Outstanding Prevalence of Methicillin Resistant Staphylococcus aureus in Neonatal Omphalitis
Introduction: Omphalitis is the infection of the umbilical cord stump, which can lead to septicaemia and significant neonatal morbidity and mortality. Very little data is available on the aetiology of neonatal omphalitis in India. Aim: To identify the causative agents of omphalitis in neonates...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2016-09-01
|
| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/8590/22799_CE[Ra1]_F(GH)_PF1(ROESAK)_PFA(AK).pdf |
| _version_ | 1831593307655897088 |
|---|---|
| author | Mallika Sengupta Sayantan Banerjee Pritam Banerjee Partha Guchhait |
| author_facet | Mallika Sengupta Sayantan Banerjee Pritam Banerjee Partha Guchhait |
| author_sort | Mallika Sengupta |
| collection | DOAJ |
| description | Introduction: Omphalitis is the infection of the umbilical cord
stump, which can lead to septicaemia and significant neonatal
morbidity and mortality. Very little data is available on the
aetiology of neonatal omphalitis in India.
Aim: To identify the causative agents of omphalitis in neonates
and determine the antimicrobial susceptibility patterns of the
isolates.
Materials and Methods: A prospective study was conducted
at ESI-PGIMSR and ESIC Medical College, Joka, a tertiary
care teaching hospital in Eastern India for a period of four
months (from 1st January 2016 to 30th April 2016). Neonates
were screened for omphalitis on the basis of presence of pus
and redness for inclusion. Clinical examination, Gram stain
and culture of umbilical discharge, identification of organisms
by biochemical tests and VITEK 2 Compact (bioMereiux Inc.,
France) was done. Antimicrobial susceptibility by Kirby Bauer
disc diffusion method and E-strip agar diffusion method (for
vancomycin and teicoplanin) were performed and interpreted
according to the Clinical and Laboratory Standards Institute
(CLSI) guidelines version 2015.
Results: A total of 623 neonates were screened, among
whom 21 (3.37%) were positive for our screening criteria for
omphalitis. Cultures from the exudates of those cases yielded
growth of Staphylococcus aureus in 19 (90.47%) samples, all
of which were found to be methicillin resistant Staphylococcus
aureus (MRSA). Resistance to erythromycin was seen among
36.82% isolates and inducible clindamycin resistance was seen
among 31.57% isolates of Staphylococcus aureus.
Conclusion: MRSA can be the most common cause of
omphalitis. However, this finding needs to be evaluated in larger
prospective studies. |
| first_indexed | 2024-12-18T11:40:47Z |
| format | Article |
| id | doaj.art-7f152ff6b5714358afeac5512fb555be |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-12-18T11:40:47Z |
| publishDate | 2016-09-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-7f152ff6b5714358afeac5512fb555be2022-12-21T21:09:25ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2016-09-01109DM01DM0310.7860/JCDR/2016/22799.8590Outstanding Prevalence of Methicillin Resistant Staphylococcus aureus in Neonatal OmphalitisMallika Sengupta0Sayantan Banerjee1Pritam Banerjee2Partha Guchhait3Senior Resident, Department of Microbiology, ESI-PGIMSR, ESIC Medical College and ESIC Hospital, Joka, Kolkata, West Bengal, India.Assistant Professor, Department of Microbiology, ESI-PGIMSR, ESIC Medical College and ESIC Hospital, Joka, Kolkata, West Bengal, India.Assistant Professor, Department of Paediatrics, ESI-PGIMSR, ESIC Medical College and ESIC Hospital, Joka, Kolkata, West Bengal, India.Senior Resident, Department of Microbiology, ESI-PGIMSR, ESIC Medical College and ESIC Hospital, Joka, Kolkata, West Bengal, India.Introduction: Omphalitis is the infection of the umbilical cord stump, which can lead to septicaemia and significant neonatal morbidity and mortality. Very little data is available on the aetiology of neonatal omphalitis in India. Aim: To identify the causative agents of omphalitis in neonates and determine the antimicrobial susceptibility patterns of the isolates. Materials and Methods: A prospective study was conducted at ESI-PGIMSR and ESIC Medical College, Joka, a tertiary care teaching hospital in Eastern India for a period of four months (from 1st January 2016 to 30th April 2016). Neonates were screened for omphalitis on the basis of presence of pus and redness for inclusion. Clinical examination, Gram stain and culture of umbilical discharge, identification of organisms by biochemical tests and VITEK 2 Compact (bioMereiux Inc., France) was done. Antimicrobial susceptibility by Kirby Bauer disc diffusion method and E-strip agar diffusion method (for vancomycin and teicoplanin) were performed and interpreted according to the Clinical and Laboratory Standards Institute (CLSI) guidelines version 2015. Results: A total of 623 neonates were screened, among whom 21 (3.37%) were positive for our screening criteria for omphalitis. Cultures from the exudates of those cases yielded growth of Staphylococcus aureus in 19 (90.47%) samples, all of which were found to be methicillin resistant Staphylococcus aureus (MRSA). Resistance to erythromycin was seen among 36.82% isolates and inducible clindamycin resistance was seen among 31.57% isolates of Staphylococcus aureus. Conclusion: MRSA can be the most common cause of omphalitis. However, this finding needs to be evaluated in larger prospective studies.https://jcdr.net/articles/PDF/8590/22799_CE[Ra1]_F(GH)_PF1(ROESAK)_PFA(AK).pdfnewbornresistanceumbilical dischargeumbilicus |
| spellingShingle | Mallika Sengupta Sayantan Banerjee Pritam Banerjee Partha Guchhait Outstanding Prevalence of Methicillin Resistant Staphylococcus aureus in Neonatal Omphalitis Journal of Clinical and Diagnostic Research newborn resistance umbilical discharge umbilicus |
| title | Outstanding Prevalence of Methicillin Resistant Staphylococcus aureus in Neonatal Omphalitis |
| title_full | Outstanding Prevalence of Methicillin Resistant Staphylococcus aureus in Neonatal Omphalitis |
| title_fullStr | Outstanding Prevalence of Methicillin Resistant Staphylococcus aureus in Neonatal Omphalitis |
| title_full_unstemmed | Outstanding Prevalence of Methicillin Resistant Staphylococcus aureus in Neonatal Omphalitis |
| title_short | Outstanding Prevalence of Methicillin Resistant Staphylococcus aureus in Neonatal Omphalitis |
| title_sort | outstanding prevalence of methicillin resistant staphylococcus aureus in neonatal omphalitis |
| topic | newborn resistance umbilical discharge umbilicus |
| url | https://jcdr.net/articles/PDF/8590/22799_CE[Ra1]_F(GH)_PF1(ROESAK)_PFA(AK).pdf |
| work_keys_str_mv | AT mallikasengupta outstandingprevalenceofmethicillinresistantstaphylococcusaureusinneonatalomphalitis AT sayantanbanerjee outstandingprevalenceofmethicillinresistantstaphylococcusaureusinneonatalomphalitis AT pritambanerjee outstandingprevalenceofmethicillinresistantstaphylococcusaureusinneonatalomphalitis AT parthaguchhait outstandingprevalenceofmethicillinresistantstaphylococcusaureusinneonatalomphalitis |