001485 |
| work_keys_str_mv | AT thomaspichl asystematicreviewofbrainimagingfindingsinneurologicalinfectionwithjapaneseencephalitisviruscomparedwithdenguevirus AT catherinejwedderburn asystematicreviewofbrainimagingfindingsinneurologicalinfectionwithjapaneseencephalitisviruscomparedwithdenguevirus AT chandrashekarhoskote asystematicreviewofbrainimagingfindingsinneurologicalinfectionwithjapaneseencephalitisviruscomparedwithdenguevirus AT lanceturtle asystematicreviewofbrainimagingfindingsinneurologicalinfectionwithjapaneseencephalitisviruscomparedwithdenguevirus AT tehminabharucha asystematicreviewofbrainimagingfindingsinneurologicalinfectionwithjapaneseencephalitisviruscomparedwithdenguevirus AT thomaspichl systematicreviewofbrainimagingfindingsinneurologicalinfectionwithjapaneseencephalitisviruscomparedwithdenguevirus AT catherinejwedderburn systematicreviewofbrainimagingfindingsinneurologicalinfectionwithjapaneseencephalitisviruscomparedwithdenguevirus AT chandrashekarhoskote systematicreviewofbrainimagingfindingsinneurologicalinfectionwithjapaneseencephalitisviruscomparedwithdenguevirus AT lanceturtle systematicreviewofbrainimagingfindingsinneurologicalinfectionwithjapaneseencephalitisviruscomparedwithdenguevirus AT tehminabharucha systematicreviewofbrainimagingfindingsinneurologicalinfectionwithjapaneseencephalitisviruscomparedwithdenguevirus |